Results 51 to 60 of about 10,379 (180)
An Essential Viral Transcription Activator Modulates Chromatin Dynamics. [PDF]
PLoS Pathogens, 2016 Although ICP4 is the only essential transcription activator of herpes simplex virus 1 (HSV-1), its mechanisms of action are still only partially understood.
Rebecca L Gibeault +3 more
doaj +1 more source
Analysis of the Histone H3.1 Interactome: A Suitable Chaperone for the Right Event [PDF]
Molecular Cell, 2015 Despite minimal disparity at the sequence level, mammalian H3 variants bind to distinct sets of polypeptides. Although histone H3.1 predominates in cycling cells, our knowledge of the soluble complexes that it forms en route to deposition or following eviction from chromatin remains limited. Here, we provide a comprehensive analysis of the H3.1-binding
CAmpos, E.I. +10 more
openaire +4 more sources
Proceedings of the National Academy of Sciences, 2022 Heterochromatin is essential for genomic integrity and stability in eukaryotes. The mechanisms that regulate meiotic heterochromatin formation remain largely undefined. Here, we show that the catalytic subunit (POL2A) ofArabidopsisDNA polymerase epsilon (POL ε) is required for proper formation of meiotic heterochromatin.
Cong Wang +10 more
openaire +2 more sources
BMC Veterinary Research, 2022 Background Cell free DNA, in the form of nucleosomes, is released into circulation during apoptosis and necrosis in a variety of diseases. They are small fragments of chromosomes that are composed of DNA wrapped around a histone core made of four ...
H. M. Wilson-Robles +8 more
doaj +1 more source
Emerging roles of telomeric chromatin alterations in cancer [PDF]
, 2019 Telomeres, the nucleoprotein structures that cap the ends of eukaryotic chromosomes, play important and multiple roles in tumorigenesis. Functional telomeres need the establishment of a protective chromatin structure based on the interplay between the ...
Biroccio, Annamaria +2 more
core +1 more source
Interactions With Histone H3 & Tools to Study Them
Frontiers in Cell and Developmental Biology, 2020 Histones are an integral part of chromatin and thereby influence its structure, dynamics, and functions. The effects of histone variants, posttranslational modifications, and binding proteins is therefore of great interest.
William A. Scott +3 more
doaj +1 more source
A pediatric bithalamic high grade glioma with concomitant H3K27M and EGFR mutations
The Turkish Journal of Pediatrics, 2022 Background. Despite many treatment approaches, survival rates in high grade glial tumors are still not at the desired level. One of the cause of this failure might be that although having similar histologic features, they may display different ...
Buket Kara +4 more
doaj +1 more source
Replication-Uncoupled Histone Deposition during Adenovirus DNA Replication [PDF]
, 2012 In infected cells, the chromatin structure of the adenovirus genome DNA plays critical roles in its genome functions. Previously, we reported that in early phases of infection, incoming viral DNA is associated with both viral core protein VII and ...
Komatsu Tetsuro +3 more
core +1 more source
Dynamics of Asymmetric and Symmetric Divisions of Muscle Stem Cells In Vivo and on Artificial Niches
Cell Reports, 2020 Summary: Stem cells can be maintained through symmetric cell divisions (SCDs) and asymmetric cell divisions (ACDs). How and when these divisions occur in vivo in vertebrates is poorly understood.
Brendan Evano +4 more
doaj +1 more source
Scientific Reports, 2023 During cell death, nucleosomes, the basic structural unit of chromatin, are released into the blood stream and elevated levels have been found in the plasma of patients with solid cancers.
Priscilla Van den Ackerveken +6 more
doaj +1 more source