Results 131 to 140 of about 3,090 (189)

Human protein synthesis requires aminoacyl-tRNA pivoting during proofreading. [PDF]

Nat Commun
Sapkota D, Sanbonmatsu KY, Girodat D.
europepmc   +1 more source

Multifaceted roles of mycobacterial HflX: ribosome splitting, rRNA disordering, and drug resistance. [PDF]

Biochem Soc Trans
Majumdar S, Ghosh P, Agrawal RK.
europepmc   +1 more source

Epichaperomes: redefining chaperone biology and therapeutic strategies in complex diseases. [PDF]

RSC Chem Biol
Pasala C, Digwal CS, Sharma S, Wang S, Bubula A, Chiosis G.   +5 more
europepmc   +1 more source

PU-H71 a novel Hsp90 inhibitor as a potential cancer-specific sensitizer to carbon-ion beam therapy

PU-H71 a novel Hsp90 inhibitor as a potential cancer-specific sensitizer to carbon-ion beam therapy
PU-H71, a Heat shock protein 90 (Hsp90) inhibitor, has yielded therapeutic efficacy in many preclinical models and is currently in clinical trials. Carbon-ion radiotherapy (CIRT) has provided successful tumor control; however, there is still a room for improvement, particularly in terms of tumor-specific radiosensitization.
openaire   +1 more source

Overcoming cancer drug resistance through small-molecule targeting of HSP90 and HSP70. [PDF]

Cancer Drug Resist
Cai RD, Lin MJ, Ye QM.
europepmc   +1 more source

PTMs as molecular encoders: reprogramming chaperones into epichaperomes for network control in disease. [PDF]

Trends Biochem Sci
Chu F, Sharma S, Ginsberg SD, Chiosis G.
europepmc   +1 more source

Unravelling Rational Design of Molecularly Imprinted Polymer for Selective Mitragynine Isolation from Kratom: Quantum Mechanical, Molecular Dynamics, and Experimental Insights. [PDF]

Molecules
Gunawan U, Prasetyanto EA, Kambira PFA, Notario D, Wulandari E, Istyastono EP, Wening AT, Irlianto K, Ivansyah AL.   +8 more
europepmc   +1 more source

Co-targeting HSP90 alpha and CDK7 overcomes resistance against HSP90 inhibitors in BCR-ABL1+ leukemia cells. [PDF]

Cell Death Dis, 2023
Vogt M, Dienstbier N, Schliehe-Diecks J, Scharov K, Tu JW, Gebing P, Hogenkamp J, Bilen BS, Furlan S, Picard D, Remke M, Yasin L, Bickel D, Kalia M, Iacoangeli A, Lenz T, Stühler K, Pandyra AA, Hauer J, Fischer U, Wagener R, Borkhardt A, Bhatia S.   +22 more
europepmc   +1 more source

The Role of Radiosensitizing Drugs in Osteosarcoma Treatment: Mechanisms and Clinical Perspectives. [PDF]

Drug Des Devel Ther
Zhang Y, Xie Y, Wang Y, Huang P, Lu Y.
europepmc   +1 more source

Identification of a ligand-binding site on tubulin mediating the tubulin-RB3 interaction. [PDF]

Proc Natl Acad Sci U S A
Li Y, Zhang C, Tang D, Wang T, Yan W, Yang L, Bai P, Tang M, Pei H, Chen L, Chen Q, Yang J.   +11 more
europepmc   +1 more source