Results 111 to 120 of about 5,643 (237)

A comprehensive genomic study of 390 H3F3A‑mutant pediatric and adult difuse high‑grade gliomas, CNS WHO grade 4 [PDF]

Malignant brain tumors, known as H3K27-altered diffuse midline glioma (DMG) and H3G34-mutant diffuse hemispheric glioma (DHG), can affect individuals of all ages and are classified as CNS WHO grade 4.
Brastianos, Priscilla K., Cahill, Daniel P., Filbin, Mariella G., Juratli, Tareq A., Santagata, Sandro, Wakimoto, Hiroaki, Williams, Erik A., Zolal, Amir   +7 more
core   +2 more sources

DIPG-64. UNRAVELING H3K27M INTERACTIONS IN DIFFUSE MIDLINE GLIOMA

Neuro-Oncology
Abstract BACKGROUND Diffuse midline glioma (DMG) harboring the histone H3 K27M mutation, also known as diffuse intrinsic pontine glioma when it occurs in the pons, is a uniformly fatal pediatric brain tumor. We sought to better understand protein-protein interactions of the mutant histone in DMG.
Liapodimitri, Athanasia, Lunsford, Kayleigh, Tetens, Ashley R, Craig-Schwartz, Jordyn, Vesuna, Farhad, Raman, Venu, Koldobskiy, Michael A   +6 more
openaire   +1 more source

A pineal mass in a 39‐year‐old woman

Brain Pathology, Volume 35, Issue 5, September 2025.
Charlotte Paoli, Thibault Fabas, Lydiane Mondot, Catherine Godfraind, Bérengère Dadone‐Montaudié, Fanny Burel‐Vandenbos   +5 more
wiley   +1 more source

H3.1K27M-induced misregulation of the TONSOKU-H3.1 pathway causes genomic instability

Nature Communications
The oncomutation lysine 27-to-methionine in histone H3 (H3K27M) is frequently identified in tumors of patients with diffuse midline glioma-H3K27 altered (DMG-H3K27a).
Wenxin Yuan, Yi-Chun Huang, Chantal LeBlanc, Axel Poulet, Francisca N. De Luna Vitorino, Devisree Valsakumar, Renee Dean, Benjamin A. Garcia, Josien C. van Wolfswinkel, Philipp Voigt, Yannick Jacob   +10 more
doaj   +1 more source

Emerging roles of cancer-associated histone mutations in genomic instabilities

Frontiers in Cell and Developmental Biology
Epigenetic mechanisms often fuel the quick evolution of cancer cells from normal cells. Mutations or aberrant expressions in the enzymes of DNA methylation, histone post-translational modifications, and chromatin remodellers have been extensively ...
Priyanka Yadav, Ronit Jain, Rajesh Kumar Yadav   +2 more
doaj   +1 more source

Treatment Strategies in Diffuse Midline Gliomas With the H3K27M Mutation: The Role of Convection-Enhanced Delivery in Overcoming Anatomic Challenges [PDF]

, 2019
Benjamin Himes, Liang Zhang, David J. Daniels   +2 more
openalex   +1 more source

Table S9 from Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways

, 2023
Sriram Venneti, Abed Rahman Kawakibi, Sunjong Ji, Sebastian M. Waszak, Stefan R. Sweha, Mateus Mota, Matthew Pun, Akash Deogharkar, Chan Chung, Rohinton S. Tarapore, Samuel Ramage, Andrew Chi, Patrick Y. Wen, Isabel Arrillaga‐Romany, Tracy T. Batchelor, Nicholas Butowski, Ashley Sumrall, Nicole Shonka, Rebecca A. Harrison, John de Groot, Minesh P. Mehta, Matthew D. Hall, Doured Daghistani, Timothy F. Cloughesy, Benjamin M. Ellingson, Kévin Beccaria, Pascale Varlet, Michelle M. Kim, Yoshie Umemura, Hugh Garton, Andrea Franson, Jonathan Schwartz, Rajan Jain, Maureen Kachman, Heidi Baum, Charles Burant, Sophie L. Mottl, Rodrigo T. Cartaxo, Vishal John, Dana Messinger, Tingting Qin, Erik Peterson, Peter Sajjakulnukit, Karthik Ravi, Alyssa Waugh, Dustin Walling, Yujie Ding, Ziyun Xia, Anna Schwendeman, Debra Hawes, Fusheng Yang, Alexander R. Judkins, Daniel Wahl, Costas A. Lyssiotis, Daniel de la Nava, Marta M. Alonso, Augustine Eze, Jasper Spitzer, Susanne V. Schmidt, Ryan J. Duchatel, Matthew D. Dun, Jason E. Cain, Li Jiang, Sylwia A. Stopka, Gerard Baquer, Michael S. Regan, Mariella G. Filbin, Nathalie Y.R. Agar, Lili Zhao, Chandan Kumar‐Sinha, Rajen Mody, Arul M. Chinnaiyan, Ryo Kurokawa, Drew Pratt, Viveka Nand Yadav, Jacques Grill, Cassie Kline, Sabine Mueller, Adam Resnick, Javad Nazarian, Joshua E. Allen, Yazmín Odia, Sharon L. Gardner, Carl Koschmann   +83 more
openalex   +1 more source

EZHIP's role in diffuse midline glioma: echoes of oncohistones? [PDF]

The enhancer of zeste inhibitory protein (EZHIP) is typically expressed during germ cell development and has been classified as a cancer-testis antigen (CTA) in various cancers.
Cassim, A, Dun, MD, Gallego-Ortega, D, Valdes-Mora, F   +3 more
core   +1 more source

HGG-19. CLINICAL RESPONSE TO THE PDGFRA/KIT INHIBITOR AVAPRITINIB IN PEDIATRIC AND YOUNG ADULT HIGH-GRADE GLIOMA PATIENTS WITH H3K27M OR PDGFRA GENOMIC ALTERATIONS [PDF]

, 2023
Maria Trissal, Lisa Mayr, Kallen Schwark, Jenna LaBelle, Seongbae Kong, Julia Furtner, Liesa Weiler‐Wichtl, Jeffrey Supko, Jacob S Rozowsky, Olivia A. Hack, Andrew Groves, Joana G. Marques, Ulrike Leiss, Verena Rosenmayr, Frank Dubois, Noah F. Greenwald, Sibylle Madlener, Armin Sebastian Guntner, Hana Pálová, Natalia Stepien, Daniela Lötsch-Gojo, Christian Dorfer, Karen Dieckmann, Andreas Peyrl, Amadeo A Azizi, Alicia Baumgartner, Ondřej Slabý, Petra Pokorná, Pratiti Bandopadhayay, Rameen Beroukhim, Keith L. Ligon, Christof M. Kramm, Annika Bronsema, Simon Bailey, Ana Guerreiro Stücklin, Sabine Mueller, David Jones, Natalie Jäger, Leonhard Müllauer, Christine Haberler, Chandan Kumar‐Sinha, Arul M. Chinnaiyan, Rajen Mody, Jaroslav Štěrba, Mary Skrypek, Nina Martinez, Daniel C. Bowers, Carl Koschmann Koschmann, Johannes Gojo, Mariella G. Filbin   +49 more
openalex   +1 more source

H3K27M-mutant, hemispheric diffuse glioma in an adult patient with prolonged survival

, 2021
Noel Chia, Andrea L.A. Wong, Kejia Teo, Ai Peng Tan, Balamurugan Vellayappan, Tseng Tsai Yeo, Shoo Yi Oh, Char Loo Tan   +7 more
openalex   +1 more source