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Efficient Infectious Cell Culture Systems of the Hepatitis C Virus (HCV) Prototype Strains HCV-1 and H77 [PDF]
Journal of Virology, 2015 ABSTRACT The first discovered and sequenced hepatitis C virus (HCV) genome and the first in vivo infectious HCV clones originated from the HCV prototype strains HCV-1 and H77, respectively, both widely used in research of this important human pathogen.
Yiping Li +2 more
exaly +5 more sources
The stability of secreted, acid-labile H77/JFH-1 hepatitis C virus (HCV) particles is altered by patient isolate genotype 1a p7 sequences [PDF]
Virology, 2014 Secreted infectious particles generated by the genotype 2a JFH-1 hepatitis C virus infectious clone are resistant to acidic pH, whereas intracellular virions remain acid-labile. Thus, JFH-1 particles are thought to undergo pH maturation as they are secreted from the cell. Here, we demonstrate that both infectious intracellular and secreted genotype 1a (
Elizabeth Atkins, Ranjitha Tathineni
exaly +5 more sources
Native-like soluble E1E2 glycoprotein heterodimers on self-assembling protein nanoparticles for hepatitis C virus vaccine design [PDF]
Nature CommunicationsHepatitis C virus (HCV) is a leading cause of chronic liver disease, cirrhosis, and hepatocellular carcinoma worldwide. Development of an E1E2-based HCV vaccine has been hindered by the difficulty of producing a soluble E1E2 (sE1E2) antigen that ...
Linling He +17 more
doaj +2 more sources
“Influence of plasmids, selection markers and auxotrophic mutations on Haloferax volcanii cell shape plasticity” [PDF]
Frontiers in Microbiology, 2023 Haloferax volcanii and other Haloarchaea can be pleomorphic, adopting different shapes, which vary with growth stages. Several studies have shown that H.
Megha Patro +4 more
doaj +2 more sources
Spatial interactions in local public debt. Evidence from Poland
Economics and Business Review, 2023 The aim of the paper is to investigate spatial interactions among the debt of 2,442 municipalities in Poland over the period 2005–2020. Using the dynamic spatial Durbin model with two-way fixed effects, it provides empirical evidence of positive spatial ...
Banaszewska Monika
doaj +1 more source
UNDERSTANDING INTRA-HOUSEHOLD EXPENDITURE DISTRIBUTION IN INDONESIA
Economic Journal of Emerging Markets, 2014 Decentralisation provides regional government with greater authority to deliver various public services. It is expected that decentralisation will improve people welfare due to proximity. This study is aimed to investigate whether there is improvement in
Heru Wibowo
doaj +9 more sources
Acta Universitatis Sapientiae: Economics and Business, 2023 This study tries to empirically estimate the effects of the composition of intergovernmental transfers on tax collection across the Indian states by using panel regression model.
Kumar Sumit, Kaur Baljit
doaj +1 more source
Assessment of the European Commission's proposals for financing the EU budget in 2021–20271
International Journal of Management and Economics, 2020 A major problem in all European Union (EU) budgetary negotiations is the approach of Member States in net return terms (the fair-return approach). EU members compare their contributions to the EU budget with transfers that they receive from the budget ...
Kawecka-Wyrzykowska Elżbieta
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Genotype 1a HCV (H77S) Infection System
PLoS ONE, 2009 HCV is a small RNA virus belonging to the genus Hepacivirus within the virus family Flaviviridae. Infection with HCV often leads to chronic liver diseases including chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. Current therapy, based on the use of interferon-alpha (IFN-alpha) in combination with ribavirin, results in limited success,
Minkyung, Yi, Stanley M, Lemon
openaire +8 more sources
PLoS Pathogens, 2021 Hepatitis C virus (HCV) chronically infects 70 million people worldwide with an estimated annual disease-related mortality of 400,000. A vaccine could prevent spread of this pervasive human pathogen, but has proven difficult to develop, partly due to ...
Christina Holmboe Olesen +4 more
doaj +1 more source