Results 41 to 50 of about 6,737 (128)

The LDH‐H3K18La‐Nur77 Axis Potentiates Immune Escape in Small Cell Lung Cancer

Advanced Science, Volume 12, Issue 34, September 11, 2025.
Lactate from SCLC tumors induces H3K18 lactylation in naïve CD8+ T cells, upregulating Nurr77 and enhancing tonic TCR signaling. This leads to T cell hyporesponsiveness to stimulation, impairing antitumor immunity and reducing immunotherapy efficacy.
Xiaoling Shang, Bo Cheng, Chenyue Zhang, Chenglong Zhao, Ruiqing Wang, Xun Zhang, Dizhi Jiang, Xinyu Zhang, Xinyue Ma, Hongyuan Mao, Zerun Li, Chenhan Huang, Tianzi Wang, Kaiyue Guo, Liwen Wang, Ning Tang, Haiyong Wang   +16 more
wiley   +1 more source

Methods and codes for reservoir–atmosphere C-14 age offset calculations [PDF]

, 2015
Author Posting. © The Author(s), 2015. This is the author's version of the work. It is posted here by permission of Elsevier for personal use, not for redistribution.
Soulet, Guillaume
core   +1 more source

Complex population genetic structure of the bark beetle predator Thanasimus formicarius (L.) (Coleoptera: Cleridae) across its European range

Agricultural and Forest Entomology, Volume 27, Issue 3, Page 437-451, August 2025.
Abstract Thanasimus formicarius (L.) (Coleoptera: Cleridae) is an important bark beetle predator and can reduce bark beetle population densities of some of the most severe forest pests in Europe. We analysed the population genetics and phylogeography of T.
Eva Papek, Amina Derlić, Markus Melin, Alain Roques, Dragos Cocos, Martin L. Schroeder, Milan Pernek, Dimitrios N. Avtzis, Paulius Zolubas, David T. Williams, Juan A. Pajares, Oğuzhan Sarikaya, Roman Pavlin, Sevdalin Belilov, Martin M. Gossner, M. Lukas Seehausen, Anna Wierzbicka, Lara Kundtner, Christian Stauffer, Martin Schebeck   +19 more
wiley   +1 more source

Effect of TraN key residues involved in DNA binding on pIP501 transfer rates in Enterococcus faecalis

Frontiers in Molecular Biosciences
Conjugation is a major mechanism that facilitates the exchange of antibiotic resistance genes among bacteria. The broad-host-range Inc18 plasmid pIP501 harbors 15 genes that encode for a type IV secretion system (T4SS).
Claudia Michaelis, Tamara M. I. Berger, Kirill Kuhlmann, Rangina Ghulam, Lukas Petrowitsch, Maria Besora Vecino, Bernd Gesslbauer, Bernd Gesslbauer, Bernd Gesslbauer, Tea Pavkov-Keller, Tea Pavkov-Keller, Tea Pavkov-Keller, Walter Keller, Walter Keller, Walter Keller, Elisabeth Grohmann   +15 more
doaj   +1 more source

Approximate quantum error correction for generalized amplitude damping errors

, 2014
We present analytic estimates of the performances of various approximate quantum error correction schemes for the generalized amplitude damping (GAD) qubit channel. Specifically, we consider both stabilizer and nonadditive quantum codes.
Cafaro, Carlo, van Loock, Peter
core   +1 more source

CTCF and BORIS Regulate Rb2/p130 Gene Transcription: A Novel Mechanism and a New Paradigm for Understanding the Biology of Lung Cancer [PDF]

, 2011
Although innumerable investigations regarding the biology of lung cancer have been carried out, many aspects thereof remain to be addressed, including the role played by the retinoblastoma-related protein Rb2/ p130 during the evolution of this disease.
Bagella, L, Fiorentino, FP, Giordano, A., Macaluso, M, Miranda, F, Montanari, M, RUSSO, Antonio   +6 more
core   +1 more source

PP2A Promotes the Symmetric Division of MUC1‐Dominant Cancer Stem‐Like Cells in Small Cell Lung Cancer

Advanced Science, Volume 12, Issue 25, July 3, 2025.
During the G2/M phase, mucin1 (MUC1) activates protein phosphatase 2A (PP2A), leading to reduced phosphorylation of protein kinase C ζ (PKCζ) and NUMB, which promotes symmetric division and expansion of cancer stem‐like cells (CSLCs), thereby driving tumorigenesis. Combined inhibition of the MUC1–PP2A axis using LB100/GO203 with etoposide restores PKCζ
Shengze Li, Xinran Dong, Kexing Gao, Yiyang Wang, Min Li, Huayun Deng, Shuangyu Ma, Yaping Lv, Wei Jin, Quanfu Li, Yuming Wang, Xiaodong Liao, Kangjing Bian, Aiwu Zhou, Chengping Hu, Lei Huang   +15 more
wiley   +1 more source

A new bound for the 2/3 conjecture [PDF]

, 2012
We show that any n-vertex complete graph with edges colored with three colors contains a set of at most four vertices such that the number of the neighbors of these vertices in one of the colors is at least 2n/3. The previous best value, proved by Erdos,
Baber, CHUN-HUNG LIU, DANIEL KRÁL', Erdős, JEAN-SÉBASTIEN SERENI, PETER WHALEN, ZELEALEM B. YILMA   +6 more
core   +7 more sources

Animal models of lung cancer: Phenotypic comparison of different animal models of lung cancer and their application in the study of mechanisms

Animal Models and Experimental Medicine, Volume 8, Issue 7, Page 1229-1252, July 2025.
Grafts used to construct lung cancer animal models come from various sources, primarily cell lines, patient‐derived tumor tissues, and circulating tumor cells. Based on the sources of grafts and research objectives, lung cancer animal models can be categorized into several types: chemical‐induced models, orthotopic transplantation models, heterotopic ...
Zixuan Yang, Xianbin Zhao, Lili Tan, Pingxinyi Que, Tong Zhao, Wei Huang, Dejiao Yao, Songqi Tang   +7 more
wiley   +1 more source

Midkine Promotes Tumor Growth and Attenuates the Effect of Cisplatin in Small Cell Lung Cancer

Cancer Medicine, Volume 14, Issue 13, July 2025.
ABSTRACT Purpose Small cell lung cancer (SCLC) is a highly aggressive disease associated with poor patient survival rates. The addition of an anti‐programmed death ligand 1 antibody to platinum combination chemotherapy can improve its prognosis. However, only a few patients achieve a long‐term response; thus, establishing new therapies for SCLC is ...
Shotaro Ito, Jun Sakakibara‐Konishi, Mineyoshi Sato, Tetsuaki Shoji, Megumi Furuta, Hirofumi Takahashi, Kosuke Tsuji, Daisuke Morinaga, Masahiro Kashima, Hidenori Kitai, Junko Kikuchi, Eiki Kikuchi, Kanako C. Hatanaka, Yutaka Hatanaka, Kyoko Hida, Takuro Noguchi, Satoshi Konno   +16 more
wiley   +1 more source