A case of adult-onset diffuse midline glioma diagnosed by histone H3K27M immunostaining after death, which required differentiation from brainstem encephalitis and myelitis [PDF]
, 2023 H3K27M-mutant diffuse midline glioma is a malignant glioma that was newly added to the World Health Organization classification in 2016. In diffuse midline glioma, the H3K27M-mutant sometimes develops sub-acutely and requires a differential diagnosis ...
Arakawa, Yoshiki +8 more
core +1 more source
Glucosylceramide synthase inhibitors induce ceramide accumulation and sensitize H3K27 mutant diffuse midline glioma to irradiation [PDF]
, 2023 H3K27M mutant (mut) diffuse midline glioma (DMG) is a lethal cancer with no effective cure. The glycosphingolipids (GSL) metabolism is altered in these tumors and could be exploited to develop new therapies.
Alt, Francesca +15 more
core +1 more source
Histone-mutant glioma presenting as diffuse leptomeningeal disease
CNS Oncology, 2021 Glioblastoma multiforme is the most common malignant primary brain tumor in adults. Histone H3 mutations have been identified in pediatric and adult gliomas, with H3K27M mutations typically associated with a posterior fossa midline tumor location and ...
Tanvi Nadkarni +7 more
doaj +1 more source
Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma. [PDF]
, 2017 We collated data from 157 unpublished cases of pediatric high-grade glioma and diffuse intrinsic pontine glioma and 20 publicly available datasets in an integrated analysis of >1,000 cases.
Adam Resnick +116 more
core +8 more sources
Frontiers in Genetics, 2021 Somatic mutations in histone encoding genes result in gross alterations in the epigenetic landscape. Diffuse intrinsic pontine glioma (DIPG) is a pediatric high-grade glioma (pHGG) and one of the most challenging cancers to treat, with only 1% surviving ...
Katarzyna B. Leszczynska +4 more
doaj +1 more source
Molecular alterations in the integrated diagnosis of pediatric glial and glioneuronal tumors: A single center experience [PDF]
, 2022 Objectives: Tumors of the central nervous system (CNS) are the most common pediatric solid tumors, where low grade (LGG) and high grade gliomas (HGG) represent up to 55% of CNS tumors.
Cardoso, Nazarena +7 more
core +1 more source
RARE-37. TREATMENT OF H3K27M MUTANT GLIOMAS WITH PANOBINOSTAT [PDF]
Neuro-Oncology, 2019 Abstract Panobinostat (PBST) is a histone deacetylase inhibitor with biologic rationale in the treatment of gliomas harboring H3 K27M mutation. METHODS We performed a retrospective medical record review of adult patients with H3 K27M
Samantha Balakrishnan +4 more
openaire +1 more source
Cancer Medicine, 2023 Background H3K27M mutation status significantly affects the prognosis of patients with diffuse midline gliomas (DMGs), but this tumor presents a high risk of pathological acquisition.
Bowen Huang +7 more
doaj +1 more source
Upfront Biology-Guided Therapy in Diffuse Intrinsic Pontine Glioma: Therapeutic, Molecular, and Biomarker Outcomes from PNOC003 [PDF]
, 2022 PURPOSE PNOC003 is a multicenter precision medicine trial for children and young adults with newly diagnosed diffuse intrinsic pontine glioma (DIPG).
Banerjee, Anu +27 more
core +1 more source
Nature Communications, 2023 The spatial organisation of diffuse midline glioma-H3K27M mutant (DMG) and glioblastoma (GBM) remains to be investigated. Here, the authors integrate short-read and long-read spatial profiling of DMG and GBM to identify regulatory programs and cellular ...
Yanming Ren +28 more
doaj +1 more source