Results 51 to 60 of about 16,775 (201)

Mechanisms of telomere maintenance in pediatric brain tumors: Promising targets for therapy – A narrative review

Glioma, 2020
Recent advances in genetic and molecular characterization of telomere maintenance mechanisms (TMMs) highlighted their strong relationship with cancer pathogenesis; neoplastic cells rely on two mechanisms to maintain telomere length and escape from ...
Simone Minasi, Francesca Gianno, Hiba Alzoubi, Manila Antonelli, Felice Giangaspero, Francesca Romana Buttarelli   +5 more
doaj   +1 more source

Nucleus-specific linker histones Hho1 and Mlh1 form distinct protein interactions during growth, starvation and development in Tetrahymena thermophila [PDF]

, 2019
Chromatin organization influences most aspects of gene expression regulation. The linker histone H1, along with the core histones, is a key component of eukaryotic chromatin.
Pearlman, Ronald E., Nabeel-Shah, Syed, Kanwal, Ashraf, Saettone, Alejandro, Garg, Jyoti, Derynck, Joanna, Lambert, Jean-Philippe, Fillingham, Jeffrey   +7 more
core   +1 more source

Conservation of centromeric histone 3 interaction partners in plants [PDF]

, 2020
The loading and maintenance of centromeric histone 3 (CENH3) at the centromere are critical processes ensuring appropriate kinetochore establishment and equivalent segregation of the homologous chromosomes during cell division.
Geelen, Danny, Jin, Chunlian, Keçeli, Burcu Nur, Van Damme, Daniël   +3 more
core   +1 more source

Lysine-36 ofDrosophilahistone H3.3 supports adult longevity

G3: Genes, Genomes, Genetics, 2023
AbstractAging is a multifactorial process that disturbs homeostasis, increases disease susceptibility, and ultimately results in death. Although the definitive set of molecular mechanisms responsible for aging remain to be discovered, epigenetic change over time is proving to be a promising piece of the puzzle.
Brown, John C, McMichael, Benjamin D, Vandadi, Vasudha, Matera, A Gregory, Salzler, Harmony R, Mukherjee, Aadit   +5 more
openaire   +3 more sources

UBN1/2 of HIRA complex is responsible for recognition and deposition of H3.3 at cis-regulatory elements of genes in mouse ES cells

BMC Biology, 2018
Background H3.3 is an ancient and conserved H3 variant and plays essential roles in transcriptional regulation. HIRA complex, which is composed of HIRA, UBN1 or UBN2, and Cabin1, is a H3.3 specific chaperone complex.
Chaoyang Xiong, Zengqi Wen, Juan Yu, Jun Chen, Chao-Pei Liu, Xiaodong Zhang, Ping Chen, Rui-Ming Xu, Guohong Li   +8 more
doaj   +1 more source

Application of Recombination -Induced Tag Exchange (RITE) to study histone dynamics in human cells

Epigenetics, 2020
In eukaryotes, nucleosomes form a barrier to DNA templated reactions and must be dynamically disrupted to provide access to the genome. During nucleosome (re)assembly, histones can be replaced by new histones, erasing post-translational modifications ...
Thom M. Molenaar, Marc Pagès-Gallego, Vanessa Meyn, Fred van Leeuwen   +3 more
doaj   +1 more source

Cerebral hemispheric glioblastoma with PNET-like morphology and histone H3.3 G34 mutation in younger patients: Report of three rare cases and diagnostic pitfalls

Indian Journal of Pathology and Microbiology, 2020
Recurrent mutations in H3F3A that encodes the histone 3 variant H3.3, lead to amino acid substitutions including K27M and G34R/V-which are observed in high-grade gliomas (HGGs) of children and young adults.
Yuanyuan Cheng, Weiqi Bao, Qian Wu
doaj   +1 more source

The differential mobilization of histones H3.1 and H3.3 by herpes simplex virus 1 relates histone dynamics to the assembly of viral chromatin. [PDF]

PLoS Pathogens, 2013
During lytic infections, HSV-1 genomes are assembled into unstable nucleosomes. The histones required for HSV-1 chromatin assembly, however, are in the cellular chromatin. We have shown that linker (H1) and core (H2B and H4) histones are mobilized during
Kristen L Conn, Michael J Hendzel, Luis M Schang   +2 more
doaj   +1 more source

Functional validation of a white pupae minimal gene construct in Ceratitis capitata (Diptera: Tephritidae)

Insect Science, EarlyView.
An intronless version of the white pupae (wp) gene was engineered to restore the wild type brown puparium color in white pupae phenotype mutants of the Mediterranean fruit fly, Ceratitis capitata. Functionality of the minimal gene version (mini‐wp) was verified in vivo, as one copy of mini‐wp successfully restored the wild type phenotype in homozygous ...
Lucas Henrique Figueiredo Prates, Roswitha A. Aumann, Inga Sievers, Tanja Rehling, Marc F. Schetelig   +4 more
wiley   +1 more source

Global proteomics analysis of the response to starvation in C. elegans [PDF]

, 2015
Periodic starvation of animals induces large shifts in metabolism but may also influence many other cellular systems and can lead to adaption to prolonged starvation conditions.
Alejandro Brenes Murillo, Angelo, Angus I. Lamond, Anton Gartner, Baugh, Bin Wang, Chang, Cox, Cui, Dong, Ehsan Pourkarimi, Felix, Fredens, Grun, Handke, Henderson, Hsin, Huang, Kaeberlein, Kenyon, Larance, Larance, Larance, Liang, Long, Ly, Mark Larance, McBryant, Murphy, Narbonne, Ong, Ooi, Pourkarimi, Raharjo, Rechavi, Ritorto, Robert Kent, Sabidó, Seidel, Sheaffer, Shen, Supek, Uno, Updike, Van Gilst, Van Gilst, Vellai, Wessel, Whittle, Yankovskaya, You, Yuan, Zhao   +52 more
core   +3 more sources