Results 11 to 20 of about 5,643 (237)

H3K27M Mutation Doesn’t Mean Worse Prognosis in Old Patients

Frontiers in Oncology, 2022
ObjectiveDiffuse midline glioma (DMG), H3K27 altered is a new entity that has become widely recognized. However, studies concerning DMG in adult patients remain rare. We did a retrospective study covering the largest amount of patients to date to analyze
Xiao Mu Hu, Xiao yu Nie, Kai lun Xu, Yin Wang, Feng Tang, Zun guo Du, Ji Xiong   +6 more
doaj   +3 more sources

Prognostic Implication of Patient Age in H3K27M-Mutant Midline Gliomas

Frontiers in Oncology, 2022
IntroductionPediatric and adult H3K27M-mutant midline gliomas have variable clinical presentations, prognoses, and molecular backgrounds. In this study, we integrated data from published studies to investigate the differences between these two groups ...
Huy Gia Vuong, Tam N. M. Ngo, Hieu Trong Le, Andrew Jea, Maya Hrachova, James Battiste, Rene McNall-Knapp, Ian F. Dunn   +7 more
doaj   +3 more sources

BAF complex maintains glioma stem cells in pediatric H3K27M glioma [PDF]

Cancer Discovery, 2022
Diffuse midline gliomas are uniformly fatal pediatric central nervous system cancers that are refractory to standard-of-care therapeutic modalities. The primary genetic drivers are a set of recurrent amino acid substitutions in genes encoding histone H3 (
Agar, Nathalie Y.R., Agnihotri, Sameer, Anastas, Jamie N., Bashyal, Puspalata, Beck, Alexander, Carcaboso, Angel M., Conway, Amy Saur, Dai, Lingling, Dempster, Joshua M., Dharia, Neekesh V., Dhe-Paganon, Sirano, Doench, John G., Filbin, Mariella G., Golub, Todd R., Goodale, Amy, Groves, Andrew, Hack, Olivia A., Hoffman, Samantha E., Jerome, William P., Jiang, Li, Jones, Kristen L., Kalani, Zohra, Kugener, Guillaume, Lareau, Caleb, Lavarino, Cinzia, Li, Deyao, Liang, Yu, Ligon, Keith L., Liu, Ilon, Marques, Joana G., Mathewson, Nathan D., Mire, Hafsa M., Monje, Michelle, Mora, Jaume, Nguyen, Quang-De, Panditharatna, Eshini, Piccioni, Federica, Qi, Jun, Quezada, Michael A., Regan, Michael S., Root, David E., Seo, Hyuk-Soo, Shaw, McKenzie L., Shi, Yang, Sigua, Logan H., Song, Kijun, Stanton, Ann-Catherine J., Stegmaier, Kimberly, Stiles, Charles D., Stopka, Sylwia, Suvà, Mario L., Trissal, Maria C., Vazquez, Francisca, Wang, Tingjian, Wyatt, Meghan   +54 more
core   +5 more sources

Histone H3K27M Mutation Overrides Histological Grading in Pediatric Gliomas [PDF]

Scientific Reports, 2020
Pediatric high-grade gliomas (HGG) are rare aggressive tumors that present a prognostic and therapeutic challenge. Diffuse midline glioma, H3K27M–mutant is a new entity introduced to HGG in the latest WHO classification.
Amal Mosaab, Moatasem El-Ayadi, Eman N. Khorshed, Nada Amer, Amal Refaat, Mohamed El-Beltagy, Zeinab Hassan, Sameh H. Soror, Mohamed Saad Zaghloul, Shahenda El-Naggar   +9 more
doaj   +3 more sources

Developing H3K27M mutant selective radiosensitization strategies in diffuse intrinsic pontine glioma

Neoplasia: An International Journal for Oncology Research, 2023
Diffuse intrinsic pontine glioma (DIPG) is a rare but highly lethal pediatric and adolescent tumor located in the pons of the brainstem. DIPGs harbor unique and specific pathological and molecular alterations, such as the hallmark lysine 27-to-methionine
Leslie A. Parsels, Daniel R Wahl, Carl Koschmann, Meredith A. Morgan, Qiang Zhang   +4 more
doaj   +3 more sources

Current Murine Models and New Developments in H3K27M Diffuse Midline Gliomas [PDF]

Frontiers in Oncology, 2019
Diffuse Midline Gliomas with Histone 3-Lysine-27-Methionine (H3K27M) mutation constitute the majority of Diffuse Intrinsic Pontine Glioma (DIPG), which is the most aggressive form of pediatric glioma with a dire prognosis. DIPG are lethal tumors found in
John P. Welby, Tatiana Kaptzan, Anton Wohl, Timothy E. Peterson, Aditya Raghunathan, Desmond A. Brown, Shiv K. Gupta, Liang Zhang, David J. Daniels   +8 more
doaj   +3 more sources

DIPG-38. Significant tumor regression of H3K27M-mutated diffuse midline glioma of the brainstem with panobinostat: a case report. [PDF]

Nature, 2022
AbstractDiffuse intrinsic pontine glioma (DIPG) and other H3K27M-mutated diffuse midline gliomas (DMGs) are universally lethal paediatric tumours of the central nervous system1. We have previously shown that the disialoganglioside GD2 is highly expressed on H3K27M-mutated glioma cells and have demonstrated promising preclinical efficacy of GD2-directed
Sonia Partap, Natasha Abadilla, Thrithi Farahzadi, Michelle Monje   +3 more
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Purine salvage promotes treatment resistance in H3K27M-mutant diffuse midline glioma

Cancer & Metabolism
Background Diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPGs), are a fatal form of brain cancer. These tumors often carry a driver mutation on histone H3 converting lysine 27 to methionine (H3K27M).
Erik R. Peterson, Peter Sajjakulnukit, Andrew J. Scott, Caleb Heaslip, Anthony Andren, Kari Wilder-Romans, Weihua Zhou, Sravya Palavalasa, Navyateja Korimerla, Angelica Lin, Alexandra O’Brien, Ayesha Kothari, Zitong Zhao, Li Zhang, Meredith A. Morgan, Sriram Venneti, Carl Koschmann, Nada Jabado, Costas A. Lyssiotis, Maria G. Castro, Daniel R. Wahl   +20 more
doaj   +3 more sources

DIPG-76. HISTONE H3 PHOSPHORYLATION IN H3K27M MIDLINE GLIOMAS [PDF]

Neuro-Oncology, 2020
Abstract Diffuse midline gliomas (DMG) patients have a dire prognosis despite radiation therapy and there is an urgent need to develop more effective treatments. DMG are characterized by heterozygous mutations in select H3 genes resulting in the replacement of lysine 27 by methionine (K27M) that leads to global epigenetic reprogramming ...
Liang Zhang, Charles Day, Edward H. Hinchcliffe, David J. Daniels   +3 more
openalex   +2 more sources

Case Report: Application of ex-vivo drug sensitivity testing to identify personalized treatment options for an adolescent with diffuse midline glioma [PDF]

Frontiers in Oncology
Diffuse midline glioma (DMG) is a pediatric brain cancer that has a dismal prognosis with limited treatment options. We present the treatment course and outcome of an adolescent male diagnosed with a thalamic DMG carrying a histone H3.3 K27M (H3K27M ...
Philip K. Tan, Philip K. Tan, Timothy J. Martins, Pamela S. Becker, Pamela S. Becker, Pamela S. Becker, Robert J. Wechsler-Reya, Robert J. Wechsler-Reya, John Ross Crawford, John Ross Crawford, John Ross Crawford   +10 more
doaj   +2 more sources