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Novel Clade 2.3.4.4b Highly Pathogenic Avian Influenza A H5N8 and H5N5 Viruses in Denmark, 2020

Viruses, 2021
Since late 2020, outbreaks of H5 highly pathogenic avian influenza (HPAI) viruses belonging to clade 2.3.4.4b have emerged in Europe. To investigate the evolutionary history of these viruses, we performed genetic characterization on the first HPAI ...
Yuan Liang, Jakob N. Nissen, Jesper S. Krog, Solvej Ø. Breum, Ramona Trebbien, Lars E. Larsen, Charlotte K. Hjulsager   +6 more
doaj   +3 more sources

Infections with highly pathogenic avian influenza A virus (HPAIV) H5N8 in harbor seals at the German North Sea coast, 2021

Emerging Microbes and Infections, 2022
In brain tissue of three harbor seals of the German North Sea Coast, high virus loads of highly pathogenic avian influenza virus (HPAIV) H5N8 were detected.
Alexander Postel, Jacqueline King, Franziska K. Kaiser, Johanna Kennedy, Mara Sophie Lombardo, Wencke Reineking, Madeleine de le Roi, Timm Harder, Anne Pohlmann, Thomas Gerlach, Guus Rimmelzwaan, Simon Rohner, Lotte Caecilia Striewe, Stephanie Gross, Luca A. Schick, Jana C. Klink, Katharina Kramer, Albert D. M. E. Osterhaus, Martin Beer, Wolfgang Baumgärtner, Ursula Siebert, Paul Becher   +21 more
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Comparative Virological and Pathogenic Characteristics of Avian Influenza H5N8 Viruses Detected in Wild Birds and Domestic Poultry in Egypt during the Winter of 2016/2017

Viruses, 2019
The surveillance and virological characterization of H5N8 avian influenza viruses are important in order to assess their zoonotic potential. The genetic analyses of the Egyptian H5N8 viruses isolated through active surveillance in wild birds and domestic
Yassmin Moatasim, Ahmed Kandeil, Basma Emad Aboulhoda, Rabeh El-Shesheny, Maha Alkhazindar, Elsayed Tarek AbdElSalam, Omnia Kutkat, Mina Nabil Kamel, Ahmed Nageh El Taweel, Ahmed Mostafa, Joseph T. Hicks, Sary Khaleel Abd elghaffar, Ghazi Kayali, Mohamed Ahmed Ali   +13 more
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Novel HPAIV H5N8 Reassortant (Clade 2.3.4.4b) Detected in Germany

Viruses, 2020
A novel H5N8 highly pathogenic avian influenza virus (HPAIV) was detected in a greater white-fronted goose in January 2020 in Brandenburg, Germany, and, in February 2020, in domestic chickens belonging to a smallholding in Baden-Wuerttemberg, Germany ...
Jacqueline King, Christoph Schulze, Andreas Engelhardt, Andreas Hlinak, Sara-Lisa Lennermann, Kerstin Rigbers, Jasmin Skuballa, Christoph Staubach, Thomas C. Mettenleiter, Timm Harder, Martin Beer, Anne Pohlmann   +11 more
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Genetic and Antigenic Characteristics of Highly Pathogenic Avian Influenza A(H5N8) Viruses Circulating in Domestic Poultry in Egypt, 2017–2021

Microorganisms, 2022
In Egypt, the endemicity of avian influenza viruses is a serious concern. Since 2016, several outbreaks of H5N8 have been recorded among domestic poultry in various areas of the country. Active surveillance of domestic poultry across several governorates
Ahmed Kandeil, Yassmin Moatasim, Ahmed El Taweel, Mohamed El Sayes, Adam Rubrum, Trushar Jeevan, Pamela P. McKenzie, Richard J. Webby, Mohamed A. Ali, Ghazi Kayali, Rabeh El-Shesheny   +10 more
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Emergence, prevalence, and evolution of H5N8 avian influenza viruses in central China, 2020

Emerging Microbes and Infections, 2022
Highly pathogenic influenza A(H5N8) viruses have caused several worldwide outbreaks in birds and are able cross the species barrier to infect humans, posing a substantial threat to public health.
Xiang Li, Xinru Lv, Yi Li, Linhong Xie, Peng Peng, Qing An, Tian Fu, Siyuan Qin, Yuan Cui, Chengbo Zhang, Rongxiu Qin, Fengyi Qu, Zhenliang Zhao, Meixi Wang, Qiuzi Xu, Yong Li, Guoxiang Yang, Guang Chen, Jun Zhang, Hesong Zheng, Enda Ma, Ruifang Zhou, Xiangwei Zeng, Yulong Wang, Zhijun Hou, Yajun Wang, Dong Chu, Yanbing Li, Hongliang Chai   +28 more
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Complex Evolutionary Dynamics of H5N8 Influenza A Viruses Revealed by Comprehensive Reassortment Analysis [PDF]

Viruses
Influenza A viruses (IAVs) circulate among different species and have the potential to cause significant pandemics in humans. This study focuses on reassortment events in the H5N8 subtype of IAV, which poses a serious threat to public health due to its ...
Egor Degtyarev, Sofia Feoktistova, Pavel Volchkov, Andrey Deviatkin   +3 more
doaj   +2 more sources

Construction and Immune Strategy Optimization of a Vaccine Strain for Influenza A (H5N8) Subtype [PDF]

Viruses
Multiple subtypes of avian influenza virus (AIV), including H5N1, H5N6, and H5N8 viruses, are currently co-circulating in wild birds and poultry and causing sporadic human infections. Vaccine development is essential for pandemic preparedness.
Shuxia Zhang, Jing Tang, Liqi Liu, Hejiang Wei, Li Xin, Kang Xiao, Jinbo Xiao, Jie Dong, Zi Li, Hongyan Bai, Shuaixing Wang, Wenfei Zhu, Lei Yang, Shumei Zou, Dayan Wang   +14 more
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Lack of virological and serological evidence for continued circulation of highly pathogenic avian influenza H5N8 virus in wild birds in the Netherlands, 14 November 2014 to 31 January 2016 [PDF]

, 2016
In 2014, H5N8 clade 2.3.4.4 highly pathogenic avian influenza (HPAI) viruses of the A/Goose/ Guangdong/1/1996 lineage emerged in poultry and wild birds in Asia, Europe and North America.
Bestebroer, T.M. (Theo), Brown, I.H. (Ian), Fouchier, R.A.M. (Ron), Grund, C., Kleyheeg, E. (Erik), Majoor, F. (Frank), Manvell, R.J., Müskens, G.J.D.M., Nolet, B.A. (Bart), Poen, M.J. (Marjolein), Scheuer, R.D., van der Jeugd, H.P., Verhagen, J.H. (Josanne), Vliet, S. (Stefan) van der, Vuong, O. (Oanh)   +14 more
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Impact of Individual Viral Gene Segments from Influenza A/H5N8 Virus on the Protective Efficacy of Inactivated Subtype-Specific Influenza Vaccine

Pathogens, 2021
Since its emergence in 2014, the highly pathogenic avian influenza H5N8 virus has continuously and rapidly spread worldwide in the poultry sector resulting in huge economic losses.
Yassmin Moatasim, Ahmed Kandeil, Ahmed Mostafa, Omnia Kutkat, Mohamed El Sayes, Ahmed N. El Taweel, Maha AlKhazindar, Elsayed T. AbdElSalam, Rabeh El-Shesheny, Ghazi Kayali, Mohamed A. Ali   +10 more
doaj   +1 more source