Results 151 to 160 of about 2,507,577 (360)
Computational PsychiatryProcesses formalized in classic Reinforcement Learning (RL) theory, such as model-based (MB) control, habit formation, and exploration have proven fertile in cognitive and computational neuroscience, as well as computational psychiatry. Dysregulations in
Angela Mariele Brands +2 more
doaj +1 more source
ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology
Advanced Science, EarlyView.This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li +25 more
wiley +1 more source
mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling
Advanced Science, EarlyView.Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim +4 more
wiley +1 more source
JAMA: The Journal of the American Medical Association, 1892 ABSTRACT In discussing the above subject I start out with these propositions: 1, That any ailment which can be cured by moral suasion, religious enthusiasm or simple will power can not be organic in origin. 2, That the drink babit is curable by the above methods. 3, The drink habit is not primarily a disease of any organ.
openaire +2 more sources
Epidemiological Factors of Periodontal Disease Among South Indian Adults
Journal of Multidisciplinary Healthcare, 2022 Siddharthan Selvaraj,1,2 Nyi Nyi Naing,1 Nadiah Wan-Arfah,3 Sinouvassane Djearamane,4 Ling Shing Wong,5 Vetriselvan Subramaniyan,6 Neeraj Kumar Fuloria,7 Mahendran Sekar,8 Shivkanya Fuloria,7 Mauro Henrique Nogueira Guimarães de Abreu9 1Faculty of ...
Selvaraj S +9 more
doaj
Advanced Science, EarlyView.TaMYB7‐A1 directly activates TaABI5 to enhance ABA signaling and regulate ABA‐GA homeostasis, enforcing seed dormancy. Its superior allele, derived from wild einkorn introgression, harbors a MITE insertion that elevates expression and two amino acid substitutions that enhance transcriptional activity, collectively generating graded PHS resistance for ...
Hao Wang +18 more
wiley +1 more source
Meat Demand under Rational Habit Persistence [PDF]
The objective of this paper is to explore the theoretical implications of a meat demand model with rational habits. To introduce consumption dynamics, habit persistence is used to motivate intertemporally related preferences.
Wohlgenant, Michael K., Zhen, Chen
core +1 more source
Addressing the Quality and Safety Gap Part I: Case Studies in Transforming Hospital Nursing and Building Cultures of Safety [PDF]
, 2009 Presents case studies of strategies four healthcare systems and a state government are using to address underlying causes in flawed systems: strengthening care processes, optimizing staffing, and promoting safe work habits.
core
Improving location prediction services for new users with probabilistic latent semantic analysis
, 2012 Location prediction systems that attempt to determine the mobility patterns of individuals in their daily lives have become increasingly common in recent years.
Jennings, Nicholas R. +2 more
core +2 more sources
Temporal Interference Stimulation Enhances Neural Regeneration
Advanced Science, EarlyView.Temporal interference (TI) stimulation is proposed as a non‐invasive approach to enhance neural regeneration in the deep brain. Theta‐band TI modulation selectively promotes neural progenitor cell differentiation in vitro and augments hippocampal neurogenesis in amouse model of Alzheimer's disease‐like amyloidosis.
Sofia Peressott +15 more
wiley +1 more source