Results 71 to 80 of about 5,643 (237)

Diffuse midline glioma with H3-K27M mutation

Medicine, 2022
. Introduction:. Diffuse midline glioma with H3-K27M mutation is an infiltrative high-grade glioma, with predominantly astrocytic differentiation. Patient concerns:.
Yi-Hua Wang, Bachelor, Jian Gu, Master, Juan-Han Yu, MD, PhD, Lin Fu, MD, PhD, Qing-Chang Li, MD, PhD, Xue-Shan Qiu, MD, PhD, En-Hua Wang, MD, PhD   +6 more
doaj   +1 more source

Diffuse glioma with FGFR3‐TACC3 fusion in adults is not a homogenous clinicopathological and molecular entity

The Journal of Pathology: Clinical Research, Volume 11, Issue 6, November 2025.
Abstract Adult diffuse gliomas with FGFR3‐TACC3 (F3T3) fusion are rare and highly heterogeneous central nervous system (CNS) tumors. Current research on the biological behavior of these tumors is limited, especially regarding whether histopathologically low‐grade tumors are indolent or represent early‐stage high‐grade tumors, thereby posing challenges ...
Xiaoli Su, Jiawen Wu, Pingling Wang, Liwen Hu, Yupeng Chen, Caihong Ren, Fangling Song, Hangrui Lin, Chenlin Ji, Yucheng xie, Xingfu Wang   +10 more
wiley   +1 more source

Oxidative phosphorylation at the crossroads of cancer: Metabolic orchestration, stromal collusion, and emerging therapeutic horizons

Interdisciplinary Medicine, Volume 3, Issue 6, November 2025.
Although most cancer cells rely on aerobic glycolysis, Oxidative phosphorylation (OXPHOS) remains essential for their survival, proliferation, and metastasis. With the emergence of OXPHOS‐targeted drugs, its therapeutic potential is becoming increasingly evident.
Keke Chen, Bo Wang, Hongying Shu, Jianxin Lyu, Wei Cui, Hezhi Fang   +5 more
wiley   +1 more source

Deep Learning for the Prediction of the Survival of Midline Diffuse Glioma with an H3K27M Alteration

Brain Sciences, 2023
Background: The prognosis of diffuse midline glioma (DMG) patients with H3K27M (H3K27M-DMG) alterations is poor; however, a model that encourages accurate prediction of prognosis for such lesions on an individual basis remains elusive.
Bowen Huang, Tengyun Chen, Yuekang Zhang, Qing Mao, Yan Ju, Yanhui Liu, Xiang Wang, Qiang Li, Yinjie Lei, Yanming Ren   +9 more
doaj   +1 more source

RARE-30. PEDIATRIC GLIOBLASTOMA IN THE POST-TEMOZOLOMIDE ERA: OUTCOMES AND CHARACTERISTICS [PDF]

, 2019
INTRODUCTION Glioblastoma (GBM) is the most common brain tumor, however, is a rare occurrence in children and is poorly characterized. We evaluated the characteristics and outcomes of pediatric GBM (pGBM).
Aghi, Manish, Berger, Mitchel, Chandra, Ankush, Gupta, Nalin, McDermott, Mike, Oh, Taemin, Shah, Sumedh, Wadhwa, Harsh   +7 more
core  

Identification of prognostic markers in diffuse midline gliomas H3K27M‐mutant

Brain Pathology, 2019
AbstractPediatric diffuse midline gliomas are devastating diseases. Among them, diffuse midline gliomas H3K27M‐mutant are associated with worse prognosis. However, recent studies have highlighted significant differences in clinical behavior and biological alterations within this specific subgroup.
Dufour, Charlotte, Perbet, Romain, Leblond, Pierre, Vasseur, Romain, Stechly, Laurence, Pierache, Adeline, Reyns, Nicolas, Touzet, Gustavo, Le Rhun, Emilie, Vinchon, Matthieu, Maurage, Claude‐alain, Escande, Fabienne, Renaud, Florence   +12 more
openaire   +3 more sources

EZH2i EPZ-6438 and HDACi vorinostat synergize with ONC201/TIC10 to activate integrated stress response, DR5, reduce H3K27 methylation, ClpX and promote apoptosis of multiple tumor types including DIPG

Neoplasia: An International Journal for Oncology Research, 2021
ONC201/TIC10 activates TRAIL signaling through ATF4 and the integrated stress response (ISR). ONC201 demonstrated tumor regressions and disease stability in patients with histone H3K27M-mutated midline-glioma.
Yiqun Zhang, Lanlan Zhou, Howard Safran, Robyn Borsuk, Rishi Lulla, Nikos Tapinos, Attila A. Seyhan, Wafik S. El-Deiry   +7 more
doaj   +1 more source

Glucose transporter Glut1 controls diffuse invasion phenotype with perineuronal satellitosis in diffuse glioma microenvironment [PDF]

, 2021
岐阜大学(Gifu University)博士(医学)博士論文 (Doctoral dissertation)以下に掲載 Neuro-Oncology Advances (2021) 3(1), vdaa150doctoral ...
398474, 宮居, 雅文
core   +1 more source

Novel Diffuse Midline Glioma‐on‐Chip Recapitulating Tumor Biophysical Microenvironment to Assess the Heterogeneity of Response to Therapies

Small, Volume 21, Issue 45, November 13, 2025.
In this work, a DMG‐on‐Chip (DoC) is set up, with a geometry yielding gradients of nutrient and oxygen depletion, to recapitulate this trait of tumor microenvironment‐driven heterogeneity. The biophysical and biochemical characterization of this microsystem via fluorescence microscopy analyses highlights the acidification of the tumor core, along with ...
Lisa Terrassoux, Calypso Hazard, Agathe Laratte, Joanne Balsamelli, Mélanie Arcicasa, Elisa Fong, Léo Baland, Fabrice Soncin, Giovanni Cappello, Claude‐Alain Maurage, Sebastien Janel, Antony Bazir, Fabrizio Cleri, Anthony Treizebre, Eric Lartigau, Yousr Rekik, Samuel Meignan, Alessandro Furlan   +17 more
wiley   +1 more source

Flank Pain as a First Symptom of a Diffuse Midline Glioma

Case Reports in Neurology, 2023
Diffuse midline gliomas are a new entity in the WHO Classification of Tumors of the Central Nervous System, corresponding to grade 4 gliomas. The diagnostic pathognomonic feature is the presence of a H3K27M mutation.
Burc Bassa, Achim Battmann, Eva Maria Craemer, Uta Meyding-Lamadé   +3 more
doaj   +1 more source