HSP90 Inhibitor PU-H71 in Combination with BH3-Mimetics in the Treatment of Acute Myeloid Leukemia [PDF]
Current Issues in Molecular Biology, 2023 Targeting the molecular chaperone HSP90 and the anti-apoptotic proteins MCL1 and BCL2 may be a promising novel approach in the treatment of acute myeloid leukemia (AML).
Ulrike Bacher +2 more
exaly +4 more sources
PU-H71 (NSC 750424): a molecular masterpiece that targets HSP90 in cancer and beyond [PDF]
Frontiers in PharmacologyHeat shock protein 90 (HSP90) is a pivotal molecular chaperone with multifaceted roles in cellular health and disease. Herein, we explore how HSP90 orchestrates cellular stress responses, particularly through its partnership with heat shock factor 1 (HSF-
Sameh Saber +16 more
doaj +2 more sources
Journal of Hematology and Oncology, 2010 Background Heat shock protein 90 (HSP90) inhibitors have emerged as a promising class of anti-cancer drugs in both solid and hematologic malignancies.
Saad Z Usmani +2 more
exaly +3 more sources
FLT3 and IRAK4 Inhibitor Emavusertib in Combination with BH3-Mimetics in the Treatment of Acute Myeloid Leukemia [PDF]
Current Issues in Molecular BiologyTargeting the FLT3 receptor and the IL-1R associated kinase 4 as well as the anti-apoptotic proteins MCL1 and BCL2 may be a promising novel approach in the treatment of acute myeloid leukemia (AML).
Katja Seipel +3 more
doaj +2 more sources
Synthesis and evaluation of cell-permeable biotinylated PU-H71 derivatives as tumor Hsp90 probes
Beilstein Journal of Organic Chemistry, 2013 The attachment of biotin to a small molecule provides a powerful tool in biology. Here, we present a systematic approach to identify biotinylated analogues of the Hsp90 inhibitor PU-H71 that are capable of permeating cell membranes so as to enable the ...
Gabriela Chiosis +2 more
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Epichaperome Inhibition by PU-H71-Mediated Targeting of HSP90 Sensitizes Glioblastoma Cells to Alkylator-Induced DNA Damage [PDF]
CancersPratibha Sharma +2 more
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A Rare Paraspinal Desmoid Tumour following Instrumented Scoliosis Correction in an Adolescent
Case Reports in Orthopedics, 2021 Desmoid tumours are benign neoplasms of myofibroblasts, often occurring after soft-tissue trauma. Rarely, desmoid tumours can occur following operative intervention, including spine surgery.
Fergus J. McCabe +2 more
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A purine analog synergizes with chloroquine (CQ) by targeting Plasmodium falciparum Hsp90 (PfHsp90). [PDF]
PLoS ONE, 2013 Drug resistance, absence of an effective vaccine, and inadequate public health measures are major impediments to controlling Plasmodium falciparum malaria worldwide. The development of antimalarials to which resistance is less likely is paramount.
Dea Shahinas +5 more
doaj +1 more source
Measuring the pharmacodynamic effects of a novel Hsp90 inhibitor on HER2/neu expression in mice using Zr-DFO-trastuzumab. [PDF]
PLoS ONE, 2010 The positron-emitting radionuclide (89)Zr (t(1/2) = 3.17 days) was used to prepare (89)Zr-radiolabeled trastuzumab for use as a radiotracer for characterizing HER2/neu-positive breast tumors.
Jason P Holland +7 more
doaj +1 more source
Cells, 2021 In Section 4.1.3 of the published paper, the authors made an incorrect and unsupported statement regarding PU-H71 and a Samus-sponsored Phase 1 clinical trial [...]
Ji Woong Kim, Yea Bin Cho, Sukmook Lee
doaj +1 more source