Native-like soluble E1E2 glycoprotein heterodimers on self-assembling protein nanoparticles for hepatitis C virus vaccine design [PDF]
Nature CommunicationsHepatitis C virus (HCV) is a leading cause of chronic liver disease, cirrhosis, and hepatocellular carcinoma worldwide. Development of an E1E2-based HCV vaccine has been hindered by the difficulty of producing a soluble E1E2 (sE1E2) antigen that ...
Linling He +17 more
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Efficient Infectious Cell Culture Systems of the Hepatitis C Virus (HCV) Prototype Strains HCV-1 and H77 [PDF]
Journal of Virology, 2015 ABSTRACT The first discovered and sequenced hepatitis C virus (HCV) genome and the first in vivo infectious HCV clones originated from the HCV prototype strains HCV-1 and H77, respectively, both widely used in research of this important human pathogen.
Yiping Li +2 more
exaly +4 more sources
“Influence of plasmids, selection markers and auxotrophic mutations on Haloferax volcanii cell shape plasticity” [PDF]
Frontiers in Microbiology, 2023 Haloferax volcanii and other Haloarchaea can be pleomorphic, adopting different shapes, which vary with growth stages. Several studies have shown that H.
Megha Patro +4 more
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Virology, 2014 Secreted infectious particles generated by the genotype 2a JFH-1 hepatitis C virus infectious clone are resistant to acidic pH, whereas intracellular virions remain acid-labile. Thus, JFH-1 particles are thought to undergo pH maturation as they are secreted from the cell. Here, we demonstrate that both infectious intracellular and secreted genotype 1a (
Ranjitha Tatineni +2 more
exaly +4 more sources
UNDERSTANDING INTRA-HOUSEHOLD EXPENDITURE DISTRIBUTION IN INDONESIA
Economic Journal of Emerging Markets, 2014 Decentralisation provides regional government with greater authority to deliver various public services. It is expected that decentralisation will improve people welfare due to proximity. This study is aimed to investigate whether there is improvement in
Heru Wibowo
doaj +9 more sources
Acta Universitatis Sapientiae: Economics and Business, 2023 This study tries to empirically estimate the effects of the composition of intergovernmental transfers on tax collection across the Indian states by using panel regression model.
Kumar Sumit, Kaur Baljit
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Spatial interactions in local public debt. Evidence from Poland
Economics and Business Review, 2023 The aim of the paper is to investigate spatial interactions among the debt of 2,442 municipalities in Poland over the period 2005–2020. Using the dynamic spatial Durbin model with two-way fixed effects, it provides empirical evidence of positive spatial ...
Banaszewska Monika
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Genotype 1a HCV (H77S) Infection System
PLoS ONE, 2009 HCV is a small RNA virus belonging to the genus Hepacivirus within the virus family Flaviviridae. Infection with HCV often leads to chronic liver diseases including chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. Current therapy, based on the use of interferon-alpha (IFN-alpha) in combination with ribavirin, results in limited success,
Minkyung, Yi, Stanley M, Lemon
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Evolution of a Cell Culture-Derived Genotype 1a Hepatitis C Virus (H77S.2) during Persistent Infection with Chronic Hepatitis in a Chimpanzee [PDF]
Journal of Virology, 2014 ABSTRACT Persistent infection is a key feature of hepatitis C virus (HCV). However, chimpanzee infections with cell culture-derived viruses (JFH1 or related chimeric viruses that replicate efficiently in cell culture) have been limited to acute-transient infections with no pathogenicity.
MinKyung, Yi +14 more
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Mutational analysis of the hepatitis C virus E1 glycoprotein in retroviral pseudoparticles and cell‐culture‐derived H77/JFH1 chimeric infectious virus particles [PDF]
Journal of Viral Hepatitis, 2009 Summary. Cell entry by enveloped viruses is mediated by viral glycoproteins, and generally involves a short hydrophobic peptide (fusion peptide) that inserts into the cellular membrane. An internal hydrophobic domain within E1 (aa262–290) of hepatitis C virus (HCV) may function as a fusion peptide.
Russell, R S +7 more
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