Results 41 to 50 of about 5,643 (237)

Emerging roles of telomeric chromatin alterations in cancer [PDF]

, 2019
Telomeres, the nucleoprotein structures that cap the ends of eukaryotic chromosomes, play important and multiple roles in tumorigenesis. Functional telomeres need the establishment of a protective chromatin structure based on the interplay between the ...
Biroccio, Annamaria, Cacchione, Stefano, Rizzo, Angela   +2 more
core   +1 more source

Microfluidic active loading of single cells enables analysis of complex clinical specimens [PDF]

, 2013
A fundamental trade-off between flow rate and measurement precision limits performance of many single-cell detection strategies, especially for applications that require biophysical measurements from living cells within complex and low-input samples.
Malinowski, Seth W., Touat, Mehdi, Ligon, Keith L., Calistri, Nicholas L, Kimmerling, Robert John, Stevens, Mark M., Olcum, Selim A., Manalis, Scott R   +7 more
core   +5 more sources

The diverse landscape of histone-mutant pediatric high-grade gliomas: A narrative review

Glioma, 2022
Pediatric high-grade gliomas (pHGGs) are the leading cause of tumor-related death in children, with diffuse midline gliomas representing the worst prognoses.
Evan Lubanszky, Cynthia Hawkins
doaj   +1 more source

H3K27M in Gliomas Causes a One-Step Decrease in H3K27 Methylation and Reduced Spreading within the Constraints of H3K36 Methylation

Cell Reports, 2020
Summary: The discovery of H3K27M mutations in pediatric gliomas marked a new chapter in cancer epigenomics. Numerous studies have investigated the effect of this mutation on H3K27 trimethylation, but only recently have we started to realize its ...
Ashot S. Harutyunyan, Haifen Chen, Tianyuan Lu, Cynthia Horth, Hamid Nikbakht, Brian Krug, Caterina Russo, Eric Bareke, Dylan M. Marchione, Mariel Coradin, Benjamin A. Garcia, Nada Jabado, Jacek Majewski   +12 more
doaj   +1 more source

Pediatric posterior fossa ependymoma and metabolism: A narrative review

Glioma, 2021
Ependymomas are a lethal central nervous system (CNS) tumor found in both adults and children. Recent efforts have focused on risk stratification by classifying the molecular variants of CNS ependymoma.
Katharine E Halligan, Antony Michealraj Kulandaimanuvel, Andrea Cruz, James T Felker, Craig Daniels, Michael D Taylor, Sameer Agnihotri   +6 more
doaj   +1 more source

Non-invasive methods of molecular diagnosis, clinical monitoring and approaches to the personalized therapy of diffuse midline glioma

Сибирский онкологический журнал, 2023
The purpose of the study was to summarize and analyze modern data about non-invasive methods of molecular diagnosis and approaches to the personalized therapy of diffuse midline glioma (DMG). Material and Methods.
E. V. Petersen, D. A. Chudakova, D. B. Erdyneeva, A. A. Kalinkin, R. Claros, E. Y. Shabalina, D. A. Gudkov, О. A. Mynbaev, I. V. Reshetov   +8 more
doaj   +1 more source

Specific detection of methionine 27 mutation in histone 3 variants (H3K27M) in fixed tissue from high-grade astrocytomas [PDF]

, 2014
Studies in pediatric high-grade astrocytomas (HGA) by our group and others have uncovered recurrent somatic mutations affecting highly conserved residues in histone 3 (H3) variants. One of these mutations leads to analogous p.Lys27Met (K27M) mutations in
Albrecht, Steffen, Bechet, Denise, Benlimane, Naciba, David Allis, C., Ellezam, Benjamin, Faury, Damien, Fiset, Pierre-Olivier, Gielen, Gerrit G. H., Jabado, Nada, Kieran, Mark W., Korshunov, Andrey, Lewis, Peter W., Ligon, Keith L., Lu, Chao, Pfister, Stefan M., Pietsch, Torsten, Rousso, Caterina   +16 more
core   +1 more source

Molecular, pathological, radiological, and immune profiling of non-brainstem pediatric high-grade glioma from the HERBY phase II randomized trial [PDF]

, 2018
The HERBY trial was a phase II open-label, randomized, multicenter trial evaluating bevacizumab (BEV) in addition to temozolomide/radiotherapy in patients with newly diagnosed non-brainstem high-grade glioma (HGG) between the ages of 3 and 18 years.
Brouwer-Visser, Jurriaan, Burford, Anna, Capper, David, Figarella-Branger, Dominique, Garcia, Josep, Garrè, Maria Luisa, Giangaspero, Felice, Grill, Jacques, Haberler, Christine, Izquierdo, Elisa, Jacques, Thomas S., Jaspan, Tim, Jones, Chris, Jones, David T.W., Mackay, Alan, Massimino, Maura, Molinari, Valeria, Morgan, Paul S., Pfister, Stefan M., Pietsch, Torsten, Raman, Pichai, Resnick, Adam C., Rodriguez, Daniel, Smith, Helen, Tam, Rachel, Thakur, Meghna Das, Varlet, Pascale, Varlet, Pascle, Vassal, Gilles, Waanders, Angela J., Würdinger, Thomas   +30 more
core   +7 more sources

Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways [PDF]

, 2023
UNLABELLED Patients with H3K27M-mutant diffuse midline glioma (DMG) have no proven effective therapies. ONC201 has recently demonstrated efficacy in these patients, but the mechanism behind this finding remains unknown.
Arrillaga-Romany, Isabel, Batchelor, Tracy T, Beccaria, Kevin, Butowski, Nicholas A, Chi, Andrew, Chung, Chan, Cloughesy, Timothy F, Daghistani, Doured, de Groot, John, Deogharkar, Akash, Ellingson, Benjamin M, et al, Hall, Matthew D, Harrison, Rebecca A, Ji, Sunjong, Kawakibi, Abed Rahman, Kim, Michelle M, Mehta, Minesh, Mota, Mateus, Mueller, Sabine, Nazarian, Javad, Pun, Matthew, Ramage, Samuel, Shonka, Nicole, Sumrall, Ashley, Sweha, Stefan R, Tarapore, Rohinton S, Varlet, Pascale, Venneti, Sriram, Waszak, Sebastian M, Wen, Patrick Y   +30 more
core   +1 more source

Common molecular features of H3K27M DMGs and PFA ependymomas map to hindbrain developmental pathways

Acta Neuropathologica Communications, 2023
Globally decreased histone 3, lysine 27 tri-methylation (H3K27me3) is a hallmark of H3K27-altered diffuse midline gliomas (DMGs) and group-A posterior fossa ependymomas (PFAs).
Matthew Pun, Drew Pratt, Patricia R. Nano, Piyush K. Joshi, Li Jiang, Bernhard Englinger, Arvind Rao, Marcin Cieslik, Arul M. Chinnaiyan, Kenneth Aldape, Stefan Pfister, Mariella G. Filbin, Aparna Bhaduri, Sriram Venneti   +13 more
doaj   +1 more source