Results 121 to 130 of about 5,643 (237)

DIPG-60. Avapritinib for targeting PDGFRA in H3K27M – mutated diffuse midline glioma [PDF]

, 2022
Lisa Mayr, Sibylle Madlener, Liesa Weiler‐Wichtl, Verena Rosenmayr, Julia Furtner-Srajer, Armin Sebastian Guntner, Natalia Stepien, Alicia-Christina Baumgartner, Christian Dorfer, Christine Haberler, Leonhard Müllauer, Hana Pálová, Petra Pokorná, Jaroslav Štěrba, Karin Dieckmann, Amedeo A. Azizi, Andreas Peyrl, Sean Kim, Antony Hsieh, Saša Dimitrijević, Johannes Gojo   +20 more
openalex   +1 more source

Intravenous and intracranial GD2-CAR T cells for H3K27M+ diffuse midline gliomas

Nature
Abstract H3K27M-mutant diffuse midline gliomas (DMGs) express high levels of the disialoganglioside GD2 (ref. 1). Chimeric antigen receptor-modified T cells targeting GD2 (GD2-CART) eradicated DMGs in preclinical models1. Arm A of Phase I trial no. NCT04196413 (ref.
Michelle Monje, Jasia Mahdi, Robbie Majzner, Kristen W. Yeom, Liora M. Schultz, Rebecca M. Richards, Valentin Barsan, Kun-Wei Song, Jen Kamens, Christina Baggott, Michael Kunicki, Skyler P. Rietberg, Alexandria Sung Lim, Agnes Reschke, Sharon Mavroukakis, Emily Egeler, Jennifer Moon, Shabnum Patel, Harshini Chinnasamy, Courtney Erickson, Ashley Jacobs, Allison K. Duh, Ramya Tunuguntla, Dorota Danuta Klysz, Carley Fowler, Sean Green, Barbara Beebe, Casey Carr, Michelle Fujimoto, Annie Kathleen Brown, Ann-Louise G. Petersen, Catherine McIntyre, Aman Siddiqui, Nadia Lepori-Bui, Katlin Villar, Kymhuynh Pham, Rachel Bove, Eric Musa, Warren D. Reynolds, Adam Kuo, Snehit Prabhu, Lindsey Rasmussen, Timothy T. Cornell, Sonia Partap, Paul G. Fisher, Cynthia J. Campen, Gerald Grant, Laura Prolo, Xiaobu Ye, Bita Sahaf, Kara L. Davis, Steven A. Feldman, Sneha Ramakrishna, Crystal Mackall   +53 more
openaire   +2 more sources

Rational combination platform trial design for children and young adults with diffuse midline glioma: A report from PNOC [PDF]

Background: Diffuse midline glioma (DMG) is a devastating pediatric brain tumor unresponsive to hundreds of clinical trials. Approximately 80% of DMGs harbor H3K27M oncohistones, which reprogram the epigenome to increase the metabolic profile of the ...
Franson, Andrea T, Kline, Cassie, Koschmann, Carl, Molinaro, Annette M, Mueller, Sabine, Nazarian, Javad, Plasschaert, Sabine L A, Prados, Michael, van der Lugt, Jasper, Waszak, Sebastian M   +9 more
core   +1 more source

EZHIP boosts neuronal-like synaptic gene programs and depresses polyamine metabolism

Acta Neuropathologica Communications
It is currently understood that the characteristic loss of the repressive histone mark H3K27me3 in PFA ependymoma and diffuse midline glioma (DMG) are caused by complementary mechanisms mediated by EZHIP and the oncohistone H3K27M, respectively.
Elham Hasheminasabgorji, Huey-Miin Chen, Taylor A. Gatesman, Subhi Talal Younes, Gabrielle A. Nobles, Farhang Jaryani, Heather Mao, Kwanha Yu, Benjamin Deneen, Wee Yong, Michael D. Taylor, Sameer Agnihotri, Marco Gallo   +12 more
doaj   +1 more source

PATH-35. FREQUENCY AND CHARACTERISTICS OF H3K27M-MUTATION IN ADULTS WITH RADIOGRAPHICALLY-DETERMINED MIDLINE GLIOMAS [PDF]

, 2018
Karisa C. Schreck, Surabhi Ranjan, Nebojša Skorupan, Heather M. Ames, Matthias Holdhoff   +4 more
openalex   +1 more source

FOXR2 Targets LHX6+/DLX+ Neural Lineages to Drive Central Nervous System Neuroblastoma [PDF]

Central nervous system neuroblastoma with forkhead box R2 (FOXR2) activation (NB-FOXR2) is a high-grade tumor of the brain hemispheres and a newly identified molecular entity.
Bandopadhayay, Pratiti, Chandarana, Bhavyaa, De Cola, Antonella, Ellezam, Benjamin, Faury, Damien, Hébert, Steven, Jabado, Nada, Jessa, Selin, Jones, David T W, Kleinman, Claudia L, Korshunov, Andrey, McNicholas, Michael, Pathania, Manav, Phoenix, Timothy N, Ptack, Adam, Taylor, Michael D, Tsai, Jessica W   +16 more
core   +2 more sources

Characteristics of H3K27M-mutant diffuse gliomas with a non-midline location

Journal of Neuro-Oncology
Abstract Purpose: Diffuse midline gliomas (DMG) with H3K27 alterations (H3K27M-DMG) are a highly aggressive form of brain cancer. In rare cases, H3K27 mutations have been observed in diffuse non-midline gliomas (DNMG). It is currently unclear how these tumors should be classified.
Souhir, Guidara, Antoine, Seyve, Delphine, Poncet, Camille, Leonce, Pierre-Paul, Bringuier, Anne, McLeer, Dominik, Sturm, Stéphanie, Cartalat, Thiebaud, Picart, Anthony, Ferrari, Jürgen, Hench, Stephan, Frank, David, Meyronet, François, Ducray, Marc, Barritault   +14 more
openaire   +2 more sources

An ERK5-PFKFB3 axis regulates glycolysis and represents a therapeutic vulnerability in pediatric diffuse midline glioma [PDF]

Metabolic reprogramming in pediatric diffuse midline glioma is driven by gene expression changes induced by the hallmark histone mutation H3K27M, which results in aberrantly permissive activation of oncogenic signaling pathways.
Agrawal, Nishant, Barber, Callie S, Biagi-Junior, Carlos A O, Casillo, Stephanie M, Chang, Yue-Fang, Cheney, Allison, Chilukuri, Akanksha, Cruz, Andrea F, David Premkumar, Daniel R, et al, et al, Felker, James, Gatesman, Taylor A, Golbourn, Brian J, Halbert, Matthew E, Halligan, Katharine, Jane, Esther P, Johnson, Brenden J, Koncar, Robert F, Land, Clinton Van't, Lieberman, Frank S, Mansi, Neveen M, MichaelRaj, Antony, Michel, Joshua J, Mullett, Steven J, Myers, Max I, Nazarian, Javad, Perez, Jennifer L, Plute, Tritan J, Shiva, Sruti, Stanton, Ann-Catherine J, Varadharajan, Srinidhi, Vaske, Olena M   +32 more
core   +1 more source

Elucidating intratumour heterogeneity through investigation of clonal, transcriptomic, and proteomic features across models of triple negative breast cancer and diffuse intrinsic pontine glioma [PDF]

Intratumour heterogeneity defines the diversity found within those malignant populations that take up residence within our bodies as cancer. These cellular societies comprise actors of diverse talents, from those suited to rapid proliferation, to drug ...

core   +2 more sources

H2A.Z histone variants facilitate HDACi-dependent removal of H3.3K27M mutant protein in pediatric high-grade glioma cells [PDF]

Diffuse intrinsic pontine gliomas (DIPGs) are deadly pediatric brain tumors, non-resectable due to brainstem localization and diffusive growth.
et al.,, Garcia, Benjamin A, Leszczynska, Katarzyna B, Vitorino, Francisca N L   +3 more
core   +2 more sources