Results 121 to 130 of about 16,775 (201)

The HIRA complex that deposits the histone H3.3 is conserved in Arabidopsis and facilitates transcriptional dynamics

Biology Open, 2014
In animals, replication-independent incorporation of nucleosomes containing the histone variant H3.3 enables global reprogramming of histone modifications and transcriptional profiles.
Xin Nie, Haifeng Wang, Jing Li, Sarah Holec, Frédéric Berger   +4 more
doaj   +1 more source

Dynamic distribution of the replacement histone variant H3.3 in the mouse oocyte and preimplantation embryos [PDF]

, 2006
Upon fertilization, the gametes undergo a drastic reprogramming that includes changes in DNA methylation and histone modifications. Currently, it is not known whether replacement of the major histones by histone variants is also involved in these ...
Bannister, Andrew J., Hurd, Paul J., Kouzarides, Tony, Torres-Padilla, Maria-Elena, Zernicka-Goetz, Magdalena   +4 more
core  

Histone H3.3 Mutations Are Cancer Type-Specific [PDF]

Cancer Discovery, 2013
Abstract Most chondroblastomas have H3F3B mutations, but giant cell tumors only have mutations in H3F3A.
openaire   +1 more source

Immunohistochemical expression of H3.3 G34W in 100 giant cell tumors of bone and its diagnostic mimics, including its value in resolving uncommon diagnostic scenarios: A single institutional study at a tertiary cancer referral center, India

Indian Journal of Pathology and Microbiology
Background: There can be a diagnostic challenge in differentiating giant cell tumor of bone (GCTB) from its mimics. Lately, histone H3F3A (Histone 3.3) G34W has been identified as a promising immunohistochemical marker.
Bharat Rekhi, Vinayak Dave, Ashwin Butle, Bhasker Dharavath, Sonali Khetale, Archana K. Redhu, Rudransh Singh, Amit Dutt   +7 more
doaj   +1 more source

Genetically Engineered T-Cells for Malignant Glioma: Overcoming the Barriers to Effective Immunotherapy. [PDF]

, 2018
Malignant gliomas carry a dismal prognosis. Conventional treatment using chemo- and radiotherapy has limited efficacy with adverse events. Therapy with genetically engineered T-cells, such as chimeric antigen receptor (CAR) T-cells, may represent a ...
Almeida, Neil D, Chuntova, Pavlina, Downey, Kira M, Hegde, Bindu, Okada, Hideho   +4 more
core  

H3.3 recovers transcription [PDF]

Nature Reviews Genetics, 2013
openaire   +1 more source

Histone H3.3 [PDF]

, 2020
openaire   +1 more source

Histone H3.3 beyond cancer

Germ line mutations in H3F3A and H3F3B cause a previously unidentified neurodevelopmental syndrome. Although somatic mutations in Histone 3.3 (H3.3) are well-studied drivers of oncogenesis, the role of germline mutations remains unreported. We analyze 46 patients bearing de novo germline mutations in histone 3 family 3A (H3F3A) or H3F3B with ...
Bryant, Laura||, Li, Dong||, Cox, Samuel G., Marchione, Dylan, Joiner, Evan F., Wilson, Khadija, Janssen, Kevin, Lee, Pearl, March, Michael E., Nair, Divya, Sherr, Elliott||, Fregeau, Brieana, Wierenga, Klaas J., Wadley, Alexandrea, Mancini, Grazia M. S., Powell-Hamilton, Nina, van de Kamp, Jiddeke, Grebe, Theresa, Dean, John||, Ross, Alison, Crawford, Heather P., Powis, Zoe, Cho, Megan T., Willing, Marcia C., Manwaring, Linda, Schot, Rachel, Nava, Caroline||, Afenjar, Alexandra, Lessel, Davor||, Wagner, Matias, Klopstock, Thomas||, Winkelmann, Juliane, Catarino, Claudia B., Retterer, Kyle, Schuette, Jane L., Innis, Jeffrey W., Pizzino, Amy, Lüttgen, Sabine, Denecke, Jonas, Strom, Tim M., Monaghan, Kristin G., Yuan, Zuo-Fei, Dubbs, Holly, Bend, Renee, Lee, Jennifer A., Lyons, Michael J., Hoefele, Julia||, Günthner, Roman, Reutter, Heiko, Keren, Boris, Radtke, Kelly, Sherbini, Omar, Mrokse, Cameron, Helbig, Katherine L., Odent, Sylvie, Cogne, Benjamin, Mercier, Sandra, Bezieau, Stephane, Besnard, Thomas, Küry, Sébastien||, Redon, Richard||, Reinson, Karit, Wojcik, Monica H., Õunap, Katrin, Ilves, Pilvi, Innes, A. Micheil, Kernohan, Kristin D., Costain, Gregory||, Meyn, M. Stephen, Chitayat, David, Zackai, Elaine, Lehman, Anna, Kitson, Hilary, Martin, Martin G., Martinez-Agosto, Julian A., Nelson, Stan F., Palmer, Christina G. S., Papp, Jeanette C., Parker, Neil H., Sinsheimer, Janet S., Vilain, Eric, Wan, Jijun, Yoon, Amanda J., Zheng, Allison, Brimble, Elise, Ferrero, Giovanni Battista||, Radio, Francesca Clementina, Carli, Diana, Barresi, Sabina, Brusco, Alfredo||, Tartaglia, Marco, Thomas, Jennifer Muncy, Umana, Luis, Weiss, Marjan M., Gotway, Garrett, Stuurman, K. E., Thompson, Michelle L., McWalter, Kirsty||, Stumpel, Constance T. R. M., Stevens, Servi J. C.||, Stegmann, Alexander P. A., Tveten, Kristian, Vøllo, Arve, Prescott, Trine, Fagerberg, Christina, Laulund, Lone Walentin, Larsen, Martin J., Byler, Melissa, Lebel, Robert Roger, Hurst, Anna C., Dean, Joy, Schrier Vergano, Samantha A., Norman, Jennifer, Mercimek-Andrews, Saadet, Neira, Juanita, Van Allen, Margot I., Longo, Nicola, Sellars, Elizabeth, Louie, Raymond J., Cathey, Sara S., Brokamp, Elly, Heron, Delphine, Snyder, Molly, Vanderver, Adeline, Simon, Celeste, de la Cruz, Xavier||, Padilla Sirera, Natàlia||, Crump, J. Gage||, Chung, Wendy, Garcia, Benjamin, Hakonarson, Hakon||, Bhoj, Elizabeth J.||   +131 more
openaire   +1 more source

A Rare Pediatric Giant Cell Tumor of the Clivus Bone, H3.3 p.Gly35Trp-mutated: Case Report and Mini-review of the Literature

Turkish Archives of Pediatrics
Introduction: Giant cell tumor of bone (GCTB) is a rare, typically benign neoplasm that primarily affects long bones in adults, with clival involvement being extremely rare, particularly in pediatric cases: a mini-review shows a total of 28 described ...
Gabriele Gaggero, Teresa Battaglia, Virginia Andreotti, Andrea Rossi, Marta Ingaliso, Davide Taietti, Claudia Milanaccio, Gianluca Piatelli, Valerio Gaetano Vellone   +8 more
doaj   +1 more source

ARID1A governs the silencing of sex-linked transcription during male meiosis in the mouse

eLife
We present evidence implicating the BAF (BRG1/BRM Associated Factor) chromatin remodeler in meiotic sex chromosome inactivation (MSCI). By immunofluorescence (IF), the putative BAF DNA binding subunit, ARID1A (AT-rich Interaction Domain 1 a), appeared ...
Debashish U Menon, Prabuddha Chakraborty, Noel Murcia, Terry Magnuson   +3 more
doaj   +1 more source