Results 131 to 140 of about 1,144,964 (311)

ON THE EVOLUTION OF ULTRACOMPACT H ii REGIONS [PDF]

, 2020
The classic model for the pressure-driven expansion of H ii regions is reevaluated to include the gravitational force of the star responsible for the H ii region.
Eric Keto
core  

Galactic Large-scale Filaments Resident in Asymmetric Environments: Clues from Cross-filament Profiles of Density and Temperature

The Astrophysical Journal
Large-scale filaments ubiquitously exist in the Galactic interstellar medium, and their radial profiles offer insights into their formation mechanisms. We present a statistical analysis of molecular hydrogen column density (N(H _2 )) and dust temperature
Keyun Su, Ke Wang, Fengwei Xu, N. K. Bhadari   +3 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Dynamic massive star formation: Radio flux variability in UC H ii regions [PDF]

Context: Theoretical models of early accretion during the formation process of massive stars have predicted that H II regions exhibit radio variability on timescales of decades.
D. Li, Cotton, W.D., Y. Gong, Thompson, M.A., J. S. Urquhart, K. M. Menten, Menten, K.M., A. L. Patel, Tsai, Chao-Wei, Urquhart, J.S., Brunthaler, A., W. D. Cotton, Patel, A.L., A. Y. Yang, Linkert, D., Gong, Y., Chao-Wei Tsai, Li, D., A. Brunthaler, Yang, A.Y., M. A. Thompson, Tsai, C.-W., Yang, A. Y.   +22 more
core   +1 more source

Joint Optical and Infrared Observations of Nitrogen and Oxygen Reveal the Dust-obscured Gas in Haro 3

The Astrophysical Journal
Accurate chemical compositions of star-forming regions provide a critical diagnostic tool for characterizing the star formation history and gas flows that regulate galaxy formation.
Yuguang Chen, Tucker Jones, Ryan L. Sanders, Dario Fadda, Jessica Sutter, Robert Minchin, Nikolaus Z. Prusinski, Sunny Rhoades, Keerthi Vasan GC, Charles C. Steidel, Erin Huntzinger, Paige Kelly, Danielle A. Berg, Fabio Bresolin, Rodrigo Herrera-Camus, Ryan J. Rickards Vaught, Guido Roberts-Borsani, Peter Senchyna, Justin S. Spilker, Daniel P. Stark, Benjamin Weiner, D. Christopher Martin, Mateusz Matuszewski, Rosalie C. McGurk, James D. Neill   +24 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Integral field spectroscopy of H II regions in M33 [PDF]

, 2019
Integral field spectroscopy is presented for star-forming regions in M33. A central area of 300 × 500 pc2 and the external H . II region IC 132, at a galactocentric distance ~19 arcmin (4.69 kpc), were observed with the Potsdam Multi-Aperture ...
Rosa González, Daniel, López-Hernández, Jesus, García Benito, Rubén, Hägele, Guillermo Federico, Vílchez, José, Terlevich, Elena, Terlevich, Roberto, Díaz, Ángeles   +7 more
core  

Oxygen Abundance Throughout the Dwarf Starburst Galaxy IC 10

The Astronomical Journal
Measurements of oxygen abundance throughout galaxies provide insight to the formation histories and ongoing processes. Here we present a study of the gas-phase oxygen abundance in the H ii regions and diffuse gas of the nearby starburst dwarf galaxy, IC ...
Maren Cosens, Shelley A. Wright, Karin Sandstrom, Lee Armus, Norman Murray, Jordan N. Runco, Sanchit Sabhlok, James Wiley   +7 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source