Results 101 to 110 of about 5,643 (237)

The immune response behind peptide vaccination in diffuse midline glioma

Molecular Oncology
A first‐in‐human trial demonstrated that a vaccine targeting the histone mutation H3K27M can induce an immune response, in a mutation‐specific manner, in patients with diffuse midline glioma.
Craig A. Vincent, Silvia Remeseiro
doaj   +1 more source

Intraoperative Fast Adaptive Focus Tracking Robotic OCT Enables Real‐Time Tumor Grading and Large‐Area Microvascular Imaging in Human Spinal Cord Surgery

Advanced Science, Volume 12, Issue 27, July 17, 2025.
The fast adaptive focus tracking robotic optical coherence tomography (FACT‐ROCT) offers real‐time, high‐resolution imaging of spinal cord tumors during surgery. By reducing motion artifacts with robotics and adaptive focal tracking, it accurately differentiates tumor grades using a novel attenuation coefficient marker and reveals critical ...
Bin He, Yuzhe Ying, Yejiong Shi, Zhe Meng, Zichen Yin, Zhengyu Chen, Zhangwei Hu, Ruizhi Xue, Linkai Jing, Yang Lu, Zhenxing Sun, Weitao Man, Youtu Wu, Dan Lei, Ning Zhang, Guihuai Wang, Ping Xue   +16 more
wiley   +1 more source

MRI‐Based Score to Recognize Thalamic Glioma Grade in Children: Morphology, Diffusion, and Arterial‐Spin‐Labeling Perfusion

Pediatric Blood &Cancer, Volume 72, Issue 7, July 2025.
ABSTRACT Purpose Thalamic gliomas are found predominantly in children and can be classified into two main types with different prognoses and management: diffuse midline glioma (DMG) H3K27‐altered and low‐grade glioma (LGG). Our aim was to find imaging features distinguishing these tumors and to develop a diagnostic score.
Alexis Plasse, Raphael Levy, Arnault Tauziède‐Espariat, Thibault Agripnidis, Jean‐François Hak, Charles‐Joris Roux, Thomas Samoyeau, Alexis Ollitrault, Kevin Beccaria, Lelio Guida, Thomas Blauwblomme, Jacques Grill, Christelle Dufour, Léa Guerrini‐Rousseau, Franck Bourdeaut, François Doz, Pascale Varlet, Nathalie Boddaert, Volodia Dangouloff‐Ros   +18 more
wiley   +1 more source

EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas

Nature Medicine, 2017
Diffuse intrinsic pontine glioma (DIPG) is an aggressive brain tumor that is located in the pons and primarily affects children. Nearly 80% of DIPGs harbor mutations in histone H3 genes, wherein lysine 27 is substituted with methionine (H3K27M). H3K27M has been shown to inhibit polycomb repressive complex 2 (PRC2), a multiprotein complex responsible ...
Faizaan Mohammad, Simon Weissmann, Benjamin Leblanc, Deo P Pandey, Jonas W Højfeldt, Itys Comet, Chunqin Zheng, Jens Vilstrup Johansen, Nicolas Rapin, Bo T Porse, Andrey Tvardovskiy, Ole N Jensen, Nagore G Olaciregui, Cinzia Lavarino, Mariona Suñol, Carmen de Torres, Jaume Mora, Angel M Carcaboso, Kristian Helin   +18 more
openaire   +6 more sources

Molecular profile of adult primary leptomeningeal gliomatosis aligns with glioblastoma, IDH‐wildtype

Brain Pathology, Volume 35, Issue 4, July 2025.
The molecular profile of adult primary leptomeningeal gliomatosis closely aligned with that of adult‐type glioblastoma, IDH‐wildtype, CNS WHO grade 4. Abstract Adult primary leptomeningeal gliomatosis (PLG) is a rare, rapidly progressive and fatal disease characterized by prominent leptomeningeal infiltration by a glial tumor without an identifiable ...
Yi Zhu, Darin D. Carabenciov, Derek R. Johnson, Jorge A. Trejo‐Lopez, Aivi T. Nguyen, Aditya Raghunathan, Giuseppe Lanzino, Cristiane M. Ida, Cinthya J. Zepeda‐Mendoza, Surendra Dasari, Emilie Russler‐Germain, Sonika Dahiya, Martha Quezado, Kenneth Aldape, Caterina Giannini   +14 more
wiley   +1 more source

Resource availability for CNS tumor diagnostics in the Asian Oceanian region: A survey by the Asian Oceanian Society of Neuropathology committee for Adapting Diagnostic Approaches for Practical Taxonomy in Resource‐Restrained Regions (AOSNP‐ADAPTR)

Brain Pathology, Volume 35, Issue 4, July 2025.
Asian Oceanian Society of Neuropathology‐Adapting Diagnostic Approaches for Practical Taxonomy in Resource‐Restrained Regions survey provides an overview of in‐house/ local and outsourcing resources in Asian Oceanian region for brain tumor diagnostics according to World Health Organization classification of Central Nervous System tumors.
Chitra Sarkar, Shilpa Rao, Vani Santosh, Maysa Al‐Hussaini, Sung Hye Park, Tarik Tihan, Michael E. Buckland, Ho‐Keung Ng, Takashi Komori   +8 more
wiley   +1 more source

Single-cell RNA sequencing of anaplastic ependymoma and H3K27M-mutant diffuse midline glioma

BMC Neurology
Background Anaplastic ependymoma and H3K27M-mutant diffuse midline glioma are two common subtypes of brain tumors with poor long-term prognosis. The present study analyzed and compared the differences in cell types between two tumors by single-cell RNA ...
Dongdong Zang, Zilong Dong, Yuecheng Liu, Qian Chen   +3 more
doaj   +1 more source

Personalized Treatment of H3K27M-Mutant Pediatric Diffuse Gliomas Provides Improved Therapeutic Opportunities

Frontiers in Oncology, 2020
Diffuse gliomas with K27M histone mutations (H3K27M glioma) are generally characterized by a fatal prognosis, particularly affecting the pediatric population.
Johannes Gojo, Johannes Gojo, Zdenek Pavelka, Danica Zapletalova, Danica Zapletalova, Maria T. Schmook, Lisa Mayr, Lisa Mayr, Sibylle Madlener, Sibylle Madlener, Michal Kyr, Michal Kyr, Klara Vejmelkova, Klara Vejmelkova, Martin Smrcka, Thomas Czech, Thomas Czech, Christian Dorfer, Christian Dorfer, Jarmila Skotakova, Amedeo A. Azizi, Amedeo A. Azizi, Monika Chocholous, Monika Chocholous, Dominik Reisinger, Dominik Reisinger, David Lastovicka, Dalibor Valik, Christine Haberler, Andreas Peyrl, Andreas Peyrl, Hana Noskova, Karol Pál, Marta Jezova, Renata Veselska, Sarka Kozakova, Ondrej Slaby, Ondrej Slaby, Irene Slavc, Irene Slavc, Jaroslav Sterba, Jaroslav Sterba, Jaroslav Sterba   +42 more
doaj   +1 more source

P06.01 Pediatric non-pontine diffuse midline glioma H3K27M mutant: a monoinstitutional experience [PDF]

, 2021
Elisabetta Schiavello, Veronica Biassoni, Loris De Cecco, Emilia Pecori, Sylvie Di Filippo, Lorenza Gandola, Maura Massimino   +6 more
openalex   +1 more source

Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2

Nature Communications, 2016
Polycomb repressive complex 2 (PRC2) silences gene expression through trimethylation of K27 of histone H3 (H3K27Me). Here, the authors report the structure of the human PRC2 complex bound to the oncogenic H3K27M mutant, and suggest a mechanism for its ...
Neil Justin, Ying Zhang, Cataldo Tarricone, Stephen R. Martin, Shuyang Chen, Elizabeth Underwood, Valeria De Marco, Lesley F. Haire, Philip A. Walker, Danny Reinberg, Jon R. Wilson, Steven J. Gamblin   +11 more
doaj   +1 more source