Results 141 to 150 of about 1,144,964 (311)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Masses, Star Formation Efficiencies, and Dynamical Evolution of 18,000 H ii Regions

The Astrophysical Journal Letters
We present measurements of the masses associated with ∼18,​​​​​000 H ii regions across 19 nearby star-forming galaxies by combining data from JWST, Hubble Space Telescope, MUSE, Atacama Large Millimeter/submillimeter Array, Very Large Array, and MeerKAT ...
Debosmita Pathak, Adam K. Leroy, Ashley. T. Barnes, Todd A. Thompson, Laura A. Lopez, Karin M. Sandstrom, Jiayi Sun, Simon C. O. Glover, Ralf S. Klessen, Eric W. Koch, Kirsten L. Larson, Janice Lee, Sharon Meidt, Patricia Sanchez-Blazquez, Eva Schinnerer, Zein Bazzi, Francesco Belfiore, Médéric Boquien, Ryan Chown, Dario Colombo, Enrico Congiu, Oleg V. Egorov, Cosima Eibensteiner, Sushma Kurapati, Miguel Querejeta, Daniel A. Dale, Timo Kravtsov, Mansi Padave, D. J. Pisano, Erik Rosolowsky, Sumit K. Sarbadhicary, Thomas G. Williams, Remy Indebetouw, Hsi-An Pan, Leonardo Úbeda, Amirnezam Amiri, Frank Bigiel, Guillermo A. Blanc, Kathryn Grasha   +38 more
doaj   +1 more source

Theoretical models for H II regions. II - The extragalactic H II region abundance sequence

The Astrophysical Journal, 1986
M. A. Dopita, I. N. Evans
openaire   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

NGC 6334 and NGC 6357: Hα kinematics and the nature of the H II regions

, 2016
International audienceAims: NGC 6334 and NGC 6357 are amongst the most active, optically visible Galactic star-forming complexes. They are composed of several H ii regions that have a significant impact on their surrounding.
M. R. Samal, Guennou, L., Le Coarer, E., Guennou, L, P. Amram, Amram, P, E. Le Coarer, Adami, C.,, Anderson, LD, Le Coarer, E, Guennou, L.,, Longmore, SN, N. Schneider, Le Coarer, E.,, Purcell, C, Anderson, L. D.,, Adami, C, Longmore, S. N.,, Purcell, C.,, C. Adami, Tigé, J., Purcell, C., Adami, C., Schneider, N, Tigé, J.,, L. D. Anderson, Anderson, L. D., Zavagno, Annie, C. Purcell, Walsh, A, Amram, P., J. Tigé, D. Russeil, Samal, M. R., Amram, P.,, Longmore, S. N., Tige, J, Samal, MR, Walsh, A.,, Walsh, A., A. Zavagno, A. Walsh, Samal, M. R.,, S. N. Longmore, Zavagno, A, Zavagno, A., Schneider, N., Russeil, D, Russeil, D., L. Guennou, Russeil, D.,   +50 more
core   +1 more source

Inferring Interstellar Medium Density, Temperature, and Metallicity from Turbulent H II Regions

The Open Journal of Astrophysics
Reliable nebular emission line diagnostics are essential for accurately inferring the physical properties (e.g. electron temperature, density, pressure, and metallicity) of H~{\small II} regions from spectra.
Larrance Xing, Nicholas Choustikov, Harley Katz, Alex J. Cameron   +3 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Line Emission from Radiation-pressurized H II Regions. II. Dynamics and Population Synthesis

, 2013
Optical and infrared emission lines from H II regions are an important diagnostic used to study galaxies, but interpretation of these lines requires significant modeling of both the internal structure and dynamical evolution of the emitting regions ...
Matzner, C., Tielens, A.G.G.M., Krumholz, M., Verdolini, S., Yeh, S.   +4 more
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Photoevaporated flows from H II regions

, 1996
Artículo de publicación ISIWe model the dynamics of a fast, isothermal ionized stellar wind loaded with mass injected from photoevaporated globules surrounding the massive star.
Cantó, Jorge, Hollenbach, David, Lizano, Susana, Garay Brignardello, Guido   +3 more
core   +1 more source