Results 171 to 180 of about 20,346,263 (306)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Transcription pause and elongation regulators mediate somatic hypermutation. [PDF]

Nature
Wu L, Yadavalli AD, McAuliffe CC, Ha Q, Barkestani MN, Rommasi F, Fianu I, Senigl F, Schatz DG.   +8 more
europepmc   +1 more source

The Nearest H II Regions.

The Astrophysical Journal, 1952
Stewart Sharpless, Donald Osterbrock
openaire   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Measuring Lyman Continuum Photon Luminosity in H II Regions

This project focuses on measuring the Lyman continuum photon luminosity (Lc) of diffuse H II regions using multi-line observations from the Wisconsin H-Alpha Mapper (WHAM).
Johnshon, Brianna
core   +1 more source

Spatial partitioning of NSD2 defines H3K36me2 as an active mark for repetitive sequence activation. [PDF]

Nat Commun
Jia J, Liu Y, Yu J, Wang J, Zhang Y, Fang Y, Yu Y, Sun Z, Li Z, Tang Y, Shao J, Zhang Y, Song H, Ulianov SV, Huang J, Fang D.   +15 more
europepmc   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Evolution-Informed Viroinformatics Identifies Conserved Immune Targets with Predicted Lower Mutational Vulnerability Across Betacoronaviruses. [PDF]

Viruses
Alshammari J, Alqahtani HA, Alonaizan R, Rahman IU, Alzhrani K, Al-Hoshani N, Alwaili MA, Aziz T.   +7 more
europepmc   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Skyrmion Bubbles by Design in a Centrosymmetric Kagome Magnet. [PDF]

Adv Sci (Weinh)
El Gazzah M, Yasin FS, Jamaluddin S, Bhandari H, Regmi RB, Yu X, Ghimire NJ.   +6 more
europepmc   +1 more source