Results 91 to 100 of about 139,282 (292)
Advanced Dental Composite Technology via Bisilanized Dual‐Action Nanofillers for Biofilm Control
Advanced Science, EarlyView.A multimodal research strategy has led to the development of an innovative resin‐based composite (RBC) with dual antibacterial action. The S_CM‐RBC formula showed strong antibiofilm activity, excellent mechanical strength, and biosafety. It effectively controlled oral bacteria in prevention of caries recurrence, and maintained pulp health in a rat ...
Chenmin Yao +11 more
wiley +1 more source
Advanced Science, EarlyView.High glucose triggers corneal endothelial dysfunction by impairing FOXO1‐mediated ITPR1 transcription, leading to disrupted mitochondria‐associated membrane (MAM) integrity and defective ER‐to‐mitochondria Ca2+ transfer. This study develops an innovative viscous DES‐AAV‐Foxo1 delivery system with enhanced transfection efficiency. This non‐invasive gene
Hongran Zhao +10 more
wiley +1 more source
Exploring RNA-targeted gene therapy approaches for hypertrophic cardiomyopathy [PDF]
, 2012 Relatório de projeto no âmbito do Programa de Bolsas Universidade de Lisboa/Fundação Amadeu Dias (2011/2012). Universidade de Lisboa.
Freitas, Ana
core
Exact formula for currents in strongly pumped diffusive systems
, 2009 We analyze a generic model of mesoscopic machines driven by the nonadiabatic variation of external parameters. We derive a formula for the probability current; as a consequence we obtain a no-pumping theorem for cyclic processes satisfying detailed ...
A. Kolomeisky +23 more
core +1 more source
Advanced Science, EarlyView.This study reveals the dual role of celecoxib in intervertebral disc degeneration. While low concentrations are protective, high concentrations induce toxicity by upregulating HSP90, which synergizes with USP15 to deubiquitinate and stabilize RBX1. This leads to degradation of COMMD1/ATP7B, copper dyshomeostasis, and ultimately, cuproptosis.
Youfeng Guo +11 more
wiley +1 more source
NFAT2 in the regulation of CAII and V-ATPase mRNA expression in osteoclast-like cells and intervention study of PEMF [PDF]
, 2016 目的：研究低频脉冲电磁场(PEMF)对去卵巢大鼠核因子κB受体活化因子（RANK）、活化T细胞核因子(NFATc1/NFAT2)、碳酸酐酶II（CAII）、空泡型H+三磷酸腺苷转运酶（V-ATPase）基因表达的影响；研究NFAT2对CAII和V-ATPase基因表达的调控作用。 方法：1.选取48只雌性SD大鼠，分为三组，分别为SHAM（假手术）组、OVX（去卵巢）组、OVX+PEMF组，OVX+PEMF组随机选一半被PEMF干预14天和28天，测雌激素和骨密度。RT-PCR检测NFAT2、RANK ...
傅继凡
core
Advanced Science, EarlyView.This study reveals that Alzheimer's disease–linked APP expression in bone‐forming cells drives skull bone marrow remodeling and alters its vascular connections to the brain. These changes disrupt immune cell trafficking, cerebral blood flow, and cognition. Targeting bone marrow macrophages restores brain function, highlighting a previously unrecognized
Lei Xiong +6 more
wiley +1 more source
Optimizing Dothistroma septosporum infection of Pinus radiata and the development of red-band disease : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Genetics at Massey University, Palmerston North, New Zealand [PDF]
, 2006 The filamentous fungus Dothistroma septosporum infects pine species throughout the world causing red-band disease, one of the most serious diseases of conifer species. In NZ, a clonally derived asexual strain of D. septosporum was identified in 1964, and
Barron, Naydene
core
Animal Models and Experimental Medicine, EarlyView.Over one billion people worldwide suffer from obesity, and the number is continually rising. Animal models, especially mouse models, are crucial to identifying the genetic components of complex disorders and exploring the potential applications of these genetic findings.
Hanifa J. Abu‐Toamih Atamni +7 more
wiley +1 more source