Results 151 to 160 of about 139,282 (292)

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur   +6 more
wiley   +1 more source

CLC3 regulates V-ATPase to enhance lysosomal degradation and cisplatin resistance in cervical cancer cells. [PDF]

open access: yesCell Death Discov
Chen C   +9 more
europepmc   +1 more source

Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction

open access: yesPROTEOMICS, EarlyView.
ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella   +6 more
wiley   +1 more source

Patterns of cytokine gene expression of naïve and memory T lymphocytes in vivo. [PDF]

open access: yes, 2002
Bailey, S.   +3 more
core  

Migrasomes, Matrix‐Bound Nanovesicles, and More: Messengers in the Matrix

open access: yesPROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) and particles (EPs) are diverse micro‐ and nanoparticles that circulate in bodily fluids and can attach to, or be deposited onto, the extracellular matrix (ECM) and other surfaces. To date, the nomenclature and classification of matrix‐bound or matrix‐associated EVs and EPs (MEVPs) have been unclear, largely due to
Anna V. Kolesov   +3 more
wiley   +1 more source

Monitoring of secondary and tertiary structure changes in the gastric H+/K+-ATPase by infrared spectroscopy.

open access: yesEuropean Journal of Biochemistry, 2001
F. Scheirlinckx   +3 more
semanticscholar   +1 more source

Multiple Roles of Protamine Kinase SRPK1 and Phosphatase PP1γ in Sperm Development

open access: yesPROTEOMICS, EarlyView.
ABSTRACT Protein phosphorylation regulates key events of male germ cell differentiation. In the testis, SRPK1 and PP1γ are involved in protamine phosphorylation and dephosphorylation, respectively, and their deregulation is linked to defective chromatin structure and male infertility.
Alberto de la Iglesia   +7 more
wiley   +1 more source

NorQD AAA+ complex drives metal insertion by a twisting mechanism. [PDF]

open access: yesNat Commun
Kahle M   +5 more
europepmc   +1 more source

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