Results 1 to 10 of about 3,196 (190)

Immunogenic and Protective Properties of Recombinant Hemagglutinin of Influenza A (H5N8) Virus

Vaccines
In this study, we characterized recombinant hemagglutinin (HA) of influenza A (H5N8) virus produced in Chinese hamster ovary cells (CHO-K1s). Immunochemical analysis showed that the recombinant hemagglutinin was recognized by the serum of ferrets ...
Mariya B Borgoyakova, Elena V Tigeeva, Dmitry N Shcherbakov   +2 more
exaly   +6 more sources

Impact of Individual Viral Gene Segments from Influenza A/H5N8 Virus on the Protective Efficacy of Inactivated Subtype-Specific Influenza Vaccine

Pathogens, 2021
Since its emergence in 2014, the highly pathogenic avian influenza H5N8 virus has continuously and rapidly spread worldwide in the poultry sector resulting in huge economic losses.
Yassmin Moatasim, Ahmed Kandeil, Ahmed Mostafa   +2 more
exaly   +4 more sources

Novel Clade 2.3.4.4b Highly Pathogenic Avian Influenza A H5N8 and H5N5 Viruses in Denmark, 2020

Viruses, 2021
Since late 2020, outbreaks of H5 highly pathogenic avian influenza (HPAI) viruses belonging to clade 2.3.4.4b have emerged in Europe. To investigate the evolutionary history of these viruses, we performed genetic characterization on the first HPAI ...
Yuan Liang, Ramona Trebbien, Lars E Larsen   +2 more
exaly   +4 more sources

AddaVax-Adjuvanted H5N8 Inactivated Vaccine Induces Robust Humoral Immune Response against Different Clades of H5 Viruses

Vaccines, 2022
Since some cases of human infections with H5N8 avian influenza virus have been reported and caused great concern in recent years, it is important to develop an effective vaccine for human use to prevent a potential H5N8 pandemic.
Jian Luo, Xiuling Li, Li Xiuling
exaly   +4 more sources

Comparative Virological and Pathogenic Characteristics of Avian Influenza H5N8 Viruses Detected in Wild Birds and Domestic Poultry in Egypt during the Winter of 2016/2017

Viruses, 2019
The surveillance and virological characterization of H5N8 avian influenza viruses are important in order to assess their zoonotic potential. The genetic analyses of the Egyptian H5N8 viruses isolated through active surveillance in wild birds and domestic
Yassmin Moatasim, Ahmed Kandeil, Basma Emad Aboulhoda   +2 more
exaly   +4 more sources

Construction and Immune Strategy Optimization of a Vaccine Strain for Influenza A (H5N8) Subtype [PDF]

Viruses
Multiple subtypes of avian influenza virus (AIV), including H5N1, H5N6, and H5N8 viruses, are currently co-circulating in wild birds and poultry and causing sporadic human infections. Vaccine development is essential for pandemic preparedness.
Shuxia Zhang, Jing Tang, Liqi Liu, Hejiang Wei, Li Xin, Kang Xiao, Jinbo Xiao, Jie Dong, Zi Li, Hongyan Bai, Shuaixing Wang, Wenfei Zhu, Lei Yang, Shumei Zou, Dayan Wang   +14 more
doaj   +4 more sources

Divergent Reassortment and Transmission Dynamics of Highly Pathogenic Avian Influenza A(H5N8) Virus in Birds of China During 2021

Frontiers in Microbiology, 2022
Highly pathogenic influenza A(H5N8) viruses had caused several outbreaks among wild bird and poultry populations across the globe, and strikingly, caused human infection, posing serious public health concerns.
Jiahao Zhang, Wenting Zhong
exaly   +3 more sources

A Monoclonal Antibody ELISA-Based Assay for Measuring the Potency of Candidate H5 Clade 2.3.4.4b Pandemic Influenza Vaccines. [PDF]

Influenza Other Respir Viruses
ABSTRACT Background The single radial immunodiffusion (SRID) assay is used to determine the potency of inactivated influenza vaccines. Nevertheless, development of alternative influenza vaccine potency assays with greater sensitivity and less reliance on large quantities of reference reagents is needed.
Odin M, Schmeisser F, Soto J, Weir JP.
europepmc   +2 more sources

Genetic and Antigenic Characteristics of Highly Pathogenic Avian Influenza A(H5N8) Viruses Circulating in Domestic Poultry in Egypt, 2017–2021

Microorganisms, 2022
In Egypt, the endemicity of avian influenza viruses is a serious concern. Since 2016, several outbreaks of H5N8 have been recorded among domestic poultry in various areas of the country. Active surveillance of domestic poultry across several governorates
Ahmed Kandeil, Yassmin Moatasim, Adam Rubrum   +2 more
exaly   +3 more sources

The C-terminus of non-structural protein 1 (NS1) in H5N8 clade 2.3.4.4 avian influenza virus affects virus fitness in human cells and virulence in mice

Emerging Microbes and Infections, 2021
Avian influenza viruses (AIV) H5N8 clade 2.3.4.4 pose a public health threat but the viral factors relevant for its potential adaptation to mammals are largely unknown.
Claudia Blaurock, Ulrike Blohm, Christine Luttermann, Julia Holzerland, David Scheibner, Alexander Schäfer, Allison Groseth, Thomas C. Mettenleiter, Elsayed M. Abdelwhab   +8 more
doaj   +1 more source