Multilevel interrogation of H3.3 reveals a primordial role in transcription regulation
Epigenetics & Chromatin, 2023 Background Eukaryotic cells can rapidly adjust their transcriptional profile in response to molecular needs. Such dynamic regulation is, in part, achieved through epigenetic modifications and selective incorporation of histone variants into chromatin. H3.
Syed Nabeel-Shah +12 more
doaj +1 more source
Realizations of Galilei algebras
, 2016 All inequivalent realizations of the Galilei algebras of dimensions not greater than five are constructed using the algebraic approach proposed by I. Shirokov.
Nesterenko, Maryna +2 more
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On the path-independence of the Girsanov transformation for stochastic evolution equations with jumps in Hilbert spaces [PDF]
, 2019 Based on a recent result in [14], in this paper, we extend it to stochas- tic evolution equations with jumps in Hilbert spaces. This is done via Galerkin type finite-dimensional approximations of the infinite-dimensional stochastic evolution equa- tions ...
Jiang-lun Wu
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Histone H3.1 and H3.3 Complexes Mediate Nucleosome Assembly Pathways Dependent or Independent of DNA Synthesis [PDF]
Cell, 2004 Deposition of the major histone H3 (H3.1) is coupled to DNA synthesis during DNA replication and possibly DNA repair, whereas histone variant H3.3 serves as the replacement variant for the DNA-synthesis-independent deposition pathway. To address how histones H3.1 and H3.3 are deposited into chromatin through distinct pathways, we have purified ...
Tagami, Hideaki +3 more
openaire +3 more sources
Stochastic Differential Games and Viscosity Solutions of Hamilton-Jacobi-Bellman-Isaacs Equations
, 2007 In this paper we study zero-sum two-player stochastic differential games with the help of theory of Backward Stochastic Differential Equations (BSDEs). At the one hand we generalize the results of the pioneer work of Fleming and Souganidis by considering
Buckdahn, Rainer, Li, Juan
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Using patient-reported measures to drive change in healthcare: the experience of the digital, continuous and systematic PREMs observatory in Italy [PDF]
, 2020 BACKGROUND: The use of Patient Reported Experience Measures (PREMs) has great potential in healthcare service improvement, but a limited use. This paper presents an empirical case of PREMs innovation in Italy, to foster patient data use up to the ward ...
Cerasuolo, D., De Rosis, S., Nuti, S.
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The Role of the TSK/TONSL-H3.1 Pathway in Maintaining Genome Stability in Multicellular Eukaryotes
International Journal of Molecular Sciences, 2022 Replication-dependent histone H3.1 and replication-independent histone H3.3 are nearly identical proteins in most multicellular eukaryotes. The N-terminal tails of these H3 variants, where the majority of histone post-translational modifications are made, typically differ by only one amino acid. Despite extensive sequence similarity with H3.3, the H3.1
Yi-Chun Huang +2 more
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Mutations of H3.3 and H3.1 in a large cohort of glioma tumors. [PDF]
Journal of Clinical Oncology, 2019 e13540 Background: Mutations in the histone genes H3.3 and H3.1 are driver events in pediatric and adult gliomas and carry diagnostic and prognostic importance for tumors originating from midline structures. Patients with tumors affected by these mutations are notoriously difficult to treat, and the prevalence and molecular correlates of H3 mutations
Ashley Love Sumrall +9 more
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Chromatin structure-dependent histone incorporation revealed by a genome-wide deposition assay
eLife, 2021 In eukaryotes, histone variant distribution within the genome is the key epigenetic feature. To understand how each histone variant is targeted to the genome, we developed a new method, the RhIP (Reconstituted histone complex Incorporation into chromatin
Hiroaki Tachiwana +9 more
doaj +1 more source
New histone supply regulates replication fork speed and PCNA unloading [PDF]
, 2013 International ...
Alabert, Constance +10 more
core +5 more sources