Results 41 to 50 of about 297,432 (219)

Emission-line Stacking of 21 cm Intensity Maps with MeerKLASS: Inference Pipeline and Application to the L-band Deep-field Data

The Astrophysical Journal Supplement Series
We present a novel analysis of observational systematics through the emission-line stacking of the MeerKLASS L -band deep-field intensity maps, following the detection in MeerKLASS Collaboration et al.
Zhaoting Chen, Steven Cunnington, Alkistis Pourtsidou, Laura Wolz, Marta Spinelli, José Luis Bernal, Matilde Barberi-Squarotti, Stefano Camera, Isabella P. Carucci, José Fonseca, Keith Grainge, Melis O. Irfan, Mario G. Santos, Jingying Wang, (MeerKLASS Collaboration)   +14 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

21 cm Signal from the Thermal Evolution of Lyα during Cosmic Dawn

The Astrophysical Journal
The Ly α photons couple the spin temperature of neutral hydrogen (H I ) to the kinetic temperature during the era of cosmic dawn (CD). During this process, they also exchange energy with the medium, heating and cooling the H I .
Janakee Raste, Shiv K. Sethi
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Reconstruction of Cosmological Initial Density Field with Observations from the Epoch of Reionization

The Astrophysical Journal
The initial density distribution provides a basis for understanding the complete evolution of cosmological density fluctuations. While reconstruction in our local Universe exploits the observations of galaxy surveys with large volumes, observations of ...
Meng Zhou, Yi Mao
doaj   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

WALLABY Pilot Survey and ASymba: Comparing H i Detection Asymmetries to the SIMBA Simulation

The Astronomical Journal
An avenue for understanding cosmological galaxy formation is to compare morphometric parameters in observations and simulations of galaxy assembly. In this second paper of the ASymba: Asymmetries of H i in SIMBA Galaxies series, we measure atomic gas (H ...
Mathieu Perron-Cormier, Nathan Deg, Kristine Spekkens, Mark L. A. Richardson, Marcin Glowacki, Kyle A. Oman, Marc A. W. Verheijen, Nadine A. N. Hank, Sarah Blyth, Helga Dénes, Jonghwan Rhee, Ahmed Elagali, Austin Xiaofan Shen, Wasim Raja, Karen Lee-Waddell, Luca Cortese, Barbara Catinella, Tobias Westmeier   +17 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

MeerKAT H i Observations of Low Surface Brightness/Ultradiffuse Galaxy Candidates Projected around Two Southern Loose Groups

The Astrophysical Journal Letters
A large catalog of low surface brightness galaxies (LSBGs) from the Dark Energy Survey showed significant clustering around nearby galaxy groups and clusters.
Chandreyee Sengupta, Tom C. Scott, Hao Chen, Hyein Yoon, Yogesh Chandola, Mengtian Li, Gyula I. G. Józsa, O. Ivy Wong, Yin-Zhe Ma, Patricio Lagos, Ruta Kale, Denis Tramonte   +11 more
doaj   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source