Results 11 to 20 of about 3,267 (182)

In Vitro Purging of Acute Lymphoblastic Leukemia (B-ALL) Cells with the Use of PTL, DMAPT, or PU-H71. [PDF]

Int J Mol Sci
Acute lymphoblastic leukemia (ALL) is a hematopoietic disorder that mainly affects the child population, and it is characterized by the presence of lymphoid progenitor or precursor cells with different genetic alterations.
Ortiz-Reyes AE, García-Sánchez S, Serrano M, Núñez-Enriquez JC, Alvarado-Moreno JA, Montesinos JJ, Fajardo-Orduña G, Guzman ML, Villasis-Keever MA, Mancilla-Herrera I, Mayani H, Chavez-Gonzalez A.   +11 more
europepmc   +4 more sources

Radiosensitization of human lung cancer cells by the novel purine-scaffold Hsp90 inhibitor, PU-H71.

International Journal of Molecular Medicine, 2013
The molecular chaperone heat shock protein 90 (Hsp90) is involved in the maturation and stabilization of a wide range of oncogenic client proteins for oncogenesis and malignant cell proliferation, which renders this protein a promising target in the ...
Segawa, Tatsuya, Bando, Shin-Ichi, 468407, Tanaka, Aya, 468406, Fujii, Yoshihiro, 468405, 岡安 隆一, 468404, 468403, 468402, 468401, 468400, Ohnishi, Ken, Okayasu, Ryuichi, Kubota, Nobuo   +15 more
core   +5 more sources

Mutation of Framework Residue H71 Results in Different Antibody Paratope States in Solution [PDF]

Frontiers in Immunology, 2021
Characterizing and understanding the antibody binding interface have become a pre-requisite for rational antibody design and engineering. The antigen-binding site is formed by six hypervariable loops, known as the complementarity determining regions ...
Monica L. Fernández-Quintero, Katharina B. Kroell, Florian Hofer, Jakob R. Riccabona, Klaus R. Liedl   +4 more
doaj   +3 more sources

HSP90 stabilizes B-cell receptor kinases in a multi-client interactome: PU-H71 induces CLL apoptosis in a cytoprotective microenvironment [PDF]

Oncogene, 2017
Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of B cells in the hematopoietic system and lymphoid tissues. Although inhibitors targeting the B-cell receptor (BCR) pathway have been successful in the treatment of the disease, the
Zhen, C, Lee, J, Guo, A, Lu, P, Wang, YL, Chiosis, G   +5 more
core   +7 more sources

Abstract 5766: The Hsp90 inhibitor PU-H71 is a potent suppressor of metastasis in triple-negative breast cancer models

Cancer Research, 2010
Background: Triple-negative breast cancer (TNBC) characterized by estrogen and progesterone receptor and HER-2-negativity is a particularly aggressive tumor with currently no effective targeted therapies.
Paula Bos, Leandro Cerchietti, Ari Melnick, Hector Peinado, Eloisi Caldas Lopes, Simon Lavotshkin, Gabriela Chiosis, David Lyden   +7 more
core   +2 more sources

HSP90 inhibitörü PU-H71’in ve radyoterapi ile kombine uygulamasının metastatik meme kanseri üzerine etkisinin araştırılması [PDF]

, 2016
HSP90 (Isı Şok Proteini 90) birçok hücresel proteinin stabilizasyonunu sağlamaktadır. Stresli durumlarda ekspresyonu artan HSP90 hücresel proteinleri degredasyondan korur. HSP90'nın ekspresyon profili normal ve malign hücrelerde farklılık göstermektedir.
Kale, Şule
core   +3 more sources

Hsp90 Inhibitor PU-H71 [PDF]

, 2020

core   +2 more sources

Epichaperome-targeted myocardial imaging by ¹²⁴I-PU-H71 PET. [PDF]

Clin Transl Imaging, 2023
Abstract Background 124I-PU-H71 is an imaging biomarker of epichaperome formation, localizing in tissues under chronic stress. A first-in-human positron emission tomography (PET) trial in cancer patients revealed unexpected tracer accumulation in the myocardium.
Mahajan S, Grkovski M, Staton KD, Ravassa S, Domfe K, Strauss HW, Humm JL, Zanzonico PB, Beattie BJ, Cho I, Burnazi EM, Fox JJ, Schöder H, Osborne JR, Youn T, Jhaveri K, Chiosis G, Dunphy MP.   +17 more
europepmc   +3 more sources

Fiscal Federalism, Tax Independence and Social Enhancement

Studia Universitatis Vasile Goldis Arad, Seria Stiinte Economice, 2022
The tax autonomy of Nigeria’s three tiers of government is examined in this study to estimate the value of revenue fiscal decentralization in increasing citizens’ social welfare.
Omodero Cordelia Onyinyechi
doaj   +1 more source

Stimuli contributing to local property taxation – with the focus on spatial effects of industry and functional urban areas

Central European Journal of Public Policy, 2021
In this study, we argue that a historical background of the region matters in tax mimicking and yardstick competition as a matter of principle. We seek to determine factors supporting the policy of the high local property tax in the Czech Republic. Based
Zdražil Pavel, Pernica Bohuslav
doaj   +1 more source