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Frontiers in Cellular and Infection Microbiology, 2023 IntroductionInfections caused by drug-resistant Klebsiella pneumoniae are now a serious problem for public health, associated with high morbidity and mortality due to limited treatment options.
Chawalit Chatupheeraphat +2 more
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K11-Linked Polyubiquitination in Cell Cycle Control Revealed by a K11 Linkage-Specific Antibody [PDF]
Molecular Cell, 2010 Polyubiquitination is a posttranslational modification where ubiquitin chains containing isopeptide bonds linking one of seven ubiquitin lysines with the C terminus of an adjoining ubiquitin are covalently attached to proteins. While functions of K48- and K63-linked polyubiquitin are understood, the role(s) of noncanonical K11-linked chains is less ...
Marissa L Matsumoto +2 more
exaly +3 more sources
Identification of Bacteriophage K11 Genomic Promoters for K11 RNA Polymerase [PDF]
BMB Reports, 2002 Only one natural promoter that interacts with bacteriophage K11 RNA polymerase has so far been identified. To identify more, in the present study restriction fragments of the phage genome were individually assayed for transcription activity in vitro. The K11 genome was digested with two 4-bp-recognizing restriction enzymes, and the fragments cloned in ...
Eunsung Junn, Changwon Kang
exaly +3 more sources
K11-linked ubiquitin chains as novel regulators of cell division [PDF]
Trends in Cell Biology, 2011 Modification of proteins with ubiquitin chains is an essential regulatory event in cell cycle control. Differences in the connectivity of ubiquitin chains are believed to result in distinct functional consequences for the modified proteins. Among eight possible homogenous chain types, canonical Lys48-linked ubiquitin chains have long been recognized to
Adam P Williamson, Michael Rape
exaly +3 more sources
Unique Structural, Dynamical, and Functional Properties of K11-Linked Polyubiquitin Chains [PDF]
Structure, 2013 K11-linked polyubiquitin chains play important signaling and regulatory roles in both degradative and nonproteolytic pathways in eukaryotes. To understand the structural basis of how these chains are recognized and distinguished from other polyubiquitins, we determined solution structures of K11-linked diubiquitin (K11-Ub2) in the absence and presence ...
Carlos A Castaneda +2 more
exaly +4 more sources
The Design and Construction of K11: A Novel α-Helical Antimicrobial Peptide [PDF]
International Journal of Microbiology, 2012 Amphipathic α-helical antimicrobial peptides comprise a class of broad-spectrum agents that are used against pathogens. We designed a series of antimicrobial peptides, CP-P (KWKSFIKKLTSKFLHLAKKF) and its derivatives, and determined their minimum ...
Huang Jin-Jiang +4 more
doaj +3 more sources
Cloning and Purification of Bacteriophage K11 RNA Polymerase [PDF]
BioTechniques, 1999 Minqing Rong +2 more
doaj +3 more sources
Journal of Translational Medicine, 2023 Objectives Gastrointestinal stromal tumors (GISTs) carrying different KIT exon 11 (KIT-11) mutations exhibit varying prognoses and responses to Imatinib. Herein, we aimed to determine whether computed tomography (CT) radiomics can accurately stratify KIT-
Qing-Wei Zhang +13 more
doaj +1 more source
Synthesis and Analysis of K11-Linked Ubiquitin Chains [PDF]
Biophysical Journal, 2012 Much has been learned about protein ubiquitination by studying the structural, biochemical, and biophysical properties of ubiquitin chains in vitro. However, these analyses were limited to K48-, K63-linked, and linear ubiquitin chains. Only recently, enzymatic and chemical assembly systems for the remaining chain types have been developed.
Anja, Bremm, David, Komander
openaire +3 more sources
Beamline K11 DIAD: a new instrument for dual imaging and diffraction at Diamond Light Source [PDF]
Journal of Synchrotron Radiation, 2021 The Dual Imaging and Diffraction (DIAD) beamline at Diamond Light Source is a new dual-beam instrument for full-field imaging/tomography and powder diffraction. This instrument provides the user community with the capability to dynamically image 2D and 3D complex structures and perform phase identification and/or strain mapping using micro-diffraction.
Christina Reinhard +23 more
openaire +2 more sources