Results 1 to 10 of about 2,328 (129)

Impact of Individual Viral Gene Segments from Influenza A/H5N8 Virus on the Protective Efficacy of Inactivated Subtype-Specific Influenza Vaccine

Pathogens, 2021
Since its emergence in 2014, the highly pathogenic avian influenza H5N8 virus has continuously and rapidly spread worldwide in the poultry sector resulting in huge economic losses.
Ahmed Moustafa Mohamed Elsayed, Maha AlKhazindar, Ghazi Kayali   +2 more
exaly   +3 more sources

Novel Clade 2.3.4.4b Highly Pathogenic Avian Influenza A H5N8 and H5N5 Viruses in Denmark, 2020

Viruses, 2021
Since late 2020, outbreaks of H5 highly pathogenic avian influenza (HPAI) viruses belonging to clade 2.3.4.4b have emerged in Europe. To investigate the evolutionary history of these viruses, we performed genetic characterization on the first HPAI ...
Charlotte Kristiane Hjulsager, Lars Erik Larsen, Ramona Trebbien   +2 more
exaly   +3 more sources

Nomenclature Updates to the Hemagglutinin Gene Clade Designations Resulting From the Continued Evolution of High Pathogenicity Avian Influenza A(H5) Virus Clades 2.3.2.1c and 2.3.4.4 [PDF]

Influenza Other Respir Viruses
ABSTRACT Background and Methods The evolutionary divergence of the A(H5) hemagglutinin (HA) gene of high pathogenicity avian influenza (HPAI) viruses (A/goose/Guangdong/96 lineage) was analyzed by phylogenetic and average pairwise distance methods to identify clades that merit nomenclature updates.
Lam T, Davis C, Bonfante F, Brown I, Carnegie L, Coggon A, Davis C, Fusaro A, Fouchier R, Guan Y, Hasegawa H, Jang Y, Karlsson E, Kim‐Torchetti M, Lam T, Lewis N, Monne I, Pavade G, Samaan M, Shepard S, Suarez D, Wang D, Webby R, Wong F, Zhang W.   +24 more
europepmc   +2 more sources

Comparative Virological and Pathogenic Characteristics of Avian Influenza H5N8 Viruses Detected in Wild Birds and Domestic Poultry in Egypt during the Winter of 2016/2017

Viruses, 2019
The surveillance and virological characterization of H5N8 avian influenza viruses are important in order to assess their zoonotic potential. The genetic analyses of the Egyptian H5N8 viruses isolated through active surveillance in wild birds and domestic
Basma Emad Aboulhoda, Ahmed Moustafa Mohamed Elsayed, Maha AlKhazindar   +2 more
exaly   +3 more sources

Serological Surveillance of Avian Influenza Virus Exposure Using Paired Sera Among Occupational Contacts in Taiwan, January-September 2025. [PDF]

Influenza Other Respir Viruses
ABSTRACT In 2025, Taiwan implemented paired sera surveillance among occupational contacts of avian influenza viruses (AIVs). Of 122 contacts analyzed, 117 (95.9%) remained asymptomatic with high personal protective equipment compliance (91.8%). No seroconversion was detected against AIV A(H5N2) clade 2.3.4.4b. These findings suggest a low risk of human
Lin CY, Tsou TP, Chu PW, Yang SE, Yu IL, Li YT, Liu MT, Chih YC.   +7 more
europepmc   +2 more sources

A Monoclonal Antibody ELISA-Based Assay for Measuring the Potency of Candidate H5 Clade 2.3.4.4b Pandemic Influenza Vaccines. [PDF]

Influenza Other Respir Viruses
ABSTRACT Background The single radial immunodiffusion (SRID) assay is used to determine the potency of inactivated influenza vaccines. Nevertheless, development of alternative influenza vaccine potency assays with greater sensitivity and less reliance on large quantities of reference reagents is needed.
Odin M, Schmeisser F, Soto J, Weir JP.
europepmc   +2 more sources

Immunogenic and Protective Properties of Recombinant Hemagglutinin of Influenza A (H5N8) Virus

Vaccines
In this study, we characterized recombinant hemagglutinin (HA) of influenza A (H5N8) virus produced in Chinese hamster ovary cells (CHO-K1s). Immunochemical analysis showed that the recombinant hemagglutinin was recognized by the serum of ferrets ...
Dmitry Shcherbakov, Mariya Borgoyakova, Vasiliy Y Marchenko   +2 more
exaly   +3 more sources

AddaVax-Adjuvanted H5N8 Inactivated Vaccine Induces Robust Humoral Immune Response against Different Clades of H5 Viruses

Vaccines, 2022
Since some cases of human infections with H5N8 avian influenza virus have been reported and caused great concern in recent years, it is important to develop an effective vaccine for human use to prevent a potential H5N8 pandemic.
Xiuling Li, Feixia Gao
exaly   +3 more sources

Genetic and Antigenic Characteristics of Highly Pathogenic Avian Influenza A(H5N8) Viruses Circulating in Domestic Poultry in Egypt, 2017–2021

Microorganisms, 2022
In Egypt, the endemicity of avian influenza viruses is a serious concern. Since 2016, several outbreaks of H5N8 have been recorded among domestic poultry in various areas of the country. Active surveillance of domestic poultry across several governorates
Richard Webby, Ghazi Kayali, Mohamed A. Ali   +2 more
exaly   +3 more sources

Emergence of Novel Highly Pathogenic Avian Influenza Virus A(H5N1) Clade 2.3.4.4b in Commercial Poultry, Bangladesh. [PDF]

Influenza Other Respir Viruses
ABSTRACT Background The high‐pathogenicity avian influenza (HPAI) viruses represent a main threat to animal and human health, poultry productivity, and ecosystems. The newly evolved A(H5N1) clade 2.3.4.4b has become a worldwide concern for its expanding multihost ecology, including poultry and a wide range of mammalian species.
Samad MA, Karim MR, Coggon A, Hossen A, Uddin ASMA, Hossain MG, Fournie G, Lewis NS, Byrne AMP.   +8 more
europepmc   +2 more sources