Results 131 to 140 of about 10,512 (289)

Single‐Cell Dissection Reveals Immune Dysregulation After CD5 or CD7‐Directed Chimeric Antigen Receptor T‐Cell Therapy

Advanced Science, EarlyView.
Single‐cell RNA/TCR/BCR sequencing reveals that 5CAR therapy in T‐ALL induces T‐cell exhaustion, reduces EBV‐associated TCRs, lowers TCR/BCR diversity, and increases NK/DC/monocyte activation and function. In contrast, 7CAR therapy reduces multiple pathogen‐associated TCRs, enhances NK cell activation and function, decreases monocyte activation, and ...
Yuechen Luo, Haixiao Zhang, Kaiting Tang, Yiming Wang, Huajiang Dong, Wei Qi, Lingling Shan, Yue Tan, Liping Zhao, Jun Shi, Erlie Jiang, Jing Pan, Xiaoming Feng   +12 more
wiley   +1 more source

DEL‐1 is an Endogenous Senolytic Protein that Inhibits Senescence‐Associated Bone Loss

Advanced Science, EarlyView.
Senescent bone marrow stromal cells accumulate in the aging bone microenvironment, promoting bone degeneration. DEL‐1, an endogenous secreted protein, acts as a natural senolytic that selectively eliminates these cells. By engaging a β3 integrin/CD73/adenosine/p38 MAPK/BCL‐2 pathway, DEL‐1 counters aging‐related bone loss, revealing promising ...
Jong‐Hyung Lim, Kridtapat Sirisereephap, Hui Wang, Giulia Trimaglio, Kyoung‐Jin Chung, Jonathan Korostoff, Tetsuhiro Kajikawa, Xiaofei Li, Meircurius D.C. Surboyo, Tomoki Maekawa, Triantafyllos Chavakis, George Hajishengallis   +11 more
wiley   +1 more source

The Tumor‐to‐Endothelial Transfer of FTO Promotes Vascular Remodeling and Metastasis in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
Integrated omics analysis of matched primary and liver metastatic NPC tumors reveals a unique NOTCH1+ CSC subpopulation exhibiting enhanced stemness properties and tumorigenic capacity. With in vitro and in vivo assays, exosomal transfer of tumor‐derived FTO from NOTCH1+ cells to the endothelium promotes vascular permeability and metastatic potential ...
Chun Wu, Xuefei Liu, Liwen Gu, Jingru Lian, Yuting Wang, Yixin Cheng, Lianhui Duan, Guanyin Huang, Siqi Chen, Boxi Zhao, Sailan Liu, Yufan Yang, Shuqian Zheng, Zijian Lu, Wanping Guo, Jianyang Hu, Wenjing Wang, Zhixiang Zuo, Haiqiang Mai, LinQuan Tang, Songfa Zhang, Feiqiu Wen, Xin Hong, Ling Guo   +23 more
wiley   +1 more source

Wedelolactone, a Novel TLR2 Agonist, Promotes Neutrophil Differentiation and Ameliorates Neutropenia: A Multi‐Omics Approach to Unravel the Mechanism

Advanced Science, EarlyView.
Wedelolactone (WED), a natural TLR2 agonist, promotes neutrophil differentiation and enhances bactericidal function, offering a potential therapeutic strategy for neutropenia. Using a multi‐omics approach, this study reveals that WED activates the TLR2/MEK/ERK pathway, upregulating key transcription factors (PU.1, CEBPβ) to drive neutrophil development.
Long Wang, Zhichao Li, Tianci Hu, Qinyao Li, Linwei Zhang, Xinyue Mei, Xiao Qi, Sheng Liu, Weijie Kong, Jiesi Luo, Anguo Wu, Feihong Huang, Sirui Li, Shuang Dai, Chunxiang Zhang, Rong Li, Jianming Wu   +16 more
wiley   +1 more source

Impaired Iron Homeostasis and Haematopoiesis Impacts Inflammation in the Ageing Process in Down Syndrome Dementia [PDF]

, 2021
Ruma Raha‐Chowdhury, Animesh Alexander Raha, James W. Henderson, Seyedeh Deniz Ghaffari, Monika Grigorova, Jessica Beresford‐Webb, Kieren Allinson, Subhojit Chakraborty, Anthony Holland, Shahid Zaman   +9 more
openalex   +1 more source

Comprehensive Profiling of N6‐methyladnosine (m6A) Readouts Reveals Novel m6A Readers That Regulate Human Embryonic Stem Cell Differentiation

Advanced Science, EarlyView.
This research deciphers the m6A transcriptome by profiling its sites and functional readout effects: from mRNA stability, translation to alternative splicing, across five different cell types. Machine learning model identifies novel m6A‐binding proteins DDX6 and FXR2 and novel m6A reader proteins FUBP3 and L1TD1.
Zhou Huang, Rucong Liu, Zibaguli Wubulikasimu, Wanqing Zhao, Jiaqi Huang, Jiaxuan Wang, Tianyuan Zhang, Rui Fan, Wei Kong, Qinghua Cui, Yang Li, Yuan Zhou   +11 more
wiley   +1 more source

DNMT3A-Mutant Clonal Haematopoiesis Is Associated with Worse Recovery after ST-Elevation Myocardial Infarction Via Increased Inflammation [PDF]

Sarah Mackie, Matthew Sadler, Maroof Hasan, L. Michael Graver, Rupavidhya Mondi Anandhakrishna, Fulye Argunhan, Louis‐François Handfield, H Assefa-Kebede, Laarni Bogaanay, Prodromos Chatzikyriakou, Pilar Casares Aláez, Antonio Cannatà, Mohammad Al-Agil, Amandine Tan, María Ortiz Estévez, Ching‐Pin Chang, Rajasekhar N.V.S. Suragani, Anita K. Gandhi, Anoop Shah, Theresa A. McDonagh, Aleksandar Ívetic, Ghulam Mufti, Giorgio Napolitani, Daniel I. Bromage, Lynn Quek   +24 more
openalex   +1 more source

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

Clonal haematopoiesis of indeterminate potential and mortality in coronary artery disease. [PDF]

Eur Heart J
von Scheidt M, Adkar SS, Krefting J, Hoermann G, Meggendorfer M, Bauer S, Mitchell S, Pugach I, Friess C, Ma A, Hao K, Steigerwald S, Wahle M, Kessler T, Schwab M, Voll F, Mokry M, Sofokleous C, Palm KCA, Bongiovanni D, Fleig J, Oldenbuettel L, Chen Z, Hecker JS, Bassermann F, Maegdefessel L, Graw M, Ruusalepp A, Hilgendorf I, Leuschner F, Sager HB, Heimlich JB, Koenig W, Cremer S, Leistner DM, Abplanalp WT, Dimmeler S, Zeiher AM, van der Laan SW, Pasterkamp G, Braun C, Jaiswal S, Kovacic JC, Kern W, Haferlach C, Mann M, Cassese S, Kastrati A, Haferlach T, Leeper NJ, Björkegren JLM, Schunkert H.   +51 more
europepmc   +1 more source

Systematic tracking of altered haematopoiesis during sporozoite-mediated malaria development reveals multiple response points

, 2016
Maria L. Vainieri, Andrew M. Blagborough, Adam L. MacLean, Myriam Haltalli, Nicola Ruivo, Helen A. Fletcher, Michael P. H. Stumpf, Robert E. Sinden, Cristina Lo Celso   +8 more
openalex   +1 more source