Results 21 to 30 of about 11,042 (207)

K11-Linked Polyubiquitination in Cell Cycle Control Revealed by a K11 Linkage-Specific Antibody [PDF]

Molecular Cell, 2010
Polyubiquitination is a posttranslational modification where ubiquitin chains containing isopeptide bonds linking one of seven ubiquitin lysines with the C terminus of an adjoining ubiquitin are covalently attached to proteins. While functions of K48- and K63-linked polyubiquitin are understood, the role(s) of noncanonical K11-linked chains is less ...
Vishva Dixit, Donald S Kirkpatrick, Michael Rape   +2 more
exaly   +3 more sources

Synthesis and Analysis of K11-Linked Ubiquitin Chains [PDF]

Methods in Molecular Biology, 2012
Much has been learned about protein ubiquitination by studying the structural, biochemical, and biophysical properties of ubiquitin chains in vitro. However, these analyses were limited to K48-, K63-linked, and linear ubiquitin chains. Only recently, enzymatic and chemical assembly systems for the remaining chain types have been developed.
David Komander, Anja Bremm
exaly   +4 more sources

Unique Structural, Dynamical, and Functional Properties of K11-Linked Polyubiquitin Chains [PDF]

Structure, 2013
K11-linked polyubiquitin chains play important signaling and regulatory roles in both degradative and nonproteolytic pathways in eukaryotes. To understand the structural basis of how these chains are recognized and distinguished from other polyubiquitins, we determined solution structures of K11-linked diubiquitin (K11-Ub2) in the absence and presence ...
Castañeda, Carlos A, Kashyap, Tanuja R, Nakasone, Mark A, Krueger, Susan, Fushman, David   +4 more
openaire   +5 more sources

Penicillin-sensitive DD-carboxypeptidases from Streptomyces strains R39 and K11 [PDF]

Biochemistry, 1972
The two penicillin-sensitive DD-carboxypeptidases from Streptomyces R39 and K11 are anionic at pH 8. They specifically recognize a C-terminal L-R3-D-alanyl-D sequence with a long side chain at the R3 position. The two enzymes differ from each other with respect to: (1) the effects of ionic strength on activity, (2) the influence exerted on activity by ...
Leyh-Bouille, Mélina, Nakel, Marlies, Frère, Jean-Marie, Johnson, Kenneth, Ghuysen, Jean-Marie, Nieto, Manuel, Perkins, Harold R.   +6 more
openaire   +4 more sources

The deubiquitinating enzyme Cezanne stabilizes BRCA1 by counteracting APC/C and Ube2S-dependent Lys11-linked ubiquitination. [PDF]

PLoS Biology
The breast and ovarian tumor suppressor BRCA1 is a cell cycle-regulated protein and tumors with reduced BRCA1 protein level may share molecular features of BRCA1-mutant tumor and respond to PARPi therapy. Here, we identify that BRCA1 protein stability is
Longqiang Wang, Xiao Wu, Atanu Paul, Jun Yao, Bin Wang   +4 more
doaj   +2 more sources

Antimicrobial Peptide K11 Selectively Recognizes Bacterial Biomimetic Membranes and Acts by Twisting Their Bilayers

Pharmaceuticals, 2020
K11 is a synthetic peptide originating from the introduction of a lysine residue in position 11 within the sequence of a rationally designed antibacterial scaffold.
Francisco Ramos-Martín, Claudia Herrera-León, Viviane Antonietti, Pascal Sonnet, Catherine Sarazin, Nicola D’Amelio   +5 more
doaj   +2 more sources

The CCL-K11 ongoing key comparison. Final report for 2023

Metrologia
Main text Six lasers from six national metrological institutes (NMIs) were compared in the year 2023 as part of the CCL-K11 ongoing key comparison, initiated by the 13th meeting of the Comité Consultative des Longueurs (CCL) in 2007. The absolute frequency of theses lasers was measured in three different node laboratories following the ...
M Matus, H S Margolis, J Seppä, H Karlsson, C-H Hanquist, A J Lancaster, A J Lewis, M Brawer, M del Mar Pérez, M Bisi, J Hald, G Zechner   +11 more
core   +4 more sources

Induction of Drought Stress Resistance by Multi-Functional PGPR Bacillus licheniformis K11 in Pepper

The Plant Pathology Journal, 2013
Drought stress is one of the major yield affecting factor for pepper plant. The effects of PGPRs were analyzed in relation with drought resistance. The PGPRs inoculated pepper plants tolerate the drought stress and survived as compared to non-inoculated ...
Jong-Hui Lim, Sang-Dal Kim
doaj   +2 more sources

circZNF148 Drives Glucose Metabolism Reprogramming to Enhance Metastasis and Immune Evasion via HK1 Stabilization in Triple-Negative Breast Cancer. [PDF]

Adv Sci (Weinh)
CircZNF148 stabilizes HK1 through deubiquitinase recruitment, thereby enhancing glycolysis and lactate production. Elevated lactate promotes PD‑L1 lactylation and membrane accumulation while suppressing CD8+ T‐cell cytotoxicity, collectively facilitating immune evasion and malignant progression in TNBC.
Jin Y, Zhao W, Wang L, Wang J, Zhao K, Luo D, Wang Y, Yang Y, Yang J, Li Y, Chen T, Han D, Wang Z, Li X, Chen B, Wang L, Liang Y, Yang Q.   +17 more
europepmc   +2 more sources

USP4-Dependent CHAF1B Stabilization Regulates Distinct SETDB1 Ubiquitin States Linked to AKT T308 Signaling and Lipogenic Remodeling in HCC. [PDF]

Adv Sci (Weinh)
USP4 stabilizes CHAF1B by limiting K48‐linked ubiquitination. Stabilized CHAF1B supports UHRF1‐associated K63‐linked SETDB1 ubiquitination and cytoplasmic redistribution, whereas CHAF1B loss favors VHL‐dependent K11‐associated degradative ubiquitination and proteasomal loss of SETDB1.
Bian S, Tong Y, Ni W, Tang Z, Chen W, Ma K, Jiang L, Shao J, He X, Zheng W.   +9 more
europepmc   +2 more sources