Results 91 to 100 of about 16,775 (201)

Rpp29 regulates histone H3.3 chromatin assembly through transcriptional mechanisms [PDF]

Journal of Biological Chemistry, 2018
The histone H3 variant H3.3 is a highly conserved and dynamic regulator of chromatin organization. Therefore, fully elucidating its nucleosome incorporation mechanisms is essential to understanding its functions in epigenetic inheritance. We previously identified the RNase P protein subunit, Rpp29, as a repressor of H3.3 chromatin assembly.
Prashanth Krishna Shastrula, Peder J. Lund, Benjamin A. Garcia, Susan M. Janicki   +3 more
openaire   +2 more sources

Morphine Tolerance Gated through EZH2‐Mediated Suppression of Trpc5 in Spinal GABAergic Interneurons in Male Mice

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Chronic morphine suppresses Trpc5 in spinal GABAergic interneurons via EZH2‐mediated histone modification, reducing Ca2+ influx and GABA release. TRPC5 activation enhances morphine analgesia, while EZH2 inhibition restores efficacy and reverses tolerance.
Li Wan, Mengyao Zhang, Haiyue Guo, Yan Xu, Chenjie Xu, Fan Hu, Yinbing Pan, Xian Wang, Wentao Liu, Chun‐Yi Jiang   +9 more
wiley   +1 more source

Agricultural Production Diversity and Market Participation Can Absorb the Impact of Shocks on Household Food Security

Food and Energy Security, Volume 15, Issue 1, January/February 2026.
ABSTRACT Bangladesh is highly exposed to recurrent covariate and idiosyncratic shocks that pose persistent threats to household food security. This study examines whether agricultural production diversity and market participation can mitigate the adverse effects of such shocks on food security.
Md. Salman, Shihab Uddin Ahmad, Jincheng Zhang, Md Abdur Rouf Sarkar   +3 more
wiley   +1 more source

ARID1A-dependent maintenance of H3.3 is required for repressive CHD4-ZMYND8 chromatin interactions at super-enhancers

BMC Biology, 2022
Background SWI/SNF (BAF) chromatin remodeling complexes regulate lineage-specific enhancer activity by promoting accessibility for diverse DNA-binding factors and chromatin regulators.
Jake J. Reske, Mike R. Wilson, Brooke Armistead, Shannon Harkins, Cristina Perez, Joel Hrit, Marie Adams, Scott B. Rothbart, Stacey A. Missmer, Asgerally T. Fazleabas, Ronald L. Chandler   +10 more
doaj   +1 more source

Astrocytic Chromatin Remodeler ATRX Gates Hippocampal Memory Consolidation Through Metabolic and Synaptic Regulation

Glia, Volume 74, Issue 1, January 2026.
Astrocytic ATRX loss causes non‐cell‐autonomous neuronal hyperexcitability. Inducing ATRX deficiency in astrocytes causes selective long‐term memory deficits. Dynamic transcriptomic changes reveal metabolic and synaptic pathway dysregulation. ABSTRACT Astrocytes are increasingly recognized as active regulators of synaptic transmission and memory, yet ...
Miguel A. Pena‐Ortiz, Julia K. Sunstrum, Alireza Ghahramani, Haley McConkey, Vanessa Dumeaux, Wataru Inoue, Nathalie G. Bérubé   +6 more
wiley   +1 more source

CENP-B protects centromere chromatin integrity by facilitating histone deposition via the H3.3-specific chaperone Daxx

Epigenetics & Chromatin, 2017
Background The main chromatin unit, the nucleosome, can be modulated by the incorporation of histone variants that, in combination with posttranslational histones modifications, determine epigenetics properties of chromatin.
Viacheslav M. Morozov, Serena Giovinazzi, Alexander M. Ishov   +2 more
doaj   +1 more source

Histone Hypervariants H2A.Z.1 and H2A.Z.2 Play Independent and Context-Specific Roles in Neuronal Activity-Induced Transcription of Arc/Arg3.1 and Other Immediate Early Genes. [PDF]

, 2017
The histone variant H2A.Z is an essential and conserved regulator of eukaryotic gene transcription. However, the exact role of this histone in the transcriptional process remains perplexing.
Bailey, Emma R, Dudek, Serena M, Dunn, Carissa J, Farris, Shannon, Saha, Ramendra N, Sarkar, Pushpita, Ward, James M, Zhao, Meilan   +7 more
core   +1 more source

cIMPACT‐NOW update 11: Proposal on adaptation of diagnostic criteria for IDH‐ and H3‐wildtype diffuse high‐grade gliomas and for posterior fossa ependymal tumors

Brain Pathology, Volume 36, Issue 1, January 2026.
Abstract The Consortium to Inform Molecular and Practical Approaches to Central Nervous System Tumor Taxonomy (cIMPACT‐NOW) updates provide guidelines for the diagnosis of central nervous system (CNS) tumors and suggestions for future World Health Organization (WHO) classification.
Pieter Wesseling, David Capper, Guido Reifenberger, Chitra Sarkar, Cynthia Hawkins, Arie Perry, Bette Kleinschmidt‐DeMasters, Takashi Komori, Werner Paulus, Vani Santosh, Martin van den Bent, Michael Weller, Stefan M. Pfister, Uri Tabori, Dominique Figarella‐Branger, Brent A. Orr, David N. Louis   +16 more
wiley   +1 more source

Molecular turnover, the H3.3 dilemma and organismal aging (hypothesis) [PDF]

Aging Cell, 2015
SummaryThe H3.3 histone variant has been a subject of increasing interest in the field of chromatin studies due to its two distinguishing features. First, its incorporation into chromatin is replication independent unlike the replication‐coupled deposition of its canonical counterparts H3.1/2.
Saade, Evelyne, Pirozhkova, Iryna, Aimbetov, Rakhan, Lipinski, Marc, Ogryzko, Vasily   +4 more
openaire   +2 more sources

Histone variant H3.3 and its future prospects in cancer clinic

Journal of Radiation and Cancer Research, 2017
Histone variant, H3.3 has been a continuous subject of interest in the field of chromatin studies due to its two distinguishing features. First, its incorporation into chromatin is replication-independent, unlike the replication-coupled deposition of its
Divya Reddy, Sanjay Gupta
doaj   +1 more source