Results 151 to 160 of about 1,149,495 (269)

c-Met-targeted NIR-II imaging for precision management of oral squamous cell carcinoma and premalignant lesions. [PDF]

Theranostics
Xia Z, Ji A, Ma Q, Li Y, Lou H, Qian K, Tian J, Yuan Y, Cheng Z, Tao X.   +9 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Identification of targetable epitope surfaces from the high resolution structure of the superantigen Staphylococcal enterotoxin L. [PDF]

Sci Rep
Klamm E, Curato C, Siewert K, Marino SF.
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Linked genetic loci and genotype-dependent temperature effects shape craniofacial morphology in medaka. [PDF]

G3 (Bethesda)
Shinya M, Kimura T, Ikeda T, Nakamura R, Takeda H, Naruse K.   +5 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

An <i>hcp3-vgrG3</i> intergenic region participates in EHEC T6SS expression in addition to the bidirectional promoter and H-NS. [PDF]

Microbiol Spectr
Vazquez-Lopez J, Zambrano-Arguello L, Jimenez-Antaño JM, Constantino-Jonapa LA, Huerta-Cantillo J, Navarro-Garcia F.   +5 more
europepmc   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Emergence of Non-Hemadsorbing African Swine Fever Virus Genotype II Variants and the Evolution of a Vaccine-Derived Strain in Vietnam. [PDF]

Viruses
Tran TCG, Than TT, Lai TNH, Le HD, Nguyen TT, Vu ND, Ngo NBA, Nguyen HT, Nguyen PA, Goonewardene K, Ambagala A, Le VP.   +11 more
europepmc   +1 more source

A Catalogue of H II Regions.

The Astrophysical Journal Supplement Series, 1959
openaire   +1 more source