Results 121 to 130 of about 1,144,964 (311)
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Investigating H II Regions in the Disk of NGC 7331 with the Circumgalactic Hα Spectrograph
The Astrophysical JournalWe investigate the ionized gas kinematics of H ii regions in the disk of NGC 7331 using integral field unit data collected with the Circumgalactic H α Spectrograph (CH α S).
Nazende ipek Kerkeser +5 more
doaj +1 more source
Fluorescence of [Fe II] in H II regions
, 1999 A study of [Fe II] lines at various positions within the H II regions M42 and M43 is presented. The relative intensities of selected optical [Fe II] lines are shown to be correlated with the intensity of the apparent nebular continuous spectrum. Since the continuum of H II regions is known to be mostly stellar radiation scattered by dust intermixed ...
openaire +2 more sources
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Spectroscopy of Supernova Remnants and Candidates in M31
The Astrophysical JournalWith a star formation rate of order 0.4 M _⊙ yr ^−1 , M31 should have a significant population of supernova remnants (SNRs) and, in fact, 156 SNRs and SNR candidates have been suggested by J. H. Lee & M. G.
Nelson Caldwell +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
The Astrophysical JournalBuilding on our previous research involving multiwavelength data from UV to IR, we employ spectroscopic observations of ionized gas, as well as neutral hydrogen gas obtained from the Five-hundred Meter Aperture Spherical Telescope (FAST), to explore the ...
Peng Wei +10 more
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
NGC 628 in SIGNALS: Explaining the Abundance-ionization Correlation in H ii Regions
The Astrophysical JournalThe variations of oxygen abundance and ionization parameter in H ii regions are usually thought to be the dominant factors that produced variations seen in observed emission-line spectra. However, if and how these two quantities are physically related is
Ray Garner III +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source