Results 131 to 140 of about 3,875,215 (299)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Unveiling Physical Conditions and Star Formation Processes in the G47 Filamentary Cloud

The Astrophysical Journal
We present a multiwavelength study of the filamentary cloud G47 ( d ∼ 4.44 kpc), which hosts the mid-infrared bubbles N98, B1, and B2. The SMGPS 1.3 GHz continuum map detects ionized emission toward all the bubbles, marking the first detection of ionized
O. R. Jadhav, L. K. Dewangan, A. Haj Ismail, N. K. Bhadari, A. K. Maity, Ram Kesh Yadav, Moustafa Salouci, Patricio Sanhueza, Saurabh Sharma   +8 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Quantification of the Age Dependence of Mid-infrared Star Formation Rate Indicators

The Astrophysical Journal
We combine James Webb Space Telescope images of the nearby galaxy NGC 5194 in the hydrogen recombination line Pa α (1.8756 μ m) from the Cycle 1 program JWST-FEAST with 21 μ m dust continuum images from the Cycle 2 Treasury program JWGT to quantify the ...
Daniela Calzetti, Robert C. Kennicutt, Angela Adamo, Karin Sandstrom, Daniel A. Dale, Bruce Elmegreen, John S. Gallagher, Benjamin Gregg, Varun Bajaj, Torsten Böker, Giacomo Bortolini, Martha Boyer, Matteo Correnti, Ilse De Looze, Bruce T. Draine, Ana Duarte-Cabral, Helena Faustino Vieira, Kathryn Grasha, L. K. Hunt, Kelsey E. Johnson, Ralf S. Klessen, Mark R. Krumholz, Thomas S.-Y. Lai, Drew Lapeer, Sean T. Linden, Matteo Messa, Göran Östlin, Alex Pedrini, Mònica Relaño, Elena Sabbi, Eva Schinnerer, Evan Skillman, Linda J. Smith, Monica Tosi, Fabian Walter, Tony D. Weinbeck   +35 more
doaj   +1 more source

Theoretical models for H II regions. II - The extragalactic H II region abundance sequence

The Astrophysical Journal, 1986
M. A. Dopita, I. N. Evans
openaire   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Masses, Star Formation Efficiencies, and Dynamical Evolution of 18,000 H ii Regions

The Astrophysical Journal Letters
We present measurements of the masses associated with ∼18,​​​​​000 H ii regions across 19 nearby star-forming galaxies by combining data from JWST, Hubble Space Telescope, MUSE, Atacama Large Millimeter/submillimeter Array, Very Large Array, and MeerKAT ...
Debosmita Pathak, Adam K. Leroy, Ashley. T. Barnes, Todd A. Thompson, Laura A. Lopez, Karin M. Sandstrom, Jiayi Sun, Simon C. O. Glover, Ralf S. Klessen, Eric W. Koch, Kirsten L. Larson, Janice Lee, Sharon Meidt, Patricia Sanchez-Blazquez, Eva Schinnerer, Zein Bazzi, Francesco Belfiore, Médéric Boquien, Ryan Chown, Dario Colombo, Enrico Congiu, Oleg V. Egorov, Cosima Eibensteiner, Sushma Kurapati, Miguel Querejeta, Daniel A. Dale, Timo Kravtsov, Mansi Padave, D. J. Pisano, Erik Rosolowsky, Sumit K. Sarbadhicary, Thomas G. Williams, Remy Indebetouw, Hsi-An Pan, Leonardo Úbeda, Amirnezam Amiri, Frank Bigiel, Guillermo A. Blanc, Kathryn Grasha   +38 more
doaj   +1 more source

Neutral hydrogen and star formation in irregular galaxies [PDF]

The Very Large Array and WSTR H I synthesis observations of seven irregular galaxies are presented. The total H I images of four Local Group dwarf irregular galaxies and three larger more distant irregular galaxies are constructed at the identical ...
Skillman, Evan D.
core   +1 more source