Results 111 to 120 of about 22,415 (245)

RUNX1/SLAMF3 Axis Drives Immunosuppression to Contribute to Colorectal Cancer Liver Metastasis by Blocking Phagocytosis and Depleting C1QC+ Tumor‐Associated Macrophages

Advanced Science, EarlyView.
This study identifies the RUNX1/SLAMF3 axis as a key driver of colorectal cancer liver metastasis (CRLM). SLAMF3 suppresses macrophage phagocytosis and depletes C1QC⁺ tumor‐associated macrophages, promoting an immunosuppressive microenvironment. Targeting this axis restores macrophage and CD8⁺ T cell activity and reduces metastasis.
Yinheng Luo, Xiaoli Jin, Lan Huang, Dejia Zeng, Nan Zhang, Shiyu Tang, Shu Luo, Samina Ejaz Syed, Ruiwu Dai, Qiu Li, Shufang Liang   +10 more
wiley   +1 more source

The impact of delayed adjuvant chemotherapy on survival in gastric cancer patients with and without preoperative chemotherapy

Annals of Gastroenterological Surgery, EarlyView.
Delayed initiation of adjuvant chemotherapy (AC) is associated with significantly poorer postoperative survival in patients with gastric cancer, irrespective of whether preoperative chemotherapy was administered. These findings emphasize the importance of timely AC initiation to improve long‐term outcomes in this patient population.
Masataka Shimonosono, Takaaki Arigami, Daisuke Matsushita, Yusuke Tsuruda, Ken Sasaki, Kenji Baba, Takao Ohtsuka   +6 more
wiley   +1 more source

ETV2/ER71 regulates hematopoietic regeneration by promoting hematopoietic stem cell proliferation [PDF]

, 2017
Busch, Can-Xin Xu, Daofeng Li, De Val, Ding, Essers, Fang Liu, Ferdous, Gauron, Geissler, Grinenko, Hameed, Huang, Itkin, Ito, Karen Krchma, Karigane, Kataoka, Kimura, Kyunghee Choi, Lee, Lee, Liu, Liu, Love, Ludin, Matsui, McLean, Morimoto, Nagisa Sakurai, Neuhaus, Park, Pirotte, Rasmussen, Salanga, Sato, Shin, Sumanas, Sumanas, Sumanas, Sun, Säwén, Tae-Jin Lee, Thorén, Ting Wang, Walter, Wareing   +46 more
core   +2 more sources

Sound‐Based Assembly of Magnetically Actuated Soft Robots Toward Enhanced Release of Extracellular Vesicles

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
Magnetic soft robots offer promise in biomedicine due to their wireless actuation and rapid response, but current fabrication methods are complex and have limited cellular compatibility. A new, contactless bioassembly strategy using hydrodynamic instabilities is introduced, enabling customizable, centimeter‐scale robots.
Wei Gao, Riccardo Tognato, Micaela Natta, Elena Della Bella, Alessandro Cianciosi, Tiziano Serra   +5 more
wiley   +1 more source

iPRISM: Intelligent Predicting Response to Cancer Immunotherapy through Systematic Modeling

Advanced Intelligent Systems, EarlyView.
The Intelligent Predicting Response to cancer Immunotherapy through Systematic Modeling (iPRISM) model uses data from genes and immune responses to predict how well cancer patients will respond to immunotherapy. Tested on multiple cancer types, iPRISM shows higher accuracy compared to existing methods.
Yinchun Su, Siyuan Li, Qian Wang, Bingyue Pan, Jiyin Lai, Guangyou Wang, Junwei Han, Qingfei Kong   +7 more
wiley   +1 more source

A Phase II Trial of Geriatric Assessment‐Guided Selection of Treatment Intensity in Older Adults With AML

American Journal of Hematology, EarlyView.
ABSTRACT How to select the appropriate intensity of chemotherapy in older adults with acute myeloid leukemia (AML) remains an unanswered question. In a phase II trial of older adults ≥ 60 years with AML (n = 73), we used geriatric assessment (measures of comorbidity burden, physical and cognitive function) to determine fitness for intensive ...
Vijaya R. Bhatt, Christopher S. Wichman, Thuy T. Koll, Alfred L. Fisher, Tanya M. Wildes, Michael Haddadin, Ann M. Berger, James O. Armitage, Sarah A. Holstein, Lori J. Maness, Krishna Gundabolu   +10 more
wiley   +1 more source

Clonal dynamics and somatic evolution of haematopoiesis in mouse. [PDF]

Nature
Kapadia CD, Williams N, Dawson KJ, Watson C, Yousefzadeh MJ, Le D, Nyamondo K, Kodavali S, Cagan A, Waldvogel S, Zhang X, De La Fuente J, Leongamornlert D, Mitchell E, Florez MA, Sosnowski K, Aguilar R, Martell A, Guzman A, Harrison D, Niedernhofer LJ, King KY, Campbell PJ, Blundell J, Goodell MA, Nangalia J.   +25 more
europepmc   +2 more sources

Classical and Late‐Onset SOS/VOD After Allogeneic HSCT: A Japanese Transplant Registry Analysis

American Journal of Hematology, EarlyView.
ABSTRACT Sinusoidal obstruction syndrome/veno‐occlusive disease (SOS/VOD) is a lethal complication of allogeneic hematopoietic stem cell transplantation (allo‐HSCT). According to the 2016 European Society for Blood and Marrow Transplantation criteria, SOS/VOD is classified into classical SOS/VOD and late‐onset SOS/VOD, but their similarities and ...
Kyoko Masuda, Keisuke Kataoka, Masatoshi Sakurai, Yuho Najima, Naonori Harada, Shoko Ukita, Naoyuki Uchida, Noriko Doki, Takahiro Fukuda, Masatsugu Tanaka, Hiroyuki Ohigashi, Jun Ishikawa, Satoshi Yoshihara, Masashi Sawa, Shuichi Ota, Yoshinobu Kanda, Tetsuya Nishida, Makoto Onizuka, Yoshiko Atsuta, Hideki Nakasone, Kimikazu Yakushijin   +20 more
wiley   +1 more source

Transposable elements as genome regulators in normal and malignant haematopoiesis. [PDF]

Blood Cancer J
Prokopov D, Tunbak H, Leddy E, Drylie B, Camera F, Deniz Ö.   +5 more
europepmc   +1 more source

Mixed Autoimmune Hemolytic Anemia: A Systematic Review of Epidemiology, Clinical Characteristics, Therapies, and Outcomes

American Journal of Hematology, EarlyView.
Mixed autoimmune hemolytic anemia (AIHA) is a rare condition characterized by the presence of both warm and cold autoantibodies, often leading to severe, treatment‐resistant hemolysis. In this systematic review of 81 patients across 35 studies, the median age was 45 years with a notable female predominance.
Jeremy W. Jacobs, Sheharyar Raza, Landon M. Clark, Laura D. Stephens, Elizabeth S. Allen, Jennifer S. Woo, Rachel Lane Walden, Cristina A. Figueroa Villalba, Christopher A. Tormey, Caroline G. Stanek, Brian D. Adkins, Evan M. Bloch, Garrett S. Booth   +12 more
wiley   +1 more source