Results 151 to 160 of about 1,144,964 (311)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Unveiling Physical Conditions and Star Formation Processes in the G47 Filamentary Cloud
The Astrophysical JournalWe present a multiwavelength study of the filamentary cloud G47 ( d ∼ 4.44 kpc), which hosts the mid-infrared bubbles N98, B1, and B2. The SMGPS 1.3 GHz continuum map detects ionized emission toward all the bubbles, marking the first detection of ionized
O. R. Jadhav +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Quantification of the Age Dependence of Mid-infrared Star Formation Rate Indicators
The Astrophysical JournalWe combine James Webb Space Telescope images of the nearby galaxy NGC 5194 in the hydrogen recombination line Pa α (1.8756 μ m) from the Cycle 1 program JWST-FEAST with 21 μ m dust continuum images from the Cycle 2 Treasury program JWGT to quantify the ...
Daniela Calzetti +35 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
The Astrophysical JournalThe molecule 2-aminopropionitrile (2-APN; H _3 CCH(NH _2 )CN) is a chiral precursor of the amino acid alanine and could play an important role in the emergence of the homochirality of life.
Helgi Rafn Hrodmarsson +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Massive Star Formation Triggered by Galactic H II Regions
, 2007 International audienceWe discuss a few aspects of star formation triggered by H II regions. We show that, in a given region, different processes can be at work to trigger star formation in the layer of neutral material collected around the ionized gas ...
Zavagno, Annie, Deharveng, L.
core
Fundamental Parameters for Central Stars of 103 Infrared Bow Shock Nebulae
The Astrophysical JournalStellar bow shock nebulae are arcuate shock fronts formed by the interaction of radiation-driven stellar winds and the relative motion of the ambient interstellar material.
Nikhil Patten +18 more
doaj +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source