Results 131 to 140 of about 5,643 (237)
Therapeutic targeting of differentiation-state dependent metabolic vulnerabilities in diffuse midline glioma
Nature CommunicationsH3K27M diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPG), exhibit cellular heterogeneity comprising less-differentiated oligodendrocyte precursors (OPC)-like stem cells and more differentiated astrocyte (AC)-like cells ...Nneka E. Mbah, Amy L. Myers, Peter Sajjakulnukit, Chan Chung, Joyce K. Thompson, Hanna S. Hong, Heather Giza, Derek Dang, Zeribe C. Nwosu, Mengrou Shan, Stefan R. Sweha, Daniella D. Maydan, Brandon Chen, Li Zhang, Brian Magnuson, Zirui Zhu, Megan Radyk, Brooke Lavoie, Viveka Nand Yadav, Imhoi Koo, Andrew D. Patterson, Daniel R. Wahl, Luigi Franchi, Sameer Agnihotri, Carl J. Koschmann, Sriram Venneti, Costas A. Lyssiotis +26 moredoaj +1 more sourceEffective targeting of PDGFRA-altered high-grade glioma with avapritinib [PDF]
\ua9 2025 The Authors. PDGFRA is crucial to tumorigenesis and frequently genomically altered in high-grade glioma (HGG). In a comprehensive dataset of pediatric HGG (n = 261), we detect PDGFRA mutations and/or amplifications in 15% of cases, suggesting ...Adam T, Azizi AA, Bailey S, Bandopadhayay P, Baumgartner A, Beck A, Berger W, Beroukhim R, Bowers DC, Bronsema A, Bruckner K, Cameron A, Castellani S, Chapman O, Chavez L, Chinnaiyan A, Clark LM, Cruzeiro GAV, de Biagi-Junior CAO, Dieckmann K, Dorfer C, Dubois F, Dutta A, Eder SK, Filbin MG, Furtner J, Gojo J, Greenwald NF, Groves A, Guntner AS, Haase RD, Haberler C, Hack O, Jager N, Jones C, Jones DTW, Kenkre R, Kong S, Koschmann C, Kramm C, Kumar-Sinha C, Labelle J, Lammerer A, Leiss U, Ligon K, Lo Cascio C, Lotsch-Gojo D, Madlener S, Marques JG, Martinez N, Mayr L, Miclea M, Mody R, Mueller S, Mullauer L, Nascimento A, Neradil J, Neyazi S, Nguyen CM, Nguyen Q-D, Palova H, Panditharatna E, Patel T, Peyrl A, Pokorna P, Rosenmayr V, Rozowsky JS, Schwark K, Senfter D, Skrypek M, Slaby O, Sridhar S, Stepien N, Sterba J, Stucklin AG, Supko J, Tabatabai K, Trissal M, Wadden J, Wakimoto H, Wang J, Wang S, Weiler-Wichtl L +82 morecore DIPG-15. Major tumor regressions in H3K27M-mutated diffuse midline glioma (DMG) following sequential intravenous (IV) and intracerebroventricular (ICV) delivery of GD2-CAR T-cells [PDF]
, 2022 Michelle Monje, Robbie G. Majzner, Jasia Mahdi, Sneha Ramakrishna, Shabnum Patel, Harshini Chinnasamy, Kristen W. Yeom, Liora M. Schultz, Valentin Barsan, Rebecca M. Richards, Cynthia Campen, Agnes Reschke, Angus Toland, Christina Baggott, Sharon Mavroukakis, Emily Egeler, Jennifer Moon, Ashley Jacobs, Karen Yamabe-Kwong, Lindsey Rasmussen, Esther H. Nie, Sean Green, Michael Kunicki, Michele Fujimoto, Zachary Ehlinger, Warren D. Reynolds, Snehit Prabhu, Katherine E. Warren, Tim Cornell, Sonia Partap, Paul A. Fisher, Gerald A. Grant, Hannes Vogel, Bita Sahaf, Kara L. Davis, Steven A. Feldman, Crystal L. Mackall +36 moreopenalex +1 more sourceCorrelation of multimodal 18F-DOPA PET and conventional MRI with treatment response and survival in children with diffuse intrinsic pontine gliomas [PDF]
, 2020 Barra, S., Bottoni, G., Cistaro, A., Garibotto, F., Garre, M. L., Giannelli, F., Massimino, M., Milanaccio, C., Morana, G., Piatelli, G., Piccardo, A., Puntoni, M., Rossi, A., Severino, M., Tortora, D., Verrico, A. +15 morecore +1 more sourceTable S1 from Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways
, 2023 Sriram Venneti, Abed Rahman Kawakibi, Sunjong Ji, Sebastian M. Waszak, Stefan R. Sweha, Mateus Mota, Matthew Pun, Akash Deogharkar, Chan Chung, Rohinton S. Tarapore, Samuel Ramage, Andrew Chi, Patrick Y. Wen, Isabel Arrillaga‐Romany, Tracy T. Batchelor, Nicholas Butowski, Ashley Sumrall, Nicole Shonka, Rebecca A. Harrison, John de Groot, Minesh P. Mehta, Matthew D. Hall, Doured Daghistani, Timothy F. Cloughesy, Benjamin M. Ellingson, Kévin Beccaria, Pascale Varlet, Michelle M. Kim, Yoshie Umemura, Hugh Garton, Andrea Franson, Jonathan Schwartz, Rajan Jain, Maureen Kachman, Heidi Baum, Charles Burant, Sophie L. Mottl, Rodrigo T. Cartaxo, Vishal John, Dana Messinger, Tingting Qin, Erik Peterson, Peter Sajjakulnukit, Karthik Ravi, Alyssa Waugh, Dustin Walling, Yujie Ding, Ziyun Xia, Anna Schwendeman, Debra Hawes, Fusheng Yang, Alexander R. Judkins, Daniel Wahl, Costas A. Lyssiotis, Daniel de la Nava, Marta M. Alonso, Augustine Eze, Jasper Spitzer, Susanne V. Schmidt, Ryan J. Duchatel, Matthew D. Dun, Jason E. Cain, Li Jiang, Sylwia A. Stopka, Gerard Baquer, Michael S. Regan, Mariella G. Filbin, Nathalie Y.R. Agar, Lili Zhao, Chandan Kumar‐Sinha, Rajen Mody, Arul M. Chinnaiyan, Ryo Kurokawa, Drew Pratt, Viveka Nand Yadav, Jacques Grill, Cassie Kline, Sabine Mueller, Adam Resnick, Javad Nazarian, Joshua E. Allen, Yazmín Odia, Sharon L. Gardner, Carl Koschmann +83 moreopenalex +1 more sourcePediatric Diffuse Midline Gliomas H3 K27M-Mutant and Non-Histone Mutant Midline High-Grade Gliomas in Neurofibromatosis Type 1 in Comparison With Non-Syndromic Children: A Single-Center Pilot Study [PDF]
, 2020 Capra, V., Diana, M. C., Garibotto, F., Garre, M. L., Madia, F., Milanaccio, C., Morana, G., Piatelli, G., Piccardo, A., Rossi, A., Tortora, D., Verrico, A. +11 morecore +1 more source
