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Immunogenic and Protective Properties of Recombinant Hemagglutinin of Influenza A (H5N8) Virus
VaccinesIn this study, we characterized recombinant hemagglutinin (HA) of influenza A (H5N8) virus produced in Chinese hamster ovary cells (CHO-K1s). Immunochemical analysis showed that the recombinant hemagglutinin was recognized by the serum of ferrets ...
Dmitry Shcherbakov +2 more
exaly +5 more sources
Construction and Immune Strategy Optimization of a Vaccine Strain for Influenza A (H5N8) Subtype [PDF]
VirusesMultiple subtypes of avian influenza virus (AIV), including H5N1, H5N6, and H5N8 viruses, are currently co-circulating in wild birds and poultry and causing sporadic human infections. Vaccine development is essential for pandemic preparedness.
Shuxia Zhang +14 more
doaj +4 more sources
Pathogens, 2021 Since its emergence in 2014, the highly pathogenic avian influenza H5N8 virus has continuously and rapidly spread worldwide in the poultry sector resulting in huge economic losses.
Ahmed Moustafa Mohamed Elsayed +2 more
exaly +3 more sources
Frontiers in Microbiology, 2022 Highly pathogenic influenza A(H5N8) viruses had caused several outbreaks among wild bird and poultry populations across the globe, and strikingly, caused human infection, posing serious public health concerns.
Jiahao Zhang
exaly +3 more sources
Novel HPAIV H5N8 Reassortant (Clade 2.3.4.4b) Detected in Germany [PDF]
Viruses, 2020 A novel H5N8 highly pathogenic avian influenza virus (HPAIV) was detected in a greater white-fronted goose in January 2020 in Brandenburg, Germany, and, in February 2020, in domestic chickens belonging to a smallholding in Baden-Wuerttemberg, Germany ...
Jacqueline King +11 more
doaj +3 more sources
A Monoclonal Antibody ELISA-Based Assay for Measuring the Potency of Candidate H5 Clade 2.3.4.4b Pandemic Influenza Vaccines. [PDF]
Influenza Other Respir VirusesABSTRACT Background The single radial immunodiffusion (SRID) assay is used to determine the potency of inactivated influenza vaccines. Nevertheless, development of alternative influenza vaccine potency assays with greater sensitivity and less reliance on large quantities of reference reagents is needed.
Odin M, Schmeisser F, Soto J, Weir JP.
europepmc +2 more sources
Peering into Avian Influenza A(H5N8) for a Framework towards Pandemic Preparedness [PDF]
Viruses, 2021 2014 marked the first emergence of avian influenza A(H5N8) in Jeonbuk Province, South Korea, which then quickly spread worldwide. In the midst of the 2020–2021 H5N8 outbreak, it spread to domestic poultry and wild waterfowl shorebirds, leading to the ...
Joshua Yi Yeo, Samuel Ken-En Gan
doaj +4 more sources
Global review of the H5N8 avian influenza virus subtype
Frontiers in Microbiology, 2023 Orthomyxoviruses are negative-sense, RNA viruses with segmented genomes that are highly unstable due to reassortment. The highly pathogenic avian influenza (HPAI) subtype H5N8 emerged in wild birds in China.
Saba Rafique +15 more
doaj +3 more sources
Novel Clade 2.3.4.4b Highly Pathogenic Avian Influenza A H5N8 and H5N5 Viruses in Denmark, 2020
Viruses, 2021 Since late 2020, outbreaks of H5 highly pathogenic avian influenza (HPAI) viruses belonging to clade 2.3.4.4b have emerged in Europe. To investigate the evolutionary history of these viruses, we performed genetic characterization on the first HPAI ...
Charlotte Kristiane Hjulsager +2 more
exaly +3 more sources
Highly Pathogenic Avian Influenza A(H5N8) Virus in Swans, China, 2020 [PDF]
Emerging Infectious Diseases, 2021 In October 2020, highly pathogenic avian influenza A(H5N8) viruses were detected in 2 dead swans in Inner Mongolia, China. Genetic analysis showed that the H5N8 isolates belong to clade 2.3.4.4b and that the isolates cluster with the H5N8 viruses ...
Xiang Li +19 more
doaj +3 more sources