Results 171 to 180 of about 1,149,495 (269)

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

In silico design of a multiantigenic and multiepitope chimeric protein as a vaccine candidate against <i>Renibacterium salmoninarum</i>. [PDF]

Front Cell Infect Microbiol
Araneda J, Flores-Herrera PA, Acevedo W, Marshall SH, Gómez FA.   +4 more
europepmc   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Noninvasive whole-brain imaging of glymphatic dynamics. [PDF]

Sci Adv
Wang N, Yu X, Lowerison M, Li Q, Canning AJ, He P, Dang L, Degan S, Mace B, Xu Y, Yao R, Li J, Zhou T, Luo J, Lin BZ, Turner DA, Liu X, Ta D, Lovell J, Vo-Dinh T, Feng W, Song P, Yang W, Yao J.   +23 more
europepmc   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Suppressed <i>SF3B1</i> Expression Lowers <i>METTL3</i> Transcription and m⁶A RNA Expression. [PDF]

Int J Mol Sci
Choi N, Ashraf H, Shen H.
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

RUNX1 is a mediator of fibrotic activation and epigenetic memory in lung fibroblasts. [PDF]

Am J Respir Cell Mol Biol
Gilbert RM, Jones DL, Wellmerling J, Caporarello N, Meridew JA, Choi KM, Haak AJ, Link PA, Tan Q, Lee JH, Ordog T, Ligresti G, Tschumperlin DJ.   +12 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Comprehensive mapping of human CD4⁺ T cell epitopes for Nipah and measles as prototype Paramyxoviruses. [PDF]

Cell Rep Med
Tarke A, Macias M, Morales CF, Michaelis T, Siddiqui L, Yu ED, Trevizani R, Zuniga A, Zmasek C, Phillips E, Mallal S, Lin B, Estevez JO, Erlich JR, Johnson NV, McLellan JS, Frazier A, da Silva Antunes R, Tan GS, Grifoni A, Sette A.   +20 more
europepmc   +1 more source