Histone H3.3 variant dynamics in the germline of Caenorhabditis elegans. [PDF]
PLoS Genetics, 2006 Germline chromatin undergoes dramatic remodeling events involving histone variants during the life cycle of an organism. A universal histone variant, H3.3, is incorporated at sites of active transcription throughout the cell cycle.
Siew Loon Ooi +2 more
doaj +1 more source
Emerging roles of telomeric chromatin alterations in cancer [PDF]
, 2019 Telomeres, the nucleoprotein structures that cap the ends of eukaryotic chromosomes, play important and multiple roles in tumorigenesis. Functional telomeres need the establishment of a protective chromatin structure based on the interplay between the ...
Biroccio, Annamaria +2 more
core +1 more source
Distribution of histone H3.3 in hematopoietic cell lineages [PDF]
Proceedings of the National Academy of Sciences, 2006 We have introduced the histone variant H3.3 into chicken erythroid cell lines and examined its distribution in the neighborhood of the folate receptor (FR) and β-globin genes by using high-resolution chromatin immunoprecipitation (ChIP). Marked incorporation of tagged H3.3 into the FR gene is confined to its upstream regulatory region and ...
Chunyuan, Jin, Gary, Felsenfeld
openaire +2 more sources
Differential effect of histone H3.3 depletion on retroviral repression in embryonic stem cells
Clinical Epigenetics, 2023 Background Integration of retroviruses into the host genome can impair the genomic and epigenomic integrity of the cell. As a defense mechanism, epigenetic modifications on the proviral DNA repress retroviral sequences in mouse embryonic stem cells (ESC).
Ayellet Tal +4 more
doaj +1 more source
Pediatric glioma histone H3.3 K27M/G34R mutations drive abnormalities in PML nuclear bodies
Genome Biology, 2023 Background Point mutations in histone variant H3.3 (H3.3K27M, H3.3G34R) and the H3.3-specific ATRX/DAXX chaperone complex are frequent events in pediatric gliomas.
Hsiao P. J. Voon +17 more
doaj +1 more source
A more accurate analysis of maternal effect genes by siRNA electroporation into mouse oocytes
The Journal of Reproduction and Development, 2023 Maternal RNA and proteins accumulate in mouse oocytes and regulate initial developmental stages. Sperm DNA combines with protamine, which is exchanged after fertilization with maternal histones, including H3.3; however, the effect of H3.3 on development ...
Takuto YAMAMOTO +5 more
doaj +1 more source
Maximum principle for a stochastic delayed system involving terminal state constraints [PDF]
, 2017 We investigate a stochastic optimal control problem where the controlled system is depicted as a stochastic differential delayed equation; however, at the terminal time, the state is constrained in a convex set.
Shi, Yufeng, Wen, Jiaqiang
core +3 more sources
Histone H3.3 regulates mitotic progression in mouse embryonic fibroblasts [PDF]
Biochemistry and Cell Biology, 2017 H3.3 is a histone variant that marks transcription start sites as well as telomeres and heterochromatic sites on the genome. The presence of H3.3 is thought to positively correlate with the transcriptional status of its target genes. Using a conditional genetic strategy against H3.3B, combined with short hairpin RNAs against H3.3A, we essentially ...
Ors, Aysegul +8 more
openaire +7 more sources
Promyelocytic leukemia (PML) nuclear bodies (NBs) induce latent/quiescent HSV-1 genomes chromatinization through a PML NB/Histone H3.3/H3.3 Chaperone Axis. [PDF]
PLoS Pathogens, 2018 Herpes simplex virus 1 (HSV-1) latency establishment is tightly controlled by promyelocytic leukemia (PML) nuclear bodies (NBs) (or ND10), although their exact contribution is still elusive.
Camille Cohen +11 more
doaj +1 more source
A Drosophila melanogaster H3.3 cDNA encodes a histone variant identical with the vertebrate H3.3
Gene, 1991 A cDNA encoding an H3.3 histone variant in Drosophila melanogaster predicts a protein with an amino acid (aa) sequence identical with that in vertebrates. The D. melanogaster H3.3 nucleotide (nt) sequence has diverged significantly from that of both the H3.3 gene of vertebrates and the H3.1 gene of D.
Fretzin, Scott +3 more
openaire +4 more sources