Results 181 to 189 of about 3,090 (189)

Abstract 2752: Novel inhibitor of HSP90- PU-H71 exhibits significant activity in Ewing sarcoma pre-clinical models.

Cancer Research, 2013
Abstract Ewing sarcoma is characterized by multiple deregulated pathways that mediate cell survival and proliferation. Heat shock protein-90 (HSP90) is a critical component of the multi-chaperone complexes that regulate the disposition and activity of a large number of proteins responsible for the assembly and regulation of cell ...
Srikanth R. Ambati, Eloisi Caldas Lopes, Ullas Mony, Kohji Kosugi, Andre Moreira, Paul Meyers, Gabriela Chiosis, Malcolm Moore   +7 more
openaire   +1 more source

FLT3-ITD+ AML Blast, Progenitor and Stem Cell Populations Demonstrate Higher Sensitivity to the Hsp90 Inhibitor PU-H71,

Blood, 2011
Abstract Abstract 3500 Hsp90, one of the best-characterized molecular chaperones, plays indispensable roles in folding and assembly, intracellular transport, stabilization, and degradation of proteins, and therefore, facilitating cell signaling.
Hongliang Zong, Tony Taldone, James H. Ahn, Sarah Brennan, Jeanne P. De Leon, Michael W. Becker, Gail J. Roboz, Gabriela Chiosis, Monica L. Guzman   +8 more
openaire   +1 more source

Pre‐clinical efficacy of PU‐H71, a novel HSP90 inhibitor, alone and in combination with bortezomib in Ewing sarcoma

Molecular Oncology, 2014
Srikanth R Ambati, Eloisi Caldas Lopes, Ullas Mony   +2 more
exaly  

Assess the Safety, Tolerability Oral PU-H71 in Subjects Taking Ruxolitinib

Case Medical Research, 2019
openaire   +1 more source

A facile and efficient synthesis of d6‐labeled PU‐H71, a purine‐scaffold Hsp90 inhibitor

Journal of Labelled Compounds and Radiopharmaceuticals, 2010
Tony Taldone, Danuta Zatorska, Yanlong Kang   +2 more
exaly  

The Preparation and Properties of Ammonia-Triborane, H3NB3H71

Journal of the American Chemical Society, 1959
R W Parry
exaly  

601 The Antimyeloma Activity of PU-H71, a Novel Purine Scaffold HSP90 Inhibitor, is via Inhibition of Both HSP90A and HSP90B1

Clinical Lymphoma Myeloma and Leukemia, 2011
Saad Usmani, Robert Bona, Gabriela Chiosis   +2 more
openaire   +1 more source

Radiosensitization of human lung cancer cells by the novel purine-scaffold Hsp90 inhibitor, PU-H71

International Journal of Molecular Medicine, 2014
Yoshihiro Fujii, Ryuichi Okayasu, Ken Ohnishi   +2 more
exaly  

Epichaperome-targeted myocardial imaging by 124I-PU-H71 PET

Clinical and Translational Imaging
Josef J Fox, Milan Grkovski, Mark P S Dunphy   +2 more
exaly