Results 161 to 170 of about 1,149,495 (269)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

MCM2-7 proteins promote NF-κB transcriptional activity through cooperative promoter recruitment. [PDF]

Biosci Rep
Hong X, Sui M, Li Q, Lu YJ, Nie YH, Li YP, Li WL, Yue XX, Xu J, Billadeau D, Wang T, Deng ZH.   +11 more
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Type I hair cells of striolar and central zones in vestibular organs are essential for head stability and postural control. [PDF]

Proc Natl Acad Sci U S A
Ono K, Lee HJ, Chang HHV, Verdone BM, Wafa T, Ji Y, Huang A, Fitzgerald T, Cullen KE, Wu DK.   +9 more
europepmc   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Evaluation of the influence of enamel thickness on the effectiveness of tooth whitening: an <i>in vitr</i>o study. [PDF]

Med Pharm Rep
Maftouh B, Amessegher FZ, Al Jalil Z, Mazzir N, Jouhadi EM.   +4 more
europepmc   +1 more source

The Formation of H II Regions.

The Astrophysical Journal, 1963
openaire   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

Structural basis of ligand selectivity in FAD/NAD(P)H-dependent dehydrogenases: insights from trypanothione reductase and type II NADH dehydrogenase. [PDF]

Protein Sci
Perrone GCM, Spadone S, Francavilla AL, Morselli S, Todisco S, Ortalli M, Mendoza-Roldan JA, Scaglione V, Sgobba MN, Guerra L, Belluti F, Varani S, Otranto D, De Grassi A, Volpicella M, Pierri CL.   +15 more
europepmc   +1 more source

Formation of H II Regions.

The Astronomical Journal, 1962
openaire   +2 more sources