Results 31 to 40 of about 16,775 (201)

Recognizing methylated histone variant H3.3 to prevent tumors [PDF]

Cell Research, 2014
Regulatory information stored in modified histones is functionally translated by effector proteins ('readers'), which identify the histone mark to determine the specificity of the response. A recent study identifying the tumor suppressor protein ZMYND11 as an exclusive reader of methylated histone variant H3.3, throws light on the role of transcription
Swaminathan, Venkatesh, Jerry L, Workman
openaire   +2 more sources

Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone [PDF]

, 2013
It is recognized that some mutated cancer genes contribute to the development of many cancer types, whereas others are cancer type specific. For genes that are mutated in multiple cancer classes, mutations are usually similar in the different affected ...
Amary, M.F., Amary, M.F., Baumhoer Daniel, Baumhoer Daniel, Behjati Sam, Behjati Sam, Butler, A., Butler, A., Campbell Peter J., Campbell Peter J., Cooke, S.L., Cooke, S.L., Davies, H., Davies, H., Flanagan, A.M., Flanagan, A.M., Futreal, P.A., Futreal, P.A., Goodie Victoria, Goodie Victoria, Goody, V., Goody, V., Gundem, G., Gundem, G., Halai, D., Halai, D., Hamoudi Rifat Wedge David, C., Hamoudi Rifat Wedge David, C., Jundt Gernot, Jundt Gernot, Khatri, B., Khatri, B., Martin, S., Martin, S., McLaren, S., McLaren, S., Myklebost, O., Myklebost, O., Nik-Zainal, S., Nik-Zainal, S., Pillay Nischalan, Pillay Nischalan, Presneau, Nadège, Presneau, Nadège, Robinson, B., Robinson, B., Scheipl Susanne, Scheipl Susanne, Stratton, M.R., Stratton, M.R., Tarpey Patrick Campbell Peter, J., Tarpey Patrick Campbell Peter, J., Teague, J.W., Teague, J.W., Tirabosco, R., Tirabosco, R., Van Loo Peter Hassan A Bassim, Van Loo Peter Hassan A Bassim, Wedge David C., Wedge David C.   +59 more
core   +1 more source

Histone H3.3 regulates dynamic chromatin states during spermatogenesis [PDF]

Development, 2014
The histone variant H3.3 is involved in diverse biological processes, including development, transcriptional memory and transcriptional reprogramming, as well as diseases, including most notably malignant brain tumors. Recently, we developed a knockout mouse model for the H3f3b gene, one of two genes encoding H3.3.
Benjamin T K, Yuen, Kelly M, Bush, Bonnie L, Barrilleaux, Rebecca, Cotterman, Paul S, Knoepfler   +4 more
openaire   +2 more sources

The H3.3 chaperone Hira complex orchestrates oocyte developmental competence [PDF]

Development, 2020
AbstractReproductive success relies on a healthy oocyte competent for fertilisation and capable of sustaining early embryo development. By the end of oogenesis, the oocyte is characterised by a transcriptionally silenced state, but the significance of this state and how it is achieved remains poorly understood. Histone H3.3, one of the H3 variants, has
Rowena Smith, Andrej Susor, Hao Ming, Janet Tait, Marco Conti, Zongliang Jiang, Chih-Jen Lin   +6 more
openaire   +3 more sources

The Histone Variant H3.3 Is Enriched at Drosophila Amplicon Origins but Does Not Mark Them for Activation

G3: Genes, Genomes, Genetics, 2016
Eukaryotic DNA replication begins from multiple origins. The origin recognition complex (ORC) binds origin DNA and scaffolds assembly of a prereplicative complex (pre-RC), which is subsequently activated to initiate DNA replication.
Neha P. Paranjape, Brian R. Calvi
doaj   +1 more source

Auxin and epigenetic regulation of SKP2B, an F-box that represses lateral root formation [PDF]

, 2012
In plants, lateral roots originate from pericycle founder cells that are specified at regular intervals along the main root. Here, we show that Arabidopsis (Arabidopsis thaliana) SKP2B (for S-Phase Kinase-Associated Protein2B), an F-box protein ...
Beeckman, Tom, Casero, Pedro, Casimiro, Ilda, De Rybel, Bert, del Pozo, Juan C, Desvoyes, Bénédicte, Gutierrez, Crisanto, Manzano, Concepción, Otero, Sofía, Ramirez-Parra, Elena   +9 more
core   +2 more sources

The double face of the histone variant H3.3 [PDF]

Cell Research, 2011
Histone proteins wrap DNA to form nucleosome particles that compact eukaryotic genomes while still allowing access for cellular processes such as transcription, replication and DNA repair. Histones exist as different variants that have evolved crucial roles in specialized functions in addition to their fundamental role in packaging DNA.
Szenker, Emmanuelle, Ray-Gallet, Dominique, Almouzni, Geneviève   +2 more
openaire   +3 more sources

The histone H3 variant H3.3 regulates gene body DNA methylation in Arabidopsis thaliana

Genome Biology, 2017
Background Gene bodies of vertebrates and flowering plants are occupied by the histone variant H3.3 and DNA methylation. The origin and significance of these profiles remain largely unknown.
Heike Wollmann, Hume Stroud, Ramesh Yelagandula, Yoshiaki Tarutani, Danhua Jiang, Li Jing, Bhagyshree Jamge, Hidenori Takeuchi, Sarah Holec, Xin Nie, Tetsuji Kakutani, Steven E. Jacobsen, Frédéric Berger   +12 more
doaj   +1 more source

Chromatin-associated DEK proteins maintain H3K27me3 balance and coordinate developmental transitions in plants. [PDF]

New Phytol
Summary Chromatin organization and histone modifications play essential roles in regulating gene expression during development. DEK is a conserved chromatin‐associated protein implicated in DNA topology and transcriptional regulation, yet its in vivo function in plants has remained elusive.
Nakamura M, Bente H, Derkacheva M, Gentry M, Landberg K, Thelander M, Sundberg E, Hennig L, Köhler C.   +8 more
europepmc   +2 more sources

Spt5 Cooperates with Human Immunodeficiency Virus Type 1 Tat by Preventing Premature RNA Release at Terminator Sequences [PDF]

, 2002
The human immunodeficiency virus type 1 (HIV-1) Tat protein activates transcription elongation by stimulating the Tat-activated kinase (TAK/p-TEFb), a protein kinase composed of CDK9 and its cyclin partner, cyclin T1.
Bourgeois, Cyril F, Churcher, Mark J, Karn, Jonathan, Kim, Young Kyeung, West, Michelle J   +4 more
core   +3 more sources