Results 91 to 100 of about 5,643 (237)
Intraoperative Consultations of Central Nervous System Tumors: A Review for Practicing Pathologists and Testing of an Algorithmic Approach. [PDF]
, 2019 Intraoperative consultations or frozen sections for central nervous system (CNS) tumors present a significant challenge for surgical pathologists because of their relative rarity and diversity.
Ding, Cristine +4 more
core
What Epigenetics Teaches Us About Neuron–Glioma Interactions
BioEssays, Volume 47, Issue 9, September 2025.Neuron–glioma interactions through the epigenetic lens. Rewiring of epigenetic mechanisms, including alterations in the enhancer landscape and 3D chromatin organization, allows glioma cells to sense and respond to neural signals. Targeting the epigenetic machinery that facilitates this neuron–glioma crosstalk provides a strategy to disrupt the neural ...
Chaitali Chakraborty +2 more
wiley +1 more source
K27M-mutant histone-3 as a novel target for glioma immunotherapy
OncoImmunology, 2017 Mutation-specific vaccines have become increasingly important in glioma immunotherapy; however, shared neoepitopes are rare. For diffuse gliomas, a driver mutation in the gene for isocitrate dehydrogenase type-1 has been shown to produce an immunogenic ...
Katharina Ochs +10 more
doaj +1 more source
Oncohistone-sculpted epigenetic mechanisms in pediatric brain cancer [PDF]
Chromatin dynamics, involving reversible changes in chromatin structure, shape key cellular processes and genomic integrity during development and proliferation, with disruptions leading to cancer.
Pandey, Deo Prakash, Somyajit, Kumar
core +1 more source
Pediatric Discovery, Volume 3, Issue 3, September 2025.The graphical abstract will illustrate the key findings of our study, highlighting the OPC‐like subpopulations and their role in driving tumorigenic lineage transitions in pediatric high‐grade gliomas. ABSTRACT Pediatric high‐grade gliomas (pHGG) were first defined as a distinct entity in the 2021 fifth edition of the WHO classification of tumors of ...
Tian Tian, Chong Huang, Lusheng Li
wiley +1 more source
Epigenetic activation of a RAS/MYC axis in H3.3K27M-driven cancer
Nature Communications, 2020 Histone H3 at lysine 27 (H3K27M) is often mutated in cancer but its role in tumour initiation is unclear. Here, the authors generated a transgenic model expressing H3.3K27M from the Fabp7 gene promoter, demonstrating that H3.3K27M can initiate diverse ...
Sanja Pajovic +15 more
doaj +1 more source
HGG-03. PEDIATRIC BITHALAMIC GLIOMA H3K27M NEGATIVE AND EGFR POSITIVE: A DISTINCT ENTITY WITH POTENTIAL SENSIBILITY TO EGFR INHIBITORS [PDF]
, 2022 Marta Cortes Hernandez +6 more
openalex +1 more source
Cancer Innovation, Volume 4, Issue 4, August 2025.Glioblastoma (GBM) remains a highly malignant brain tumor with limited treatment efficacy, driving the need for innovative cellular immune theranostic strategies that integrate diagnostic and therapeutic approaches. Recent advances in cellular immunotherapy for GBM include chimeric antigen receptor (CAR)‐T/NK cells, macrophage‐based therapies ...
Ying Gong +14 more
wiley +1 more source
How I Approach Ethical Considerations for Pediatric Phase I CAR T‐Cell Trials
Pediatric Blood &Cancer, Volume 72, Issue 8, August 2025.ABSTRACT Phase I trials of chimeric antigen receptor (CAR) T cells have shown remarkable promise in pediatric B‐cell malignancies. Such outcomes have shifted expectations for other phase I CAR T‐cell trials to have high response rates. The juxtaposition of high expectations, uncertain outcomes, and potential for life‐threatening toxicities raises ...
Sarah W. Peters +6 more
wiley +1 more source
Evaluation of a novel antibody to define histone 3.3 G34R mutant brain tumours [PDF]
, 2017 Missense somatic mutations affecting histone H3.1 and H3.3 proteins are now accepted as the hallmark of paediatric diffuse intrinsic pontine gliomas (DIPG), non-brain stem paediatric high grade gliomas (pHGG) as well as a subset of adult glioblastoma ...
D Bechet +12 more
core +2 more sources