Results 21 to 30 of about 10,379 (180)

Citrullination of extracellular histone H3.1 reduces antibacterial activity and exacerbates its proteolytic degradation [PDF]

Journal of Cystic Fibrosis, 2021
Cystic fibrosis (CF), involves excessive airway accumulation of neutrophils, often in parallel with severe infection caused by Pseudomonas aeruginosa. Free histones are known to possess bactericidal properties, but the degree of antibacterial activity exerted on specific lung-based pathogens is largely unknown.
Lloyd Tanner, Ravi K.V. Bhongir, Christofer A.Q. Karlsson, Sandy Le, Johanna K. Ljungberg, Pia Andersson, Cecilia Andersson, Johan Malmström, Arne Egesten, Andrew B. Single   +9 more
openaire   +2 more sources

The in vivo Interaction Landscape of Histones H3.1 and H3.3

Molecular & Cellular Proteomics, 2022
Chromatin structure, transcription, DNA replication, and repair are regulated via locus-specific incorporation of histone variants and posttranslational modifications that guide effector chromatin-binding proteins. Here we report unbiased, quantitative interactomes for the replication-coupled (H3.1) and replication-independent (H3.3) histone H3 ...
Robert Siddaway, Scott Milos, Étienne Coyaud, Hwa Young Yun, Shahir M. Morcos, Sanja Pajovic, Eric I. Campos, Brian Raught, Cynthia Hawkins   +8 more
openaire   +4 more sources

SPT16 ubiquitylation by DCAF14-CRL4 regulates FACT binding to histones

Cell Reports, 2022
Summary: The histone chaperone complex FACT comprises SPT16 and SSRP1 and contributes to DNA replication, transcription, and repair, but how it plays such various roles is unclear.
Tadashi Nakagawa, Akane Morohoshi, Yuko Nagasawa, Makiko Nakagawa, Masaki Hosogane, Yasuhiro Noda, Toru Hosoi, Keiko Nakayama   +7 more
doaj   +1 more source

The program for processing newly synthesized histones H3.1 and H4 [PDF]

Nature Structural & Molecular Biology, 2010
The mechanism by which newly synthesized histones are imported into the nucleus and deposited onto replicating chromatin alongside segregating nucleosomal counterparts is poorly understood, yet this program is expected to bear on the putative epigenetic nature of histone post-translational modifications.
Campos, Eric I., Fillingham, Jeffrey, Li, Guohong, Zheng, Haiyan, Voigt, Philipp, Kuo, Wei-Hung W., Seepany, Harshika, Gao, Zhonghua, Day, Loren A., Greenblatt, Jack F., Reinberg, Danny   +10 more
openaire   +2 more sources

Dynamic replacement of histone H3 variants reprograms epigenetic marks in early mouse embryos. [PDF]

PLoS Genetics, 2011
Upon fertilization, reprogramming of gene expression is required for embryo development. This step is marked by DNA demethylation and changes in histone variant composition.
Tomohiko Akiyama, Osamu Suzuki, Junichiro Matsuda, Fugaku Aoki   +3 more
doaj   +1 more source

Stable inheritance of H3.3-containing nucleosomes during mitotic cell divisions

Nature Communications, 2022
How nucleosome assembly of parental histones is regulated following DNA replication is still an open question. Here the authors show that unlike deposition of new histones H3.1 and H3.3 that utilizes different histone chaperones, parental H3.1 and H3.3 ...
Xiaowei Xu, Shoufu Duan, Xu Hua, Zhiming Li, Richard He, Zhiguo Zhaang   +5 more
doaj   +1 more source

Sometimes Hot, Sometimes Not: The Relations Between Selected Situational Vocational Interests and Situation Perception

European Journal of Personality, EarlyView., 2020
Abstract Vocational interests are traditionally conceived as stable preferences for different activities. However, recent theorizing suggests their intraindividual variability. This preregistered experience sampling study examined intraindividual variation in selected vocational interests states and related situation and person factors (N = 237 ...
Lena Roemer, Kai T. Horstmann, Matthias Ziegler, Jan‐Erik Lönnqvist   +3 more
wiley   +1 more source

Histone exchange sensors reveal variant specific dynamics in mouse embryonic stem cells

Nature Communications, 2023
Eviction of histones from nucleosomes and their exchange with newly synthesized or alternative variants is a central epigenetic determinant. Here, we define the genome-wide occupancy and exchange pattern of canonical and non-canonical histone variants in
Marko Dunjić, Felix Jonas, Gilad Yaakov, Roye More, Yoav Mayshar, Yoach Rais, Ayelet-Hashahar Orenbuch, Saifeng Cheng, Naama Barkai, Yonatan Stelzer   +9 more
doaj   +1 more source

An acidic patch in the unstructured N-terminus modulates LSD1 activity. [PDF]

Protein Sci
Abstract Lysine‐specific demethylase 1 (LSD1) plays a crucial role in chromatin organization and gene regulation by removing methyl groups from histone and non‐histone substrates. While its catalytic core is well characterized, the functional contributions of its intrinsically disordered N‐terminal region remain less understood.
Dukatz F, Timofeev H, Schnee P, Rathert P.   +3 more
europepmc   +2 more sources

Selective Methylation of Histone H3 Variant H3.1 Regulates Heterochromatin Replication [PDF]

Science, 2014
Making a Histone Mark The covalent marks on histones (the principal components of chromatin) play a critical role in the regulation of gene expression. Somehow these marks are preserved when a cell in a tissue divides so that the daughter cells maintain the gene expression program and tissue identity of the parent
Yannick, Jacob, Elisa, Bergamin, Mark T A, Donoghue, Vanessa, Mongeon, Chantal, LeBlanc, Philipp, Voigt, Charles J, Underwood, Joseph S, Brunzelle, Scott D, Michaels, Danny, Reinberg, Jean-François, Couture, Robert A, Martienssen   +11 more
openaire   +2 more sources