Results 1 to 10 of about 10,379 (180)

Implications of canonical histone H3.1 and histone variant H3.3 in cancer [PDF]

Open Biology
Histones are the fundamental building blocks of chromatin and serve as pivotal regulators of gene expression. Differential expression and mutations of H3.1 and H3.3 genes have been implicated in the pathogenesis of various cancer types. Mutations in H3.3,
Peng Wu, Li Wang, Ting Wen, Qiao Yi Chen
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H3.1K27M-induced misregulation of the TONSOKU-H3.1 pathway causes genomic instability [PDF]

Nature Communications
The oncomutation lysine 27-to-methionine in histone H3 (H3K27M) is frequently identified in tumors of patients with diffuse midline glioma-H3K27 altered (DMG-H3K27a).
Wenxin Yuan, Yi-Chun Huang, Chantal LeBlanc, Axel Poulet, Francisca N. De Luna Vitorino, Devisree Valsakumar, Renee Dean, Benjamin A. Garcia, Josien C. van Wolfswinkel, Philipp Voigt, Yannick Jacob   +10 more
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H3.3 deposition counteracts the replication-dependent enrichment of H3.1 at chromocenters in embryonic stem cells [PDF]

Nature Communications
Chromocenters in mouse cells are membrane-less nuclear compartments representing typical heterochromatin stably maintained during cell cycle. We explore how histone H3 variants, replicative H3.1/2 or replacement H3.3, mark these domains during the cell ...
S. Arfè, T. Karagyozova, A. Forest, D. Bingham, H. Hmidan, D. Mazaud, M. Garnier, P. Le Baccon, E. Meshorer, J.-P. Quivy, G. Almouzni   +10 more
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Quantification of H3.1-nucleosomes using a chemiluminescent immunoassay: A reliable method for neutrophil extracellular trap detection. [PDF]

PLoS ONE
Neutrophil extracellular traps (NETs) are chromatin-based web-like structures released by activated neutrophils in response to infectious agents. Overproduction or insufficient clearance of NETs contributes to dysfunction of immune response and disease ...
Marion Wargnies, Guillaume Rommelaere, Julie Candiracci, Dorian Pamart, Robin Varsebroucq, Florian Jibassia, Finley Serneo, Virginie Laloux, Olivia Thiry, Fanny Lambert, Alison Lobbens, Priscilla Van den Ackerveken, Marielle Herzog   +12 more
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Dogs with sepsis are more hypercoagulable and have higher fibrinolysis inhibitor activities than dogs with non-septic systemic inflammation [PDF]

Frontiers in Veterinary Science
IntroductionHemostatic imbalance in dogs with sepsis is characterized by hypercoagulability and hypofibrinolysis. We aimed to determine whether these abnormalities are unique features of sepsis or are also present in dogs with non-septic critical illness.
Emily Hill, Yao Zhu, Marjory B. Brooks, Robert Goggs, Robert Goggs   +4 more
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Evaluation of plasma nucleosome concentrations and the effect of pre-analytical variables in healthy cats [PDF]

BMC Veterinary Research
Background Nucleosome levels have been shown to increase in dogs and humans in certain disease states, as a result of cell apoptosis, raising interest in their utility as a biomarker.
Emily Westerback, Heather Wilson-Robles, M’hammed Bougoussa, Stephanie Istvan, Samuel Stewart, Emma Warry, Justin Heinz   +6 more
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PRC1-mediated H2A.Zub promotes gene expression by preventing H3.1K27me1 incorporation in Arabidopsis [PDF]

Genome Biology
Background PcG complexes are pivotal in orchestrating the transition from embryonic to vegetative development in plants. However, the mechanisms underlying the gene expression reprogramming that takes place during this developmental transition are still ...
Fernando Baile, Javier Antúnez-Sánchez, José Gutiérrez-Marcos, Myriam Calonje   +3 more
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Single amino acid mutations in histone H3.3 illuminate the functional significance of H3K4 methylation in plants [PDF]

Nature Communications
Although histone modifications are linked with chromatin activities such as transcription, proofs of their causal importance remain limited. Sequence variants within each histone family expand chromatin diversity and may carry specific modifications ...
Mande Xue, Lijun Ma, Xiaoyi Li, Huairen Zhang, Fengyue Zhao, Qian Liu, Danhua Jiang   +6 more
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Histone H3.1 is a chromatin-embedded redox sensor triggered by tumor cells developing adaptive phenotypic plasticity and multidrug resistance [PDF]

Cell Reports
Summary: Chromatin structure is regulated through posttranslational modifications of histone variants that modulate transcription. Although highly homologous, histone variants display unique amino acid sequences associated with specific functions ...
Flavio R. Palma, Diego R. Coelho, Kirthi Pulakanti, Marcelo J. Sakiyama, Yunping Huang, Fernando T. Ogata, Jeanne M. Danes, Alison Meyer, Cristina M. Furdui, Douglas R. Spitz, Ana P. Gomes, Benjamin N. Gantner, Sridhar Rao, Vadim Backman, Marcelo G. Bonini   +14 more
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An exceptionally rare case of a diffuse midline glioma with concomitant H3.1 K27M and G34R mutations in the HIST1H3C (H3C3) gene [PDF]

Acta Neuropathologica Communications
Histone mutations (H3 K27M, H3 G34R/V) are molecular features defining subtypes of paediatric-type diffuse high-grade gliomas (HGG) (diffuse midline glioma (DMG), H3 K27-altered, diffuse hemispheric glioma (DHG), H3 G34-mutant).
Zita Reisz, Rita Pereira, Smitha Nevis, Alan Mackay, Leena Bhaw, Yura Grabovska, Ross Laxton, Valeria Molinari, Anna Burford, Barnaby Clark, Cristina Bleil, Bassel Zebian, Erika Pace, Annette Weiser, Fernando Carceller, Lynley Marshall, Andrew King, Istvan Bodi, Safa Al-Sarraj, Chris Jones, Matthew Clarke   +20 more
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