Results 191 to 200 of about 16,775 (201)

Characterization of an unusual human histone H3.3 pseudogene

DNA Sequence, 1991
The analysis of a genomic loci containing human histone H3.3 processed pseudogenes, has revealed two regions that are unusually rich in other retroposons. At one of the loci the H3.3 pseudogene is itself interrupted by 2 Alu repetitive sequences. The characterization of these two recently transposed Alus provides confirmation of the "multiple origin ...
D, Wells, W, Bains
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H3.3 impedes zygotic transcriptional program activated by Dux

Biochemical and Biophysical Research Communications, 2020
During development, fertilization triggers totipotency establishment, featured by zygotic genome activation/embryonic genome activation (ZGA/EGA). Mouse embryonic stem cells (mESCs) occasionally cycle through a two-cell (2C)-like status with activated expression of Dux and its targeted ZGA genes.
Qing Tian, Xiao-fei Wang, Shi-ming Xie, Ying Yin, Li-quan Zhou   +4 more
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Recurrent H3.3 alterations in childhood tumors

Nature Genetics, 2013
Comprehensive sequencing of benign and malignant tumors has recently uncovered new driver mutations in childhood tumors. A new report now describes frequent histone H3.3 alterations in chondroblastoma and giant cell tumor of bone, emphasizing the importance of this histone variant in pediatric cancers.
Anders M Lindroth, Christoph Plass
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Epigenetic memory: H3.3 steps in the groove

Nature Cell Biology, 2008
Successful animal cloning after nuclear transfer requires efficient reprogramming to achieve totipotency. Erasure of pre-existing marks is not always efficient and some genes can escape reprogramming and maintain their original active transcriptional state. Ng and Gurdon propose that the histone H3.3 variant is a key player in this process.
Nicolas Lacoste, Geneviève Almouzni
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H3.3 safeguards haematopoietic ERV-quilibrium

Nature Cell Biology, 2021
Nadia Omega Cipta, Ying Chen, Yuin-Han Loh   +2 more
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Indolent course of brainstem tumors with K27M‐H3.3 mutation

Pediatric Blood & Cancer, 2019
AbstractDiffuse intrinsic pontine glioma (DIPG) is characterized by a short history of brainstem symptoms and well‐known magnetic resonance imaging features with a fatal outcome. However, we report three unusual cases of brainstem tumors with an initial indolent and protracted course, which subsequently developed the classical imaging and clinical ...
Lorena V. Baroni, Palma Solano‐Paez, Liana Nobre, Orli Michaeli, Cynthia Hawkins, Suzanne Laughlin, Ute Bartels, Vijay Ramaswamy, Eric Bouffet   +8 more
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Driver mutations in histone H3.3 and chromatin

2012
Glioblastoma multiforme (GBM) is a lethal brain tumour in adults and children. However, DNA copy number and gene expression signatures indicate differences between adult and paediatric cases. To explore the genetic events underlying this distinction, we sequenced the exomes of 48 paediatric GBM samples. Somatic mutations in the H3.3-ATRX-DAXX chromatin
Schwartzentruber, Jeremy, Korshunov, Andrey, Liu, Xiao-Yang, Jones, David T. W., Pfaff, Elke, Jacob, Karine, Sturm, Dominik, Fontebasso, Adam M., Khuong Quang, Dong-Anh, Tönjes, Martje, Hovestadt, Volker, Albrecht, Steffen, Kool, Marcel, Nantel, Andre, Konermann, Carolin, Lindroth, Anders, Jäger, Natalie, Rausch, Tobias, Ryzhova, Marina, Korbel, Jan O., Hielscher, Thomas, Hauser, Peter, Garami, Miklos, Klekner, Almos, Bognar, Laszlo, Ebinger, Martin, Schuhmann, Martin U., Scheurlen, Wolfram, Pekrun, Arnulf, Frühwald, Michael C., Roggendorf, Wolfgang, Kramm, Christoph, Dürken, Matthias, Atkinson, Jeffrey, Lepage, Pierre, Montpetit, Alexandre, Zakrzewska, Magdalena, Zakrzewski, Krzystof, Liberski, Pawel P., Dong, Zhifeng, Siegel, Peter, Kulozik, Andreas E., Zapatka, Marc, Guha, Abhijit, Malkin, David, Felsberg, Jörg, Reifenberger, Guido, von Deimling, Andreas, Ichimura, Koichi, Collins, V. Peter, Witt, Hendrik, Milde, Till, Witt, Olaf, Zhang, Cindy, Castelo-Branco, Pedro, Lichter, Peter, Faury, Damien, Tabori, Uri, Plass, Christoph, Majewski, Jacek, Pfister, Stefan M., Jabado, Nada   +61 more
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[The H3.3 K36M mutation protein expression of H3.3 in chondroblastoma: a novel diagnostic biomarker].

Zhonghua bing li xue za zhi = Chinese journal of pathology, 2021
L H, Gong, W, Zhang, R F, Dong, T T, Zhang, X Q, Sun, M, Zhang, Y, Ding   +6 more
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Histone H3.3 mutations alter development

Science, 2020
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H3.3 Strömungssieden – Druckverlust in durchströmten Verdampferrohren

2019
Matthias Kind, Thomas Wetzel
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