Results 101 to 110 of about 16,775 (201)

Polyadenylation of Histone H3.1 mRNA Promotes Cell Transformation by Displacing H3.3 from Gene Regulatory Elements

iScience, 2020
Summary: Replication-dependent canonical histone messenger RNAs (mRNAs) do not terminate with a poly(A) tail at the 3′ end. We previously demonstrated that exposure to arsenic, an environmental carcinogen, induces polyadenylation of canonical histone H3 ...
Danqi Chen, Qiao Yi Chen, Zhenjia Wang, Yusha Zhu, Thomas Kluz, Wuwei Tan, Jinquan Li, Feng Wu, Lei Fang, Xiaoru Zhang, Rongquan He, Steven Shen, Hong Sun, Chongzhi Zang, Chunyuan Jin, Max Costa   +15 more
doaj   +1 more source

Epigenetic aberrations and cancer [PDF]

, 2006
The correlation between epigenetic aberrations and disease underscores the importance of epigenetic mechanisms.
Brown, Mark A., Ducasse, Miryam
core   +3 more sources

Comparing the Assembly and Handedness Dynamics of (H3.3-H4)2 Tetrasomes to Canonical Tetrasomes.

PLoS ONE, 2015
Eukaryotic nucleosomes consists of an (H3-H4)2 tetramer and two H2A-H2B dimers, around which 147 bp of DNA are wrapped in 1.7 left-handed helical turns.
Rifka Vlijm, Mina Lee, Orkide Ordu, Anastasiya Boltengagen, Alexandra Lusser, Nynke H Dekker, Cees Dekker   +6 more
doaj   +1 more source

Metabolic Interplay in Acute Lung Injury: PARK7 Integrates FADS1/2‐Dependent PUFA Metabolism and H3K14 Lactylation to Attenuate Endothelial Ferroptosis and Dysfunction

Advanced Science, Volume 12, Issue 46, December 11, 2025.
SCAP/ARDS patients show reduced unsaturated fatty acids (UFAs) but higher PARK7 and lactate in plasma. PARK7 correlates positively with lactate and negatively with UFAs. Pulmonary endothelial cell multi‐omics show FADS1/2 downregulation and impaired PUFA metabolism. Lactate boosts PARK7 via H3K14 lactylation, and PARK7 then restores FADS1/2.
Jian Xu, Yuhan Wang, Weiqi Mao, Tianchang Wei, Yufan Li, Juan Song, Cuiping Zhang, Xiaoyan Chen, Cuicui Chen, Qingyuan Xu, Xu Wu, Yuanlin Song   +11 more
wiley   +1 more source

Transposable Elements, Inflammation, and Neurological Disease. [PDF]

, 2019
Transposable Elements (TE) are mobile DNA elements that can replicate and insert themselves into different locations within the host genome. Their propensity to self-propagate has a myriad of consequences and yet their biological significance is not well-
Macia, Angela, Muotri, Alysson R, Saleh, Aurian   +2 more
core  

Victims of Conspiracies? An Examination of the Relationship Between Conspiracy Beliefs and Dispositional Individual Victimhood

European Journal of Social Psychology, Volume 55, Issue 7, Page 1252-1269, December 2025.
ABSTRACT Conspiracy beliefs have been linked to perceptions of collective victimhood. We adopt an individual perspective on victimhood by investigating the relationship between conspiracy beliefs and the individual disposition to perceive and react to injustice as a victim, i.e., victim justice sensitivity (VJS). Data from two German samples (Ns = 370,
Daniel Toribio‐Flórez, Marlene S. Altenmüller, Karen M. Douglas, Mario Gollwitzer, Indro Adinugroho, Mark Alfano, Denisa Apriliawati, Flavio Azevedo, Cornelia Betsch, Olga Białobrzeska, Amélie Bret, André Calero Valdez, Viktoria Cologna, Gabriela Czarnek, Sylvain Delouvée, Kimberly C. Doell, Simone Dohle, Dmitrii Dubrov, Małgorzata Dzimińska, Christian T. Elbaek, Matthew Facciani, Antoinette Fage‐Butler, Marinus Ferreira, Malte Friese, Simon Fuglsang, Albina Gallyamova, Patricia Garrido‐Vásquez, Mauricio E. Garrido Vásquez, Oliver Genschow, Omid Ghasemi, Theofilos Gkinopoulos, Claudia González Brambila, Hazel Clare Gordon, Dmitry Grigoryev, Alma Cristal Hernández‐Mondragón, Tao Jin, Sebastian Jungkunz, Dominika Jurgiel, John R. Kerr, Lilian Kojan, Elizaveta Komyaginskaya, Claus Lamm, Jean‐Baptiste Légal, Neil Levy, Mathew D. Marques, Sabrina J. Mayer, Niels G. Mede, Taciano L. Milfont, Panagiotis Mitkidis, Jonas P. Nitschke, Mariola Paruzel‐Czachura, Michal Parzuchowski, Ekaterina Pronizius, Katarzyna Pypno‐Blajda, Gabriel Gaudencio Rêgo, Robert M. Ross, Philipp Schmid, Samantha K. Stanley, Stylianos Syropoulos, Ewa Szumowska, Claudia Teran‐Escobar, Boryana Todorova, Iris Vilares, Izabela Warwas, Marcel Weber, Mareike Westfal, Adrian Dominik Wojcik   +66 more
wiley   +1 more source

A functional SUMO-motif in the active site of PIM1 promotes its degradation via RNF4, and stimulates protein kinase activity [PDF]

, 2017
The PIM1 serine/threonine protein kinase mediates growth factor and survival signalling, and cooperates potently with c-MYC during tumorigenesis. PIM1 is overexpressed in many human cancers and is a promising target for drug development.
A Denuc, A Telerman, A Zippo, AM Jacobs, B Liu, BS Kang, C Blanco-Aparicio, C Hogan, CD Chung, CF Cruz-Herrera de la, CF Cruz-Herrera de la, CH Lin, CK Palaty, D Horiuchi, ES Johnson, F Braso-Maristany, F Geng, F Huang, G Gill, I Aukrust, J Ma, J Wang, JA Losman, JA Muraski, JF Maure, K Mizuno, KP Shay, L Brault, L Marcar, LN Shen, MC Geoffroy, MC Nawijn, MH Tatham, MS Rodriguez, NA Warfel, R Amson, R Li, R Padma, RT Hay, TL Aho, Y Kubota, Y Yan, Y Zhang, Z Galcheva-Gargova, Z Lu   +44 more
core   +2 more sources

Using Eye Movements to Understand Sense of Control in Situated Action

Cognitive Science, Volume 49, Issue 12, December 2025.
Abstract This series of studies investigated the interplay between the Sense of Control, continuous action control, and eye‐movement behavior in dynamic and uncertain environments. Across three experiments, we used a custom‐designed environment combined with eye‐tracking to examine how action goal pursuit and visual strategies were adapted to deal with
Nils Wendel Heinrich, Annika Österdiekhoff, Stefan Kopp, Nele Russwinkel   +3 more
wiley   +1 more source

Structural and Biochemical Characterization of the Nucleosome Containing Variants H3.3 and H2A.Z

Epigenomes
Variant H3.3, along with H2A.Z, is notably enriched at promoter regions and is commonly associated with transcriptional activation. However, the specific molecular mechanisms through which H3.3 influences chromatin dynamics at transcription start sites ...
Harry Jung, Vladyslava Sokolova, Gahyun Lee, Victoria Rose Stevens, Dongyan Tan   +4 more
doaj   +1 more source

Replication-Independent Histone Variant H3.3 Controls Animal Lifespan through the Regulation of Pro-longevity Transcriptional Programs

Cell Reports, 2016
Chromatin structure orchestrates the accessibility to the genetic material. Replication-independent histone variants control transcriptional plasticity in postmitotic cells.
Antonia Piazzesi, Dražen Papić, Fabio Bertan, Paolo Salomoni, Pierluigi Nicotera, Daniele Bano   +5 more
doaj   +1 more source