Results 51 to 60 of about 5,643 (237)

Adult Brainstem Gliomas With H3K27M Mutation: Radiology, Pathology, and Prognosis [PDF]

Journal of Neuropathology & Experimental Neurology, 2018
Adult brainstem gliomas are difficult to classify based on radiologic and histologic features. A K27M mutation in histone 3 has been described to identify high-grade midline gliomas associated with a particularly unfavorable prognosis. While initially considered a pediatric entity, it is now known that H3K27M-mutant brainstem gliomas occur in all age ...
Elena V, Daoud, Veena, Rajaram, Chunyu, Cai, Robert J, Oberle, Gregory R, Martin, Jack M, Raisanen, Charles L, White, Chan, Foong, Bruce E, Mickey, Edward, Pan, Kimmo J, Hatanpaa   +10 more
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VRK3 depletion induces cell cycle arrest and metabolic reprogramming of pontine diffuse midline glioma - H3K27 altered cells

Frontiers in Oncology, 2023
We previously identified VRK3 as a specific vulnerability in DMG-H3K27M cells in a synthetic lethality screen targeting the whole kinome. The aim of the present study was to elucidate the mechanisms by which VRK3 depletion impact DMG-H3K27M cell fitness.
Virginie Menez, Thomas Kergrohen, Tal Shasha, Claudia Silva-Evangelista, Ludivine Le Dret, Lucie Auffret, Chloé Subecz, Manon Lancien, Yassine Ajlil, Irma Segoviano Vilchis, Kévin Beccaria, Kévin Beccaria, Thomas Blauwblomme, Estelle Oberlin, Jacques Grill, Jacques Grill, David Castel, Marie-Anne Debily, Marie-Anne Debily   +18 more
doaj   +1 more source

Intersection of brain development and paediatric diffuse midline gliomas: potential role of microenvironment in tumour growth [PDF]

, 2018
Diffuse intrinsic pontine glioma (DIPG) is a devastating and incurable paediatric brain tumour with a median overall survival of 9 months. Until recently, DIPGs were treated similarly to adult gliomas, but due to the advancement in molecular and imaging ...
Fillmore, Helen, Loveson, Katie
core   +1 more source

Clinical, radiologic, pathologic, and molecular characteristics of long-term survivors of diffuse intrinsic pontine glioma (DIPG): a collaborative report from the International and European Society for Pediatric Oncology DIPG registries [PDF]

, 2018
Purpose Diffuse intrinsic pontine glioma (DIPG) is a brainstem malignancy with a median survival of < 1 year. The International and European Society for Pediatric Oncology DIPG Registries collaborated to compare clinical, radiologic, and ...
Antonelli, Manila, Antonelli, Manila, Bailey, Simon, Bartels, Ute, Baugh, Joshua, Benesch, Martin, Biassoni, Veronica, Bison, Brigitte, Boddaert, Nathalie, Bouffet, Eric, Broniscer, Alberto, Broxson, Emmett, Calmon, Raphael, Castel, David, Chaney, Brooklyn, Chintagumpala, Murali, Colditz, Niclas, Comito, Melanie, Dholaria, Hetal, Doughman, Renee, Drissi, Rachid, Foreman, Nicholas K., Fouladi, Maryam, Fuller, Christine, Gerber, Nicolas U., Giagnacovo, Marzia, Gielen, Gerrit H., Giraud, G´eraldine, Goldman, Stewart, Gottardo, Nicholas, Grill, Jacques, Grotzer, Michael A., Hargrave, Darren, Hassall, Timothy, Hawkins, Cynthia, Hoffman, Lindsey M., Hoffmann, Marion, Hulleman, Esther, Jabado, Nada, Jadrijevic Cvrlje, Filip, Jones, Blaise, Jones, Chris, Jones, David T. W., Kaspers, Gertjan J. L., Khatua, Soumen, Kieran, Mark W., Kramm, Christof M., Lane, Adam, Leach, James, Leary, Sarah, Massimino, Maura, Miles, Lili, Minturn, Jane, Modena, Piergiorgio, Nazarian, Javad, Packer, Roger, Pfaff, Elke, Pfister, Stefan M., Pietsch, Torsten, Puget, Stephanie, Sanchez, Esther, Shih, Chie-Schin, Solanki, Guirish A., Sophie Carret, Anne, Sturm, Dominik, van Vuurden, Dannis G., Vandertop, William P., Varlet, Pascale, Veldhuijzen van Zanten, Sophie E. M., von Bueren, Andr´e O., Warmuth-Metz, Monika, Warren, Katherine E., Yanez Escorza, Nancy, Ziegler, David S.   +73 more
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Haploinsufficiency of NFKBIA reshapes the epigenome antipodal to the IDH mutation and imparts disease fate in diffuse gliomas [PDF]

, 2023
Genetic alterations help predict the clinical behavior of diffuse gliomas, but some variability remains uncorrelated. Here, we demonstrate that haploinsufficient deletions of chromatin-bound tumor suppressor NFKB inhibitor alpha (NFKBIA) display distinct
Bertran, Joan, Bredel, Markus, Chan, Timothy A, Espinosa, Lluís, et al, Fleming, Jessica L, Furnari, Frank B, Grosu, Anca-Ligia, Haque, S Jaharul, Harsh, Griffith R, Hentschel, Bettina, Kim, Hyunsoo, Kollmeyer, Thomas M, Lobo-Jarne, Teresa, Malta, Tathiane M, McElroy, Joseph P, Meng, Wei, Merati, Aran, Miller, C Ryan, Nagaraja, Surya, Nair, Sindhu, Natsume, Atsushi, Ogawa, Seishi, Quezada, Michael A, Rajbhandari, Rajani, Scholtens, Denise M, Solé, Laura, Thudi, Nanda K, Webb, Amy, Weber, Ruthild G, White, Jaclyn J   +30 more
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ONC 201 PRACTICE IN DIFFUSE MIDLINE GLIOMA (H3K27M MUTANT)

Hematology, Transfusion and Cell Therapy, 2021
Objective: Diffuse Midline Gliomas (DMG), H3 K27M-mutant have the poorest prognosis among all pediatric high-grade gliomas, with a median survival of 9-11 months. Although radiotherapy (RT) is standard treatment for these tumors, unfortunately there has been no approved and effective treatment which completely diminishes the tumor yet.
Bahattin Tanrıkulu, M. Memet Özek, Cengiz Canpolat, Ahmet Harun Yaşar, Ayça Erşen Danyeli   +4 more
openaire   +2 more sources

A H3K27M-targeted vaccine in adults with diffuse midline glioma

Nature Medicine, 2023
AbstractSubstitution of lysine 27 to methionine in histone H3 (H3K27M) defines an aggressive subtype of diffuse glioma. Previous studies have shown that a H3K27M-specific long peptide vaccine (H3K27M-vac) induces mutation-specific immune responses that control H3K27M+ tumors in major histocompatibility complex-humanized mice.
Niklas Grassl, Isabel Poschke, Katharina Lindner, Lukas Bunse, Iris Mildenberger, Tamara Boschert, Kristine Jähne, Edward W. Green, Ingrid Hülsmeyer, Simone Jünger, Tobias Kessler, Abigail K. Suwala, Philipp Eisele, Michael O. Breckwoldt, Peter Vajkoczy, Oliver M. Grauer, Ulrich Herrlinger, Joerg-Christian Tonn, Monika Denk, Felix Sahm, Martin Bendszus, Andreas von Deimling, Frank Winkler, Wolfgang Wick, Michael Platten, Katharina Sahm   +25 more
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Biophysical characterization of histone H3.3 K27M point mutation [PDF]

, 2018
K
Boros-Oláh, Beáta, Hetey, Szabolcs, Karányi, Zsolt, Kuik-Rózsa, Tímea, Li, Qiuzhen, Roszik, Jason, Szabó, Zoltán, Szalóki, Nikoletta, Székvölgyi, Lóránt, Tóth, Katalin Ágnes, Vámosi, György   +10 more
core   +1 more source

H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis

Nature Communications, 2019
Lysine27-to-methionine mutations in histone H3 genes (H3K27M) occur in a subgroup of gliomas and decrease genome-wide H3K27 trimethylation. Here the authors utilise primary H3K27M tumour lines and isogenic CRISPR-edited controls and show that H3K27M ...
Ashot S. Harutyunyan, Brian Krug, Haifen Chen, Simon Papillon-Cavanagh, Michele Zeinieh, Nicolas De Jay, Shriya Deshmukh, Carol C. L. Chen, Jad Belle, Leonie G. Mikael, Dylan M. Marchione, Rui Li, Hamid Nikbakht, Bo Hu, Gael Cagnone, Warren A. Cheung, Abdulshakour Mohammadnia, Denise Bechet, Damien Faury, Melissa K McConechy, Manav Pathania, Siddhant U. Jain, Benjamin Ellezam, Alexander G. Weil, Alexandre Montpetit, Paolo Salomoni, Tomi Pastinen, Chao Lu, Peter W. Lewis, Benjamin A. Garcia, Claudia L. Kleinman, Nada Jabado, Jacek Majewski   +32 more
doaj   +1 more source

Defining the chromatin signature of inducible genes in T cells [PDF]

, 2016
BACKGROUND Specific chromatin characteristics, especially the modification status of the core histone proteins, are associated with active and inactive genes. There is growing evidence that genes that respond to environmental or developmental signals may
Bunting, Karen, Chen, Xinxin, Hardy, Kristine, Lim, Pek S, Ma, Lina, Peng, Kaiman, Shannon, Mary F   +6 more
core   +1 more source