Results 1 to 10 of about 5,643 (237)

The H3K27M mutation alters stem cell growth, epigenetic regulation, and differentiation potential [PDF]

BMC Biology, 2022
Background Neurodevelopmental disorders increase brain tumor risk, suggesting that normal brain development may have protective properties. Mutations in epigenetic regulators are common in pediatric brain tumors, highlighting a potentially central role ...
N. Kfoury-Beaumont, R. Prakasam, S. Pondugula, J. S. Lagas, S. Matkovich, P. Gontarz, L. Yang, H. Yano, A. H. Kim, J. B. Rubin, K. L. Kroll   +10 more
doaj   +8 more sources

Small Extracellular Vesicles From Radioresistant H3K27M‐Pediatric Diffuse Midline Glioma Cells Modulate Tumor Phenotypes and Radiation Response [PDF]

Journal of Extracellular Vesicles
Pediatric diffuse midline gliomas with the Histone 3 lysine 27‐to‐methionine mutation (H3K27M‐pDMG) are aggressive brain tumors characterized by intrinsic resistance to radiation therapy, the current standard of care.
Viral D. Oza, Kenan A. Flores, Yelena Chernyavskaya, Majd A. Al‐Hamaly, Caitlyn B. Smith, Ronald C. Bruntz, Jessica S. Blackburn   +6 more
doaj   +3 more sources

Cellular reprogramming of H3K27M pediatric high-grade glioma to neuron-like state [PDF]

Acta Neuropathologica Communications
This study explores the cell fate reprogrammability of H3K27M-mutant pediatric high-grade gliomas (pHGG) using neuronal transdifferentiation as a potential targeted therapy.
Abicumaran Uthamacumaran, Cynthia Horth, Eric Bareke, Michel Gravel, Jacek Majewski   +4 more
doaj   +5 more sources

PALB2 deficiency may sensitize H3K27M-mutant pediatric HGG cells to BMN673/talazoparib [PDF]

Frontiers in Oncology
BackgroudPediatric high-grade glioma (pHGG) with the histone H3 Lys27Met substitution (H3K27M) is a devastating disease with a high mortality rate in children and adolescents (from birth to 19 years of age).
Xiaowen Guan, Xinke Xu, Xiaolan Mo, Houliang Deng   +3 more
doaj   +2 more sources

A deep learning-based automatic segmentation model for diffuse midline glioma with H3K27M alteration [PDF]

Frontiers in Oncology
BackgroundDiffuse midline glioma (DMG) is a fatal tumor that emerges in the brainstem and thalamus. Compared with microsurgery and chemotherapy, radiotherapy is currently regarded as a safer and more effective treatment option.
Yong Deng, Tengyun Chen, Yuekang Zhang, Bowen Huang   +3 more
doaj   +2 more sources

MGMT Expression Contributes to Temozolomide Resistance in H3K27M-Mutant Diffuse Midline Gliomas [PDF]

, 2020
新潟大学博士(医学)Diffuse midline gliomas (DMGs) show resistance to many chemotherapeutic agents including temozolomide (TMZ). Histone gene mutations in DMGs trigger epigenetic changes including DNA hypomethylation, one of which is a frequent lack ofO6-methyl ...
177999, Abe, Hideaki
core   +2 more sources

Navitoclax acts synergistically with irradiation to induce apoptosis in preclinical models of H3K27M-altered diffuse midline glioma [PDF]

Scientific Reports
Diffuse midline gliomas (DMGs) with histone H3K27M mutations represent a devastating paediatric brain cancer characterised by abysmal prognosis and limited treatment options.
Ashley Vardon, Scott Haston, Hiba Hamdi, Grace Cooksley, Romain Guiho, Diana Carvalho, Rebecca Carter, Jessica Katherine Rowena Boult, Daniel Gharai, Ielyaas Cloete, James Grey, John Apps, Daohong Zhou, Guangrong Zheng, Ramón Martínez-Máñez, Mark Francis Lythgoe, Laura Kate Donovan, Angel Montero Carcaboso, Owen Williams, Ying Hong, Paula Alexandre, Jesus Gil, Jamie Adam Dean, David Michod, Chris Jones, Darren Hargrave, Juan-Pedro Martinez-Barbera   +26 more
doaj   +2 more sources

Co-detection of mutations and methylations in cerebrospinal fluid ctDNA for minimally-invasive diagnosis of brainstem glioma [PDF]

Journal of Experimental & Clinical Cancer Research
Background Genetic and epigenetic profiles are critical in managing brainstem gliomas (BSG), whose heterogeneity is far beyond the realm of the Diffuse midline glioma, H3K27 altered.
Tian Li, Huan Wang, Yujin Wang, Yiying Mai, Pei Wang, Mingxin Zhang, Zhuang Jiang, Luyang Xie, Hang Zhou, Yi Wang, Xiaoou Li, Dan Xiao, Jingyao Geng, Wenhao Wu, Peng Zhang, Liang Wang, Zhen Wu, Junting Zhang, Dandan Cao, Changchun Pan, Liwei Zhang   +20 more
doaj   +2 more sources

H3F3B p.K27I-mutant diffuse midline glioma is a distinct subtype of H3K27-altered diffuse midline glioma [PDF]

Acta Neuropathologica Communications
H3K27-altered diffuse midline glioma (DMG) is a fatal disease, including four subtypes H3.3-mutant, H3.1/H3.2-mutant, H3-wildtype with EZHIP overexpression, and EGFR-mutant.
Lei Cheng, Min Zhou, Tao Luo, Rongfang Dong, Ni Chen, Xinyong Cai, Xingwen Wang, Hao Wu, Zan Chen, Zuowei Wang, Xueling Qi, Dehong Lu, Lianghong Teng, Fengzeng Jian, Leiming Wang   +14 more
doaj   +2 more sources

Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma [PDF]

Nature Communications, 2016
Diffuse Intrinsic Pontine Gliomas are diagnosed by sampling a small portion of the tumour. Here, using multiple samples from tumours, the authors analyse the spatial and temporal distribution of driver mutations revealing that H3K27M mutations arise ...
Hamid Nikbakht, Eshini Panditharatna, Leonie G. Mikael, Rui Li, Tenzin Gayden, Matthew Osmond, Cheng-Ying Ho, Madhuri Kambhampati, Eugene I. Hwang, Damien Faury, Alan Siu, Simon Papillon-Cavanagh, Denise Bechet, Keith L. Ligon, Benjamin Ellezam, Wendy J. Ingram, Caedyn Stinson, Andrew S. Moore, Katherine E. Warren, Jason Karamchandani, Roger J. Packer, Nada Jabado, Jacek Majewski, Javad Nazarian   +23 more
doaj   +4 more sources