Results 81 to 90 of about 1,237,626 (349)

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

5-HT6R Viral Vector-Mediated Indirect Pathway Activation in the Dorsolateral Striatum: A Discussion on Basal Ganglia Habitual and Goal-Directed Circuits [PDF]

, 2018
Altering maladaptive behavioral tendencies is relevant for clinical interventions, making research on underlying mechanisms of habit essential. Mechanisms of habit are explored here with differential activation of the indirect pathway in the basal ...
Winn, Caleb S
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

"The rate of Chlamydia Trachomatis, Mycoplasma Hominis and Ureaplasma Urealyticum in females with habitual abortion and its comparison with control group " [PDF]

Acta Medica Iranica, 2002
Females abortion is one of the most important sequela of genital infection with chlamydia trachomatis, Mycoplasma hominis and Ureaplasma urealyticum.In this study frequency of Chlamydia trachomatis, Mycoplasma hominis and Ureaplasma urealyticum was ...
Salari MH, Badami N
doaj   +1 more source

Hubungan Habitual Snoring dengan Prestasi Akademis Anak Sekolah Dasar

Sari Pediatri, 2016
Latar belakang. Habitual snoring dapat menimbulkan berbagai komplikasi. Berbagai penelitian menunjukkan terdapat hubungan antara habitual snoring dengan prestasi akademis anak yang rendah, tetapi belum terdapat penelitian mengenai hal ini di Indonesia ...
Hendri Tanu Jaya, Darmawan B. Setyanto, Hanifah Oswari   +2 more
doaj   +1 more source

Level of habitual physical activity and parameters of the cardio-respiratory system in students

Спортивная медицина: наука и практика, 2020
Objective: to analyze the parameters of the cardio-respiratory system in healthy students with different levels of habitual physical activity. Materials and methods: 106 students of Tula State University (61W, 45M, mean age - 22.9±0.4 years (M±m), mean ...
N. Tsarev, Y. Venevtseva
doaj   +1 more source

Performing Surfaces: Designing Research-creation for Agentive Embodiment [PDF]

, 2014
In this discussion I first outline material intersections of bodies and everyday objects that script habitual choreographies as affective extensions of the body.
De Brabandere, Nicole
core   +3 more sources

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Caffeine promotes global spatial processing in habitual and non-habitual caffeine consumers

Frontiers in Human Neuroscience, 2013
Information processing is generally biased toward global cues, often at the expense of local information. Equivocal extant data suggests that arousal states may accentuate either a local or global processing bias, at least partially dependent on the ...
Grace E. Giles, Caroline R. Mahoney, Tad T. Brunye, Holly A. Taylor, Robin B. Kanarek   +4 more
doaj   +1 more source

Health-related quality of life, adiposity, and sedentary behavior in patients with early schizophrenia: Preliminary study [PDF]

, 2012
Objective: To examine adiposity and sedentary behavior in relation to health-related quality of life (QoL) in patients with early schizophrenia. Methods: A cross-sectional study was used to assess adiposity by dual-energy X-ray absorptiometry scans ...
Brar, JS, Ganguli, R, Strassnig, M
core   +1 more source