Results 11 to 20 of about 10,104 (229)

Structural basis of K11/K48-branched ubiquitin chain recognition by the human 26S proteasome [PDF]

Nature Communications
Beyond the canonical K48-linked homotypic polyubiquitination for proteasome-targeted proteolysis, K11/K48-branched ubiquitin (Ub) chains are involved in fast-tracking protein turnover during cell cycle progression and proteotoxic stress.
Piotr Draczkowski, Szu-Ni Chen, Ting Chen, Yong-Sheng Wang, Hsin-An Shih, Jessica Y. C. Huang, Ming-Chieh Tsai, Shu-Yu Lin, Steven Lin, Rosa Viner, Yuan-Chih Chang, Kuen-Phon Wu, Shang-Te Danny Hsu   +12 more
doaj   +3 more sources

The Design and Construction of K11: A Novel α-Helical Antimicrobial Peptide [PDF]

International Journal of Microbiology, 2012
Amphipathic α-helical antimicrobial peptides comprise a class of broad-spectrum agents that are used against pathogens. We designed a series of antimicrobial peptides, CP-P (KWKSFIKKLTSKFLHLAKKF) and its derivatives, and determined their minimum ...
Huang Jin-Jiang, Lu Jin-Chun, Lu Min, Huang Qing-Shan, Li Guo-Dong   +4 more
doaj   +4 more sources

RNF114 and RNF166 exemplify reader-writer E3 ligases that extend K11 polyubiquitin onto sites of MARUbylation [PDF]

EMBO Journal
Ubiquitin (Ub) cooperates with other post-translational modifications to provide a tiered opportunity for protein regulation. Deltex E3 ligases were previously implicated in ubiquitylation of ADP-ribose (ADPr)-containing macromolecules in vitro ...
Rachel E Lacoursiere, Kapil Upadhyaya, Daniel S Bejan   +2 more
exaly   +3 more sources

Synergistic effect and antibiofilm activity of the antimicrobial peptide K11 with conventional antibiotics against multidrug-resistant and extensively drug-resistant Klebsiella pneumoniae

Frontiers in Cellular and Infection Microbiology, 2023
IntroductionInfections caused by drug-resistant Klebsiella pneumoniae are now a serious problem for public health, associated with high morbidity and mortality due to limited treatment options.
Chawalit Chatupheeraphat, Sirirat Luk-In, Luk-In Sirirat   +2 more
exaly   +3 more sources

The CCL-K11 ongoing key comparison. Final report for the year 2015

Metrologia, 2016
Lasers from two national metrological institutes (NMIs) were compared in 2015 as part of the CCL-K11 ongoing key comparison, initiated by the 13th meeting of the Comité Consultative des Longuers (CCL) in 2007. The absolute frequency of R(127) 11-5 transitions of molecular iodine was measured for these lasers following the technical ...
Seppä, Jeremias, Matus, Michael, Robertsson, Lennart, van den Berg, Steven, Czulek, Dariusz   +4 more
core   +6 more sources

Kefir-derived probiotic mixture for children with autism spectrum disorder: a double-blind randomized clinical trial [PDF]

BMC Pediatrics
Purpose Emerging evidence suggests associations between gut microbiota patterns and autism-related behavioral and gastrointestinal features, increasing interest in probiotic interventions.
Sarha A. L. de Queiroz, Deivis O. Guimarães, Lara A. Ferreira, Larissa Martinelli, Rebeca M. M. Werly, Raphaela F. Amorim, Lívia B. S. S. Holzbach, Roberto Badaró, Alex A. B. Santos, Elisardo C. Vasquez, Racire S. Silva   +10 more
doaj   +2 more sources

Identification of Bacteriophage K11 Genomic Promoters for K11 RNA Polymerase [PDF]

BMB Reports, 2002
Only one natural promoter that interacts with bacteriophage K11 RNA polymerase has so far been identified. To identify more, in the present study restriction fragments of the phage genome were individually assayed for transcription activity in vitro. The K11 genome was digested with two 4-bp-recognizing restriction enzymes, and the fragments cloned in ...
Eunsung Junn, Changwon Kang
exaly   +3 more sources

K11-Linked Polyubiquitination in Cell Cycle Control Revealed by a K11 Linkage-Specific Antibody [PDF]

Molecular Cell, 2010
Polyubiquitination is a posttranslational modification where ubiquitin chains containing isopeptide bonds linking one of seven ubiquitin lysines with the C terminus of an adjoining ubiquitin are covalently attached to proteins. While functions of K48- and K63-linked polyubiquitin are understood, the role(s) of noncanonical K11-linked chains is less ...
Christine Yu, Lilian Phu, Donald S Kirkpatrick   +2 more
exaly   +3 more sources

The deubiquitinating enzyme Cezanne stabilizes BRCA1 by counteracting APC/C and Ube2S-dependent Lys11-linked ubiquitination. [PDF]

PLoS Biology
The breast and ovarian tumor suppressor BRCA1 is a cell cycle-regulated protein and tumors with reduced BRCA1 protein level may share molecular features of BRCA1-mutant tumor and respond to PARPi therapy. Here, we identify that BRCA1 protein stability is
Longqiang Wang, Xiao Wu, Atanu Paul, Jun Yao, Bin Wang   +4 more
doaj   +2 more sources

Synthesis and Analysis of K11-Linked Ubiquitin Chains [PDF]

Methods in Molecular Biology, 2012
Much has been learned about protein ubiquitination by studying the structural, biochemical, and biophysical properties of ubiquitin chains in vitro. However, these analyses were limited to K48-, K63-linked, and linear ubiquitin chains. Only recently, enzymatic and chemical assembly systems for the remaining chain types have been developed.
Anja Bremm, David Komander, Komander David   +2 more
exaly   +4 more sources