Results 231 to 237 of about 5,643 (237)

H3K27M-Positive Primary Spinal Glioblastoma Presenting with Hemorrhage—A Rare Clinical Entity

World Neurosurgery, 2019
Primary spinal glioblastoma multiforme is a rare and aggressive spinal tumor with dismal outcomes CASE DESCRIPTION: We have presented an unusual case-the first, to the best of our knowledge, to be reported-with intratumoral hemorrhage and sudden-onset quadriplegia in a patients with primary spinal glioblastoma multiforme.
Alok Uppar, Subhas K. Konar, Nandeesh B.N., Dhaval Shukla   +3 more
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Single-Cell RNA Sequencing Reveals H3K27M Glioma Oncogenic Programs

Cancer Discovery, 2018
Abstract H3K27M+ gliomas display a unique oncogenic program and are driven by OPC-like glioma cells.
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Engineered Exosomes with Ouabain for H3K27M‐Mutated DIPG Therapy

Advanced Functional Materials
AbstractDiffuse intrinsic pontine glioma (DIPG) is a highly lethal tumor that occurs in the brain stem. At present, there is no effective drug for DIPG. In this work, Na/K‐ATPase inhibitor‐ouabain (OB) is found to efficiently kill H3K27M‐mutated DIPG at low doses, inhibit tumor cell proliferation, reduce tumor stemness for the first time, demonstrating
Shaobo Shan, Junge Chen, Guangchao Qing, Luyang Xie, Bozhang Xia, Changcun Pan, Cheng Xu, Hongjuan Fang, Yichen Wan, Yun Yang, Yubo Fan, Xing‐Jie Liang, Liwei Zhang   +12 more
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EXTH-78. Pharmacologically targeting an RNA editor for H3K27M+ gliomas

Neuro-Oncology
Abstract Diffuse midline glioma (DMG) is the most aggressive and lethal pediatric brain tumor, with no effective therapies to date. Immune checkpoint blockade (ICB) has failed clinically in DMG, largely due to limited T cell infiltration, low immune checkpoint (IC) expression, and a low tumor mutational burden.
Christian Ramsoomair, Victoria Alvarez, Felipe Sarmiento, Jesus Castro, Deepa Seetharam, Danny Reinberg, Ashish Shah   +6 more
openaire   +1 more source

Combating Treatment Resistance in H3K27M-Mutant Diffuse Midline Glioma

Brain tumors are the most common solid tumor in children and account for the highest incidence of cancer-related death. Of these, diffuse midline gliomas (DMGs), including all diffuse intrinsic pontine gliomas (DIPGs), are particularly lethal. DMG tumors are often unresectable given the locations in which they form, and they are often resistant to ...
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H3K27M Mutation Reshapes the Antigenic Landscape in Diffuse Midline Glioma

Simple SummaryDiffuse midline gliomas (DMGs) are aggressive childhood brain tumours with no effective treatments. Over 80% of cases carry the histone H3K27M mutation, which alters chromatin structure and gene regulation and induce tumours growth. Immunotherapy, which uses the body’s immune system to fight cancer, relies on tumour- specific antigen ...
Tima Shamekhi, Bijun Zeng, Claire Xin Sun, Paul Daniel, Terry C.C Lim Kam Sian, Gabriel Goncalves, Grace Huang, Farnaz Fahimi, Nivedhitha Selvakumar, Erwin Tanuwidjaya, Isaac Woodhouse, Bettina Kritzer, Ralf B. Schittenhelm, Roberta Mazzieri, Jason E. Cain, Javad Nazarin, Jordan R. Hansford, Ron Firestein, Riccardo Dolcetti, Pouya Faridi   +19 more
openaire   +1 more source

Positive H3K27M cytology in cerebrospinal fluid in diffuse midline glioma

Neurological Sciences
Honami Kawai, Takaaki Hattori, Yutaka Nakajima, Takanori Yokota, Iichiroh Onishi   +4 more
openaire   +2 more sources