Results 41 to 50 of about 16,775 (201)
Histone H3.3 maintains genome integrity during mammalian development [PDF]
Genes & Development, 2015 Histone H3.3 is a highly conserved histone H3 replacement variant in metazoans and has been implicated in many important biological processes, including cell differentiation and reprogramming. Germline and somatic mutations in H3.3 genomic incorporation pathway components or in H3.3 encoding genes have been associated with human congenital diseases and
Jang, Chuan-Wei +4 more
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Cell Reports, 2015 Histone H3.3 is a replication-independent histone variant, which replaces histones that are turned over throughout the entire cell cycle. H3.3 deposition at euchromatin is dependent on HIRA, whereas ATRX/Daxx deposits H3.3 at pericentric heterochromatin ...
Hsiao P.J. Voon +7 more
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Nucleic Acids Research, 2014 Abstract Histone chaperones are a diverse class of proteins that facilitate chromatin assembly. Their ability to stabilize highly abundant histone proteins in the cellular environment prevents non-specific interactions and promotes nucleosome formation, but the various mechanisms for doing so are not well understood.
DeNizio JE, Elsässer SJ, Black BE
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Histone H3.3 Mutations: A Variant Path to Cancer [PDF]
Cancer Cell, 2013 A host of cancer types exhibit aberrant histone modifications. Recently, distinct and recurrent mutations in a specific histone variant, histone H3.3, have been implicated in a high proportion of malignant pediatric brain cancers. The presence of mutant H3.3 histone disrupts epigenetic posttranslational modifications near genes involved in cancer ...
Yuen, Benjamin TK, Knoepfler, Paul S
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Histone chaperone ASF1 mediates H3.3-H4 deposition in Arabidopsis [PDF]
Nature Communications, 2022 Abstract Histone chaperones and chromatin remodelers control nucleosome dynamics, which are essential for transcription, replication, and DNA repair. The histone chaperone Anti-Silencing Factor 1 (ASF1) plays a central role in facilitating CAF-1-mediated replication-dependent H3.1 deposition and HIRA-mediated ...
Zhenhui Zhong +14 more
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DNA repair synthesis and histone deposition partner during homologous recombination
Molecular & Cellular Oncology, 2018 Chromatin remodeling is critical for the regulation of the DNA damage response. We highlight findings from our recent study showing that the deposition of the histone variant H3.3 by the alpha-thalassemia mental retardation X-linked protein (ATRX) and ...
Amira Elbakry +3 more
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Multilevel interrogation of H3.3 reveals a primordial role in transcription regulation
Epigenetics & Chromatin, 2023 Background Eukaryotic cells can rapidly adjust their transcriptional profile in response to molecular needs. Such dynamic regulation is, in part, achieved through epigenetic modifications and selective incorporation of histone variants into chromatin. H3.
Syed Nabeel-Shah +12 more
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An essential role of variant histone H3.3 for ectomesenchyme potential of the cranial neural crest.
PLoS Genetics, 2012 The neural crest (NC) is a vertebrate-specific cell population that exhibits remarkable multipotency. Although derived from the neural plate border (NPB) ectoderm, cranial NC (CNC) cells contribute not only to the peripheral nervous system but also to ...
Samuel G Cox +5 more
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Cell Reports, 2021 Summary: The ATP-dependent chromatin remodeling factor CHD1 is essential for the assembly of variant histone H3.3 into paternal chromatin during sperm chromatin remodeling in fertilized eggs.
Ines Schoberleitner +15 more
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Histone H3.3 and cancer: A potential reader connection [PDF]
Proceedings of the National Academy of Sciences, 2014 The building block of chromatin is nucleosome, which consists of 146 base pairs of DNA wrapped around a histone octamer composed of two copies of histone H2A, H2B, H3, and H4. Significantly, the somatic missense mutations of the histone H3 variant, H3.3, are associated with childhood and young-adult tumors, such as pediatric high-grade astrocytomas, as
Fei, Lan, Yang, Shi
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