Results 231 to 240 of about 1,861,445 (361)

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Following the long-term evolution of sp³-type defects in tritiated graphene using Raman spectroscopy. [PDF]

Nanoscale Adv
Zeller G, Schlösser M, Telle HH.
europepmc   +1 more source

Abundance determination of multiple star-forming regions in the H ii galaxy SDSS J165712.75+321141.4 [PDF]

, 2011
G. F. Hägele, R. García-Benito, E. Pérez‐Montero, Á. I. Díaz, M. V. Cardaci, V. Firpo, E. Terlevich, R. Terlevich   +7 more
openalex   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Progressive Rotator Cuff Tears Alter Strain Across Footprint and Tear Borders: Subregion-Specific Loading Reveals Size-Dependent Mechanical Risk Zones. [PDF]

J Orthop Res
Hoshikawa K, Prado M, Mura N, Jacobs PM, Giambini H.   +4 more
europepmc   +1 more source

Studies of ultracompact H II regions — I. Methanol maser survey of IRAS-selected sources

, 1997
A. Walsh, A. R. Hyland, G. Robinson, M. Burton   +3 more
semanticscholar   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Paused RNA polymerase primes promoters via RNA-mediated stabilisation of transcription factor ERα. [PDF]

Nat Commun
Mann R, Soota D, Das A, Podh NK, Mehta G, Notani D.   +5 more
europepmc   +1 more source

Chemical Abundances of HiiRegions in the Starburst Galaxy NGC 1705 [PDF]

, 2004
Henry Lee, Evan D. Skillman
openalex   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source