Local nuclear to cytoplasmic ratio regulates H3.3 incorporation via cell cycle state during zygotic genome activation [PDF]
EMBO ReportsEarly embryos often have unique chromatin states prior to zygotic genome activation (ZGA). In Drosophila, ZGA occurs after 13 reductive nuclear divisions during which the nuclear to cytoplasmic (N/C) ratio grows exponentially.
Anusha D Bhatt +4 more
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Phosphorylation-mimicking histone H3.3 rescues exercise-induced gene responses in an epigenetic aging model of mouse skeletal muscle [PDF]
Laboratory Animal ResearchBackground With aging, the canonical histone H3.1/3.2 in skeletal muscle is progressively replaced by the non-canonical variant H3.3. Although H3.3 is thought to be involved in age-related epigenetic regulation due to its role as a histone variant, its ...
Sho Maruyama, Fuminori Kawano
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Implications of canonical histone H3.1 and histone variant H3.3 in cancer [PDF]
Open BiologyHistones are the fundamental building blocks of chromatin and serve as pivotal regulators of gene expression. Differential expression and mutations of H3.1 and H3.3 genes have been implicated in the pathogenesis of various cancer types. Mutations in H3.3,
Peng Wu, Li Wang, Ting Wen, Qiao Yi Chen
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Single amino acid mutations in histone H3.3 illuminate the functional significance of H3K4 methylation in plants [PDF]
Nature CommunicationsAlthough histone modifications are linked with chromatin activities such as transcription, proofs of their causal importance remain limited. Sequence variants within each histone family expand chromatin diversity and may carry specific modifications ...
Mande Xue +6 more
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H3.3-H4 tetramer splitting events feature cell-type specific enhancers. [PDF]
PLoS Genetics, 2013 Previously, we reported that little canonical (H3.1-H4)(2) tetramers split to form "hybrid" tetramers consisted of old and new H3.1-H(4) dimers, but approximately 10% of (H3.3-H4)2 tetramers split during each cell cycle.
Chang Huang +7 more
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Dynamic deposition of histone variant H3.3 accompanies developmental remodeling of the Arabidopsis transcriptome. [PDF]
PLoS Genetics, 2012 In animals, replication-coupled histone H3.1 can be distinguished from replication-independent histone H3.3. H3.3 variants are enriched at active genes and their promoters. Furthermore, H3.3 is specifically incorporated upon gene activation.
Heike Wollmann +5 more
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Histone H3 methylation orchestrates transcriptional program in mouse spermatogenic cell line
The Journal of Reproduction and Development, 2020 Changes in histone modifications always correlate with altered transcriptional activities of genes. Recent studies have shown that the mutation of certain lysine residues to methionine in the histone variant H3.3 can act as a valuable tool to reduce ...
Xiao-fei WANG +7 more
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Stage-specific histone modification profiles reveal global transitions in the Xenopus embryonic epigenome. [PDF]
, 2011 Vertebrate embryos are derived from a transitory pool of pluripotent cells. By the process of embryonic induction, these precursor cells are assigned to specific fates and differentiation programs.
Arteaga-Salas, Jose M. +6 more
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H3.3 kinetics predicts chromatin compaction status of parental genomes in early embryos
Reproductive Biology and Endocrinology, 2021 Background After fertilization, the fusion of gametes results in the formation of totipotent zygote. During sperm-egg fusion, maternal factors participate in parental chromatin remodeling.
Shi-meng Guo +2 more
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Genome Biology, 2023 Background The histone variant H3.3 is enriched at active regulatory elements such as promoters and enhancers in mammalian genomes. These regions are highly accessible, creating an environment that is permissive to transcription factor binding and the ...
Amanuel Tafessu +6 more
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