Results 31 to 40 of about 5,643 (237)

Clinical Presentation, MRI findings and Molecular insights in Diffuse Intrinsic Pontine Gliomas (DIPGs): A Comprehensive Review.

Archives of Pediatric Neurosurgery, 2023
Diffuse intrinsic pontine glioma (DIPG) is a highly aggressive and the most common brainstem tumor affecting pediatric patients, with a poor prognosis and limited treatment options. Despite extensive research, the median overall survival remains low, and
Gustavo Novelino Simao
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Domain Model Explains Propagation Dynamics and Stability of Histone H3K27 and H3K36 Methylation Landscapes [PDF]

, 2020
Chromatin states must be maintained during cell proliferation to uphold cellular identity and genome integrity. Inheritance of histone modifications is central in this process. However, the histone modification landscape is challenged by incorporation of
Alabert, Allshire, Berry, Blackledge, Blasi, Coleman, Cooper, Ernst, Ferrari, Fröhlich, Hass, Healy, Hindmarsh, Hojfeldt, Huang, Højfeldt, Jani, Jasencakova, Jung, Justin, King, Langmead, Laprell, Laugesen, Lee, Loos, Loyola, Lu, MacLean, Maier, Margueron, Marks, McCabe, Mohammad, Noberini, Oksuz, Petryk, Poepsel, Reinberg, Reveron-Gomez, Sanulli, Scharf, Schmitges, Schuettengruber, Schwarz, Stafford, Stapor, Streubel, Tatton-Brown, van Mierlo, Voigt, Wasserman, Xu, Xu, Yu, Yu, Yuan, Zang, Zheng   +58 more
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PRC2 engages a bivalent H3K27M-H3K27me3 dinucleosome inhibitor [PDF]

Proceedings of the National Academy of Sciences, 2019
Significance A subset of deadly pediatric brain tumors called diffuse intrinsic pontine gliomas express a mutant histone H3 with a lysine-to-methionine substitution at position 27 (H3K27M), which has been shown to drive tumorigenesis in these cancers.
Katharine L, Diehl, Eva J, Ge, Daniel N, Weinberg, Krupa S, Jani, C David, Allis, Tom W, Muir   +5 more
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Histone H3-wild type diffuse midline gliomas with H3K27me3 loss are a distinct entity with exclusive EGFR or ACVR1 mutation and differential methylation of homeobox genes

Scientific Reports, 2023
Diffuse midline gliomas (DMG) harbouring H3K27M mutation are paediatric tumours with a dismal outcome. Recently, a new subtype of midline gliomas has been described with similar features to DMG, including loss of H3K27 trimethylation, but lacking the ...
Pamela Ajuyah, Chelsea Mayoh, Loretta M. S. Lau, Paulette Barahona, Marie Wong, Hazel Chambers, Fatima Valdes-Mora, Akanksha Senapati, Andrew J. Gifford, Colleen D’Arcy, Jordan R. Hansford, Neevika Manoharan, Wayne Nicholls, Molly M. Williams, Paul J. Wood, Mark J. Cowley, Vanessa Tyrrell, Michelle Haber, Paul G. Ekert, David S. Ziegler, Dong-Anh Khuong-Quang   +20 more
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H3K27M mutant diffuse midline glioma: a case report.

European review for medical and pharmacological sciences, 2020
Diffuse midline glioma with H3K27M mutation is a new tumor type of WHO central nervous system tumor classification. It often occurs in the midline structure and usually has a poor prognosis.A 38-year-old male patient presented with 2 years history of right limb with facial numbness, tumors in the left thalamic region and lateral ventricle was detected ...
Luo, Y., Zeng, L., Xie, X.-Q., Wang, F., Liu, Y.-Z., Kang, J.-B., Li, X.-F., Wu, D.-B., Qu, B.-L.   +8 more
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Diagnostic and therapeutical approaches to H3K27M-altered diffuse midline glioma in children: a review

Онкогематология, 2023
H3K27M-altered diffuse midline gliomas are the most devastating pediatric brain tumors. These tumors are characterized by lesion of central nervous system midline structures, diffuse infiltrative growth and fatal prognosis.
D. A. Morgacheva, D. A. Sitovskaia, Yu. V. Dinikina   +2 more
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Patterns of Failure After Radiation Therapy in Primary Spinal High-Grade Gliomas: A Single Institutional Analysis [PDF]

, 2022
Background Primary spinal high-grade gliomas (S-HGG) are rare aggressive tumors; radiation therapy (RT) often plays a dominant role in management. We conducted a single-institution retrospective review to study the clinicopathological features and ...
Alvarez-Breckenridge, Christopher, De Groot, John, Fuller, Gregory, Ghia, Amol, Harrison, Rebecca, Johnson, Jason Michael, Kamiya-Matsuoka, Carlos, Khose, Swapnil, Li, Jing, Lin, Frank, Loghin, Monica, McAleer, Mary Frances, McGovern, Susan L, O\u27Brien, Barbara, Paulino, Arnold C, Pokhylevych, Halyna, Prabhu, Sujit, Puduvalli, Vinay K, Rhines, Larry, Sandberg, David I, Tatsui, Claudio, Upadhyay, Rituraj, Weinberg, Jeffery S, Yeboa, Debra Nana, Zaky, Wafik   +24 more
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Clinical Features and Molecular Markers on Diffuse Midline Gliomas With H3K27M Mutations: A 43 Cases Retrospective Cohort Study

Frontiers in Oncology, 2021
PurposeDiffuse midline gliomas (DMG) with H3K27M mutations have been identified as a rare distinctive entity with unique genetic features, varied molecular alterations, and poor prognosis.
Yuan Wang, Lan-lan Feng, Pei-gang Ji, Jing-hui Liu, Shao-chun Guo, Yu-long Zhai, Eric W. Sankey, Yue Wang, Yan-rong Xue, Yan-rong Xue, Na Wang, Miao Lou, Meng Xu, Min Chao, Guo-Dong Gao, Yan Qu, Li Gong, Liang Wang   +17 more
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A homogeneous treatment for non-DIPG diffuse midline glioma [PDF]

, 2023
Introduction: The H3K27M-mutant diffuse midline glioma (DMG) was first included in the World Health Organization (WHO) Classification of central nervous system (CNS) tumors in 2016, and confirmed in its fifth edition.
Antonelli, Manila, Barretta, Francesco, Biassoni, Veronica, Chiaravalli, Stefano, De Cecco, Loris, Gandola, Lorenza, Gattuso, Giovanna, Massimino, Maura, Pecori, Emilia, Podda, Marta, Schiavello, Elisabetta   +10 more
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Diffuse midline glioma H3K27M mutation in adult: A case report

Annals of Medicine & Surgery, 2022
Diffuse midline glioma with H3 K27M mutation is a new tumor entity from 2016 which is highly aggressive and classified as a WHO Grade IV tumor regardless of histopathologic features. DMG is an aggressive tumor with a poor prognosis, predominating in children and rarely in adults.
Bhattarai, Ayush Mohan, Mainali, Gaurab, Jha, Pinky, Karki, Pearlbiga, Adhikari, Abhishek, Pandit, Ayushma, Bhattarai, Ashish Mohan   +6 more
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